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  1. No Access

    Article

    Combined Strategy of Radioactive 125I Seeds and Salinomycin for Enhanced Glioma Chemo-radiotherapy: Evidences for ROS-Mediated Apoptosis and Signaling Crosstalk

    Radioactive 125I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiothera...

    Chao Liu, Ligang Wang, Hongmei Qiu, Qing Dong, Yong Feng… in Neurochemical Research (2018)

  2. No Access

    Article

    Efficient genome editing in cultured cells and embryos of Debao pig and swamp buffalo using the CRISPR/Cas9 system

    Myostatin (MSTN), a protein encoded by growth differentiation factor 8 (GDF8), is primarily expressed in skeletal muscle and negatively regulates the development and regeneration of muscle. Accordingly, myostatin...

    ** Su, Kuiqing Cui, Shanshan Du… in In Vitro Cellular & Developmental Biology … (2018)

  3. Article

    Open Access

    C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

    Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene...

    Guodong Li, **aoling Hu, Lu Sun, **n Li… in Cellular & Molecular Biology Letters (2018)

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  4. Article

    Open Access

    Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor

    The objective of this study was to identify the protective effect of melatonin (MT) against early brain injury (EBI) following subarachnoid hemorrhage (SAH) and explore the underlying molecular mechanism. Real...

    Song Yang, Wanzhong Tang, Yuchao He, Linbao Wen, Bin Sun… in Cell Death & Disease (2018)

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  5. No Access

    Article

    Bioinformatic Profiling Identifies a Glucose-Related Risk Signature for the Malignancy of Glioma and the Survival of Patients

    The aim of this study is to investigate the glucose metabolic status and its prognostic value in glioma. The Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), and GSE16011 datasets were used ...

    Shihong Zhao, **quan Cai, Jianlong Li, Guiqiu Bao, Di Li… in Molecular Neurobiology (2017)

  6. No Access

    Article

    MicroRNA-144 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by targeting ZFX

    MicroRNA 144 (miR-144), a small non-coding RNA, is frequently dysregulated in human several tumour progression, but its role and the underlying mechanisms in hepatocellular carcinoma (HCC) is poorly investigat...

    Hongbin Bao, **nguo Li, Hengli Li, Hongli **ng, Binghui Xu… in Journal of Biosciences (2017)

  7. No Access

    Article

    Factors affecting efficiency of introducing foreign DNA and RNA into parthenogenetic or in vitro-fertilized porcine eggs by cytoplasmic microinjection

    Cytoplasmic microinjection (CI) of foreign gene into in vivo fertilized zygotes has emerged as a useful tool for transgenic pig production. In the current study, we investigated factors affecting transgenic ef...

    Shuai Liu, **aoQun Liu, HaiYan Huang… in In Vitro Cellular & Developmental Biology … (2016)

  8. Article

    Open Access

    Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

    Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator ...

    Haiyang Zhang, **g**g Duan, Yanjun Qu, Ting Deng, Rui Liu, Le Zhang… in Protein & Cell (2016)

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  9. No Access

    Article

    Validating GWAS-Identified Risk Loci for Alzheimer’s Disease in Han Chinese Populations

    In recent years, genome-wide association studies (GWASs) have identified many novel susceptible genes/loci for Alzheimer’s disease (AD). However, most of these studies were conducted in European and population...

    Hui-Zhen Wang, Rui Bi, Qiu-**ang Hu, Qun **ang, Chen Zhang… in Molecular Neurobiology (2016)

  10. No Access

    Article

    Spatial–Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain

    Recent studies clearly demonstrate major histocompatibility complex (MHC) class I expression in the brain plays an important functional role in neural development and plasticity. A previous study from our lab...

    Jiane Liu, Yuqing Shen, Mingli Li, Dan Lv, Aifeng Zhang… in Neurochemical Research (2015)

  11. No Access

    Article

    Stromal cell-derived factor 1 (SDF-1) accelerated skin wound healing by promoting the migration and proliferation of epidermal stem cells

    Epidermal stem cells could contribute to skin repair through the migration of cells from the neighboring uninjured epidermis, infundibulum, hair follicle, or sebaceous gland. However, little is known about the...

