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Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model
Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these antibodies can also inhibit de novo immune responses...
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Demonstration of Physicochemical and Functional Similarity of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab
Background and ObjectiveTocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800...
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In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals
Cardiomyocytes are terminal differentiated cells and have limited ability to proliferate or regenerate. Condition like myocardial infarction causes...
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Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events
An essential regulatory hub for retroviral replication events, the 5’ untranslated region (UTR) encodes an ensemble of cis-acting replication...
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CD8+ T cells promote ZIKV clearance and mitigate testicular damage in mice
Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters and causes testicular damage in mouse models. The...
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Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
Urolithin A (UroA), a dietary phytochemical, is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins (ETs). The efficiency...
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Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most...
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Barriers and Enablers Affecting the Uptake of Biosimilar Medicines Viewed Through the Lens of Actor Network Theory: A Systematic Review
Background and ObjectiveBiosimilars represent an opportunity to realise savings against the costs of innovative medicines. Despite efforts made by...
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Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers
Alzheimer’s disease (AD) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in...
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Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland
Several population-level studies have described individual clinical risk factors associated with suboptimal antibody responses following COVID-19...
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The immune factors have complex causal regulation effects on kidney stone disease: a mendelian randomization study
PurposePrevious studies have reported the potential impact of immune cells on kidney stone disease (KSD), but definitive causal relationships have...
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Postmarketing Reports of Incomplete Dosing-Related Complications with Self-Injected PCSK9 Inhibitors: A Descriptive Study and Disproportionality Analysis
BackgroundEvolocumab and alirocumab are self-injected proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors indicated for low-density...
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A randomized phase 1/2a trial of ExPEC10V vaccine in adults with a history of UTI
The safety, reactogenicity, and immunogenicity of 3 doses of ExPEC10V (VAC52416), a vaccine candidate to prevent invasive Escherichia coli disease,...
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Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation,...
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HBXIP induces PARP1 via WTAP-mediated m6A modification and CEBPA-activated transcription in cisplatin resistance to hepatoma
Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA-binding protein that is involved in various biological functions, including DNA damage repair and...
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Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Managing renal fibrosis is challenging owing to the complex cell signaling redundancy in diseased kidneys. Renal fibrosis involves an immune response...
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Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation
Oligodendrocytes (OLs) are differentiated from oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). Demyelination is a common...
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Immune cell phenotypes and mortality in the Framingham Heart Study
BackgroundGlobal life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable...
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Genomic tailoring of autogenous poultry vaccines to reduce Campylobacter from farm to fork
Campylobacter is a leading cause of food-borne gastroenteritis worldwide, linked to the consumption of contaminated poultry meat. Targeting this...
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Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Background and purposeThe immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD)....
