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Open AccessComprehensive investigation of malignant epithelial cell-related genes in clear cell renal cell carcinoma: development of a prognostic signature and exploration of tumor microenvironment interactions
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy with complex heterogeneity within epithelial cells, which plays a crucial role in tumor progression and immune regulation. Yet, the clinical im...
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Open AccessA constrained maximum likelihood approach to develo** well-calibrated models for predicting binary outcomes
The added value of candidate predictors for risk modeling is routinely evaluated by comparing the performance of models with or without including candidate predictors. Such comparison is most meaningful when t...
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Open AccessMycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part by promoting anti...
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Open AccessAdvancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release
Triple-negative breast cancer (TNBC) is a recurrent, heterogeneous, and invasive form of breast cancer. The treatment of TNBC patients with paclitaxel and fluorouracil in a sequential manner has shown promisin...
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Open AccessInfluence and optimization of swirler parameters on elbow wear of deep coal fluidization pipeline transportation system
Elbow wear is a major threat to the multiphase pipeline transportation industry, which has a negative impact on the stable operation of the transportation system. In order to find the wear reduction methods of...
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Open AccessSenescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution
Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role ...
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Open AccessBoundary slip and lubrication mechanisms of organic friction modifiers with effect of surface moisture
Surface moisture or humidity impacting the lubrication property is a ubiquitous phenomenon in tribological systems, which is demonstrated by a combination of molecular dynamics (MD) simulation and experiment f...
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Open AccessFactors associated with trajectories of bone marrow lesions over 4 years: data from the Osteoarthritis Initiative
To identify bone marrow lesion (BML) trajectories over 4 years and their demographic and structural predictors in middle-aged and older adults with or at increased risk of knee osteoarthritis (OA).
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Open AccessIntegrated preparation and manipulation of high-dimensional flying structured photons
The hope for a futuristic global quantum internet that provides robust and high-capacity quantum information transfer lies largely on qudits, the fundamental quantum information carriers prepared in high-dimen...
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Open Access2-year results and myocardial impact of transapical mitral valve repair in patients with primary mitral regurgitation: an echocardiographic study
There is limited data on the 2-year outcomes of transapical transcatheter edge-to-edge repair (TA-TEER) using the ValveClamp in patients with severe primary mitral regurgitation (MR) and its impact on myocardi...
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Open AccessCorrection: A Multiparametric MRI-based Radiomics Model for Stratifying Postoperative Recurrence in Luminal B Breast Cancer
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Open AccessEffectiveness assessment of recent large vision-language models
The advent of large vision-language models (LVLMs) represents a remarkable advance in the quest for artificial general intelligence. However, the models’ effectiveness in both specialized and general tasks war...
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Open AccessNeonatal Cardiac Mesenchymal Stromal Cells Promote Recovery of Infarcted Myocardium through CD44 Mediated FoxP3+ T-Regulatory Cells after Vascular Infusion
Intravenous infusion has been used as the method of cell delivery in many preclinical studies as well as in some early clinical trials. Among its advantages are broad distribution, ability to handle a large-vo...
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Open AccessMembrane protein Bcsdr2 mediates biofilm integrity, hyphal growth and virulence of Botrytis cinerea
Grey mould caused by Botrytis cinerea is a devastating disease responsible for large losses to agricultural production, and B. cinerea is a necrotrophic model fungal plant pathogen. Membrane proteins are importan...
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Open AccessC-H-activated Csp2-Csp3 diastereoselective gridization enables ultraviolet-emitting stereo-molecular nanohydrocarbons with mulitple H···H interactions
Gridization is an emerging molecular integration technology that enables the creation of multifunctional organic semiconductors through precise linkages. While Friedel-Crafts gridization of fluorenols is poten...
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Open AccessBoundary-induced transitions in Möbius quenches of holographic BCFT
Boundary effects play an interesting role in finite-size physical systems. In this work, we study the boundary-induced properties of 1+1-dimensional critical systems driven by inhomogeneous Möbius-like quenche...
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Open AccessTendon extracellular-matrix-derived tissue engineering micro-tissue for Achilles tendon injury regeneration in rats
Achilles tendon is vital in maintaining the stability and function of ankle joint. It is quite difficult to achieve the structural and functional repair of Achilles tendon in tissue engineering.
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Open AccessCorrection: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
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Open AccessDeep learning image reconstruction generates thinner slice iodine maps with improved image quality to increase diagnostic acceptance and lesion conspicuity: a prospective study on abdominal dual-energy CT
To assess the improvement of image quality and diagnostic acceptance of thinner slice iodine maps enabled by deep learning image reconstruction (DLIR) in abdominal dual-energy CT (DECT).
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Open AccessChiral quantum heating and cooling with an optically controlled ion
Quantum heat engines and refrigerators are open quantum systems, whose dynamics can be well understood using a non-Hermitian formalism. A prominent feature of non-Hermiticity is the existence of exceptional po...
