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Open Accessm6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure
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Open AccessStructural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation
The COVID-19 pandemic poses a global threat to public health and economy. The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines. In this st...
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Open AccessDifferential immune responses in pregnant patients recovered from COVID-19
Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 in pregnancy remains to be determined, evidence indicates that the risk factors for severe COVID-19 are simil...
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Open AccessSOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer mainly owing to its proclivity to early metastasis and the lack of effective targeted therapeutic drugs. Hence, understanding the molecular mecha...
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Open AccessIdentification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1
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Open AccessThe arsenal of TP53 mutants therapies: neoantigens and bispecific antibodies
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Open AccessCPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4
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Open AccessMetagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19
COVID-19 remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity. Here, we present the oropharyngeal micro...
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Open AccessAn integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19). In this study,...
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Open AccessGender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster
Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male ...
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Open AccessSTAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17
In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...
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Open AccessKindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...
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Open AccessTargeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common form of acute leukemia in children. Despite this, very little improvement in survival rates has been ...
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Correction: Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessRestoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors
MLL undergoes multiple distinct chromosomal translocations to yield aggressive leukemia with dismal outcomes. Besides their well-established role in leukemogenesis, MLL fusions also possess latent tumor-suppre...
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Open AccessCryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein
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Open AccessSIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle
Sirtuin 7 (SIRT7), an NAD+-dependent deacetylase, plays vital roles in energy sensing, but the underlying mechanisms of action remain less clear. Here, we report that SIRT7 is required for p53-dependent cell-cycl...
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Open AccessNuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin
Enhanced migration is pivotal for the malignant development of glioblastoma (GBM), but the underlying molecular mechanism that modulates the migration of the GBM cells remains obscure. Here we show that nuclea...
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Open AccessInhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia
Venetoclax, an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (AML), is tolerated well in elderly patients with AML and has good overall res...
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Open AccessSimultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia