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Methods and applications of genome-wide profiling of DNA damage and rare mutations
DNA damage is a threat to genome integrity and can be a cause of many human diseases, owing to either changes in the chemical structure of DNA or...
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A proposal for an inclusive working definition of genetic discrimination to promote a more coherent debate
Genetic discrimination is an evolving phenomenon that impacts fundamental human rights such as dignity, justice and equity. Although, in the past,...
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Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also...
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A high-density 1,024-channel probe for brain-wide recordings in non-human primates
Large-scale neural population recordings with single-cell resolution across the primate brain remain challenging. Here we introduce the Neuroscroll...
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Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice
Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental...
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Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown...
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Dynamic of the B Chromosome System in the Population of the Korean Field Mouse Apodemus peninsulae (Mammalia, Rodentia) in the Northern Region of the Pritelets Taiga of the Altai Mountains over a 36-Year Period
Abstract —The process of changes in the number and morphology of B chromosomes in the populations of mice ( Apodemus peninsulae ) in the northern...
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Genomic Microsatellite Mining and Characteristic Analysis of Gobiidae Fish
AbstractMicrosatellites or single sequence repeats (SSRs) are widespread in the genome of eukaryotes and prokaryotes, and are usually used for...
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Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of...
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Assessing the Genetic Diversity of Five Cattle Breeds Using SNP Markers Associated with Health
AbstractCurrently genetic evaluation of animals is an important part of the development of the agricultural complex. The improvement of molecular...
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Effects of Chronic Social Stress on the Expression of Neurotransmitter System–Associated Genes in the Hypothalamus of Male Mice
AbstractChronic social stress caused by repeated negative experiences in agonistic interactions induces depressive-like behavior in male mice. The...
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Anthropology and Genetics of the Tolyonsky Burial Ground No. 93. Udmurtia, Polomskaya Archaeological Culture
AbstractThe problems of the relationship between the cultures of the Volga-Kama region in general and the formation of the Udmurt ethnos involve...
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Identification of miRNA-Target Gene-Transcription Factor Regulatory Network as Functional Motifs Involved in Glomerular Diabetic Nephropathy
AbstractThe gene regulatory approach based on retrieving information from the database provides a detailed characterization of the molecular...