    Rui Guo, Linlin Chai, Liang Chen… in In Vitro Cellular & Developmental Biology … (2015)

  12. No Access

    Article

    MiR-133b Contributes to Arsenic-Induced Apoptosis in U251 Glioma Cells by Targeting the hERG Channel

    Substantial evidence indicates that the human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) is overexpressed in human glioblastoma multiforme (GBM) specimens and plays an essential role in...

    Jian Wang, Yongli Li, Chuanlu Jiang in Journal of Molecular Neuroscience (2015)

  13. No Access

    Article

    Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

    Nocardiopsis alba is frequently isolated from environment and has recently been suggested as a casual symbiotic actinobacterium of diverse invertebrates. Using activity-guided fractionation, we p...

    Yongli Li, Ying-Mi Lai, Yi Lu, Yu-Liang Yang, Shawn Chen in Archives of Microbiology (2014)

  14. No Access

    Article

    Isolation and characterization of mesenchymal stem cells derived from fetal bovine liver

    Bovine liver-derived mesenchymal stem cells (bLMSCs) were isolated from the liver tissue of 4–6 months old fetal calf, and then characterized by immunofluorescence and RT-PCR. We found that primary bLMSCs coul...

    Taofeng Lu, Pengfei Hu, **aohua Su, Changli Li, Yuehui Ma… in Cell and Tissue Banking (2014)

  15. No Access

    Article

    Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

    Inclusions containing TDP43 are linked to pathologies in several neurodegenerative diseases such as ALS and FTD. Pathogenic TDP43 mutations are now found to shorten the protein's half-life in individual neuron...

    Sami J Barmada, Andrea Serio, Arpana Arjun, Bilada Bilican… in Nature Chemical Biology (2014)

  16. No Access

    Article

    Overexpression of CDK5 in Neural Stem Cells Facilitates Maturation of Embryonic Neurocytes Derived from Rats In Vitro

    To further understand the effects of cyclin-dependent kinase 5 (CDK5) on the differentiation of neural stem cells, which were cultured and transfected with CDK5-EGFP recombinant overexpression vector (OV-CDK5 ...

    Hongyu Quan, **yan Wu, Yan** Tian, Yun Wang… in Cell Biochemistry and Biophysics (2014)

  17. No Access

    Article

    Overexpression of Pp14-3-3 from Pyrus pyrifolia fruit increases drought and salt tolerance in transgenic tobacco plant

    Drought and salinity are the major abiotic stresses, which reduce agricultural productivity. In plants, 14-3-3s function as regulators of many target proteins through direct protein-protein interactions and pl...

    Hongli Li, Diqiu Liu, Jian Rao, Yalong Liu, Feng Ge, Chaoyin Chen in Biologia (2014)

  18. No Access

    Article

    IGF1(CA)19 and IGFBP-3-202A/C Gene Polymorphism and Cancer Risk: A Meta-analysis

    Insulin-like growth factor 1 (IGF1)(CA)19 and insulin-like growth factor-binding protein-3 (IGFBP-3)-202A/C gene polymorphisms had been focused by many epidemiological studies recently, which were associated w...

    Hongyu Quan, Hao Tang, Li Fang, Jianjun Bi… in Cell Biochemistry and Biophysics (2014)

  19. No Access

    Article

    Vinyl Chloride Monomer (VCM) Induces High Occurrence of Neural Tube Defects in Embryonic Mouse Brain During Neurulation

    The aim of this study was to explore the direct embryonic teratogenicity of vinyl chloride monomer (VCM), especially the toxic effects on the early development of the nervous system and its underlying mechanis...

    Hongyu Quan, Teng Ma, **anxian Zhao, Baixiong Zhao… in Cellular and Molecular Neurobiology (2014)

  20. Article

    Open Access

    Murine Fig4 is dispensable for muscle development but required for muscle function

    Phosphatidylinositol phosphates (PIPs) are low-abundance phospholipids that participate in a range of cellular processes, including cell migration and membrane traffic. PIP levels and subcellular distribution ...

    Aaron Reifler, Guy M Lenk, **ngli Li, Linda Groom, Susan V Brooks… in Skeletal Muscle (2013)

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