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Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown...
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A novel homozygous variant of the PIGK gene caused by paternal disomy in a patient with neurodevelopmental disorder, cerebellar atrophy, and seizures
Glycosylphosphatidylinositol (GPI)-anchored proteins are located at the cell surface by a covalent attachment between protein and GPI embedded in the...
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R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores
Polygenic risk scores (PRSs) enable early prediction of disease risk. Evaluating PRS performance for binary traits commonly relies on the area under...
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Dynamic of the B Chromosome System in the Population of the Korean Field Mouse Apodemus peninsulae (Mammalia, Rodentia) in the Northern Region of the Pritelets Taiga of the Altai Mountains over a 36-Year Period
Abstract —The process of changes in the number and morphology of B chromosomes in the populations of mice ( Apodemus peninsulae ) in the northern...
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Genomic Microsatellite Mining and Characteristic Analysis of Gobiidae Fish
AbstractMicrosatellites or single sequence repeats (SSRs) are widespread in the genome of eukaryotes and prokaryotes, and are usually used for...
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Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of...
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“Unnatural resources?”: parallels and distinctions between the Newfoundland Genome and traditional resource sectors
Newfoundland and Labrador (NL) has a long history of resource development, exploitation, and frequent mismanagement. Even before joining the Canadian...
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Assessing the Genetic Diversity of Five Cattle Breeds Using SNP Markers Associated with Health
AbstractCurrently genetic evaluation of animals is an important part of the development of the agricultural complex. The improvement of molecular...
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Analysis of the Effectiveness of CRISPR/Cas9-Editing of the GEX2 Gene by Ribonucleoprotein Complexes in Maize Protoplasts
Abstract —The GEX2 protein is expressed in the maize gamete membranes and is necessary during fertilization at the stage of contact (adhesion) of...
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Chromosomal Polymorphism of Malaria Mosquitoes of Karelia and Expansion of Northern Boundaries of Species Ranges
AbstractChromosomal variability in peripheral populations of malaria mosquitoes of the Anopheles genus (Diptera, Culicidae) inhabiting the territory...
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L31 Transposons of Hexacorallia: Distribution, Diversity, and Evolution
Abstract —Transposable elements (TEs) of eukaryotes—retrotransposons and DNA transposons—are nucleotide sequences that can move from locus to locus of...
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Bioinformatics Analysis of Non-Synonymous Single Nucleotide Polymorphisms in Human Adk Gene
AbstractAdenosine kinase (ADK) controls adenosine levels. Abnormal concentration of adenosine lead to multiple disorders in humans. In this study,...
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The Novel Frameshift Variant of the MYBPC3 Gene Associated with Hypertrophic Cardiomyopathy Significantly Decreases the Level of This Gene Transcript in the Myocardium
Abstract —Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease with a prevalence of 1 : 200–1 : 500 in the general population....
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Effects of Chronic Social Stress on the Expression of Neurotransmitter System–Associated Genes in the Hypothalamus of Male Mice
AbstractChronic social stress caused by repeated negative experiences in agonistic interactions induces depressive-like behavior in male mice. The...
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Anthropology and Genetics of the Tolyonsky Burial Ground No. 93. Udmurtia, Polomskaya Archaeological Culture
AbstractThe problems of the relationship between the cultures of the Volga-Kama region in general and the formation of the Udmurt ethnos involve...
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Identification of miRNA-Target Gene-Transcription Factor Regulatory Network as Functional Motifs Involved in Glomerular Diabetic Nephropathy
AbstractThe gene regulatory approach based on retrieving information from the database provides a detailed characterization of the molecular...
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Structure and transcription of integrated HPV DNA in vulvar carcinomas
HPV infections are associated with a fraction of vulvar cancers. Through hybridization capture and DNA sequencing, HPV DNA was detected in five of...
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Paleo-Siberian Substrate in the Gene Pool of Koryaks according to Data on Autosomal SNP Polymorphism and Y-Chromosome Haplogroups
Abstract —The gene pool of the Koryaks was studied in comparison with other Far Eastern and Siberian peoples using a genome-wide panel of autosomal...
