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Fitness costs of Tn1546-type transposons harboring the vanA operon by plasmid type and structural diversity in Enterococcus faecium
BackgroundThis study analyzed the genetic traits and fitness costs of vancomycin-resistant Enterococcus faecium (VREfm) blood isolates carrying Tn 1546...
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Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain
Neurotransmitter receptor densities are relevant for understanding the molecular architecture of brain regions. Quantitative in vitro receptor...
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A novel betapartitivirus isolated from Cordyceps militaris, an edible-medicinal mushroom
In this study, we identified a novel partitivirus, named "Cordyceps militaris partitivirus 1" (CmPV1), in Cordyceps militaris strain RCEF7506. The...
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Classifying Neuronal Cell Types Based on Shared Electrophysiological Information from Humans and Mice
The brain is an intricate system that controls a variety of functions. It consists of a vast number of cells that exhibit diverse characteristics. To...
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Using a new analytic approach for genoty** and phenoty** chromosome 9p deletion syndrome
Using a new analytic method (“unique non-overlap** region” (UNOR) analysis), we characterized the genotypes and phenotypes of a large cohort of...
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Genetic therapies for cardiomyopathy: survey of attitudes of the patient community for the CureHeart project
Cardiomyopathies are a group of inherited heart muscle disorders. Expressivity is variable and while sometimes mild, complications can result in...
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New Variants Identified by Next-Generation Sequencing in Polycystic Kidney Disease Patients
Polycystic kidney disease (PKD) is a common inherited disease characterized by multiple cysts in kidneys and various extra renal manifestations....
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Impact of the COVID-19 pandemic on extended-spectrum β-lactamase producing Escherichia coli in urinary tract and blood stream infections: results from a nationwide surveillance network, Finland, 2018 to 2022
BackgroundBefore the COVID-19 pandemic there has been a constant increase in antimicrobial resistance (AMR) of Escherichia coli , the most common...
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Human cytomegalovirus microRNAs: strategies for immune evasion and viral latency
Viruses use various strategies and mechanisms to deal with cells and proteins of the immune system that form a barrier against infection. One of...
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Cultivation of novel Atribacterota from oil well provides new insight into their diversity, ecology, and evolution in anoxic, carbon-rich environments
BackgroundThe Atribacterota are widely distributed in the subsurface biosphere. Recently, the first Atribacterota isolate was described and the...
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GIS-based spatiotemporal map** of malaria prevalence and exploration of environmental inequalities
Malaria poses a significant threat to global health, with particular severity in Nigeria. Understanding key factors influencing health outcomes is...
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CircFAM114A2 Suppresses Cell Proliferation, Migration, and Invasion of Colorectal Cancer Through Sponging miR-647 to Upregulate DAB2IP Expression
BackgroundIncreasing evidence had proved that some circular RNA (circRNA) exerted critical roles in tumors progression by functioning as “microRNAs...
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Evaluation of the in vitro activity of ampicillin-sulbactam and cefoperazone-sulbactam against A. Baumannii by the broth disk elution test
To evaluate the in vitro activity of ampicillin-sulbactam and cefoperazone-sulbactam against A. baumannii using the broth disk elution testing, a...
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Development and validation of machine learning models to predict MDRO colonization or infection on ICU admission by using electronic health record data
BackgroundMultidrug-resistant organisms (MDRO) pose a significant threat to public health. Intensive Care Units (ICU), characterized by the extensive...
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Secondary attack rate following on-site isolation of patients with suspected COVID-19 in multiple-bed rooms
The implementation of isolation precautions for patients with suspected Coronavirus Disease 2019 (COVID-19) and pending test results is resource...
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A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults
In preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose...
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Genotypic characterization of novel S-DEL variants of porcine epidemic diarrhea virus identified in South Korea
The highly pathogenic genotype 2b (HP-G2b) of porcine epidemic diarrhea virus (PEDV), which caused a pandemic in 2013–2014, evolved in South Korea...
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Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity
BackgroundFecal microbiota transplantation (FMT) is a therapeutic intervention used to treat diseases associated with the gut microbiome. In the...
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Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical priority among fungal...
