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Analysis of the Effectiveness of CRISPR/Cas9-Editing of the GEX2 Gene by Ribonucleoprotein Complexes in Maize Protoplasts
Abstract —The GEX2 protein is expressed in the maize gamete membranes and is necessary during fertilization at the stage of contact (adhesion) of...
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Bioinformatics Analysis of Non-Synonymous Single Nucleotide Polymorphisms in Human Adk Gene
AbstractAdenosine kinase (ADK) controls adenosine levels. Abnormal concentration of adenosine lead to multiple disorders in humans. In this study,...
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L31 Transposons of Hexacorallia: Distribution, Diversity, and Evolution
Abstract —Transposable elements (TEs) of eukaryotes—retrotransposons and DNA transposons—are nucleotide sequences that can move from locus to locus of...
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Chromosomal Polymorphism of Malaria Mosquitoes of Karelia and Expansion of Northern Boundaries of Species Ranges
AbstractChromosomal variability in peripheral populations of malaria mosquitoes of the Anopheles genus (Diptera, Culicidae) inhabiting the territory...
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The Novel Frameshift Variant of the MYBPC3 Gene Associated with Hypertrophic Cardiomyopathy Significantly Decreases the Level of This Gene Transcript in the Myocardium
Abstract —Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease with a prevalence of 1 : 200–1 : 500 in the general population....
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Paleo-Siberian Substrate in the Gene Pool of Koryaks according to Data on Autosomal SNP Polymorphism and Y-Chromosome Haplogroups
Abstract —The gene pool of the Koryaks was studied in comparison with other Far Eastern and Siberian peoples using a genome-wide panel of autosomal...
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Genetic Identification of Putative Hybrids between Grey Wolf and Golden Jackal
Abstract —We describe the results of genetic analysis of 11 phenotypically deviant individuals of grey wolf Canis lupus Linnaeus, 1758 sensu lato,...
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The Complete Mitochondrial Genome of the Mashen Pig (Sus scrofa)
AbstractMashen pig ( Sus scrofa ) is one of the famous local breeds in China. In this study, we sequenced and reported the complete mitochondrial...
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DNA Methylation in Aortic Aneurysms of Different Localizations
Abstract—Aortic aneurysm (AA) is a life-threatening condition, and aortic rupture that is the complication of AA in the absence of emergency surgery...
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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the...
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Reward prediction error neurons implement an efficient code for reward
We use efficient coding principles borrowed from sensory neuroscience to derive the optimal neural population to encode a reward distribution. We...
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Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology
Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of patients with cancer. To explore the value of whole-genome...
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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma
The presence of basal lineage characteristics signifies hyperaggressive human adenocarcinomas of the breast, bladder and pancreas. However, the...
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Calibrated prediction intervals for polygenic scores across diverse contexts
Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields. We show that PGS performance varies...
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DNA packaging by molecular motors: from bacteriophage to human chromosomes
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always far exceeds the dimensions of the cells that contain it....
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Next-generation data filtering in the genomics era
Genomic data are ubiquitous across disciplines, from agriculture to biodiversity, ecology, evolution and human health. However, these datasets often...
