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Neural representation of human experimenters in the bat hippocampus
Here we conducted wireless electrophysiological recording of hippocampal neurons from Egyptian fruit bats in the presence of human experimenters. In...
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Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1
Direct neuronal reprogramming is a promising approach to regenerate neurons from local glial cells. However, mechanisms of epigenome remodeling and...
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Map** spatially resolved transcriptomes in human and mouse pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and limited treatment options. Efforts to identify effective...
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Indirect neurogenesis in space and time
During central nervous system (CNS) development, neural progenitor cells (NPCs) generate neurons and glia in two different ways. In direct...
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Revealing gene function with statistical inference at single-cell resolution
Single-cell and spatial molecular profiling assays have shown large gains in sensitivity, resolution and throughput. Applying these technologies to...
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Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women,...
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Mitochondrial genetics through the lens of single-cell multi-omics
Mitochondria carry their own genetic information encoding for a subset of protein-coding genes and translational machinery essential for cellular...
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Control and recalibration of path integration in place cells using optic flow
Hippocampal place cells are influenced by both self-motion (idiothetic) signals and external sensory landmarks as an animal navigates its...
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Timescales of learning in prefrontal cortex
The lateral prefrontal cortex (PFC) in humans and other primates is critical for immediate, goal-directed behaviour and working memory, which are...
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Why so slow? Models of parkinsonian bradykinesia
Bradykinesia, or slowness of movement, is a defining feature of Parkinson disease (PD) and a major contributor to the negative effects on quality of...
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A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus
The factors driving or preventing pathological expansion of tandem repeats remain largely unknown. Here, we assessed the FGF14 (GAA)·(TTC) repeat...
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T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major...
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Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes
BackgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating with...
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A sensory–motor theory of the neocortex
Recent neurophysiological and neuroanatomical studies suggest a close interaction between sensory and motor processes across the neocortex. Here, I...
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Identification of transposable element families from pangenome polymorphisms
BackgroundTransposable Elements (TEs) are segments of DNA, typically a few hundred base pairs up to several tens of thousands bases long, that have...
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Sequencing-based analysis of microbiomes
Microbiomes occupy a range of niches and, in addition to having diverse compositions, they have varied functional roles that have an impact on...
