62 Result(s)
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Medicine & Public Health
Metabolic Diseases
Pharmacology/Toxicology
Yi** **
Conference Paper
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Chapter and Conference Paper
Relapse-Reducing Effects of Acarbose After Weight Reduction in Severely Obese Subjects
The aim of this study (published in 1985) was to investigate whether acarbose has a relapse-preventing effect after body-weight reductions. Twenty-four obese subjects weighing on average 116 kg showed a mean w...
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Chapter and Conference Paper
Discussion
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Chapter and Conference Paper
The Disposition and Pharmacokinetics of Acarbose in Man
Acarbose (Bayg 5421), a competitive and reversible inhibitor of human α-glucosidase activity, attenuates postprandial hyperglycaemia by exerting its enzyme inhibitory activity within the gastrointestinal tract [1...
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Chapter and Conference Paper
Treatment of Streptozotocin-Diabetic Rats with Acarbose: Influence on Metabolism and Heart Function
Streptozotocin (SZ) at 60 mg/kg body weight induces in rats a chronic form of insulin deficiency characterized by hyperglycemia and glucosuria but without any symptoms of ketonemia or ketoacidosis. In parallel...
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Chapter and Conference Paper
Discussion
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Chapter and Conference Paper
Discussion
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Chapter and Conference Paper
The Pharmacological Rationale of Diabetes Mellitus Therapy with Acarbose
Acarbose is a pseudotetrasaccharide (Fig. 1) of microbial origin and reversibly inhibits intestinal alpha-glucosidases [2, 17]. They are located in the luminal brushborder membrane of enterocytes (Fig. 2). The...
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Chapter and Conference Paper
Effects of Acarbose on Experimental Diabetic Nephropathy, Metabolic Control, and Intestinal Glycosidase Activity in Normal and Genetically Diabetic Mice
Acarbose is a complex oligosaccharide and a potent inhibitor of intestinal glycosidase activity. It decreases postprandial hyperglycemia and is most effective when administered with a carbohydrate-containing m...
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Chapter and Conference Paper
Lower Triglyceride Production with Carbohydrate-Rich Diets During Treatment with Acarbose
The possibility that hypertriglyceridaemia, which is closely linked to carbohydrate and insulin metabolism, could be modified by acarbose was tested in seven healthy, normolipidaemic men. The diet provided 65%...
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Chapter and Conference Paper
Acarbose in Insulin-Dependent Diabetes Mellitus: Efficacy and Tolerance
The effect of the α-glucosidase inhibitor acarbose on metabolic control was studied in insulin-dependent diabetics who were accustomed to home monitoring of blood glucose levels and to adapting their insulin d...
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Chapter and Conference Paper
Pharmacodynamics of Acarbose: Clinical Investigations
The pharmacodynamics of the microbial α-glucosidase inhibitor acarbose (Fig. 1) (BAY g 5421; Glucobay) have been investigated in a large number of clinical studies. Several of these have already been reported ...
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Chapter and Conference Paper
Effect of Acarbose on the Hormonal and Metabolic Response to the Simultaneous Ingestion of Sucrose and Ethanol
Previous studies have demonstrated that ethanol potentiates the insulin response to sucrose ingestion and favors the occurrence of reactive hypoglycemia. The present study aimed at investigating the effects of...
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Chapter and Conference Paper
Mode of Action of the α-Glucosidase Inhibitor Acarbose in the Small Bowel: A Perfusion Study in Man
The therapeutic effect of oral α-glucosidase inhibitors in poorly controlled non- insulin-dependent diabetics is due to the retardation of postprandial hydrolysis of starch and sucrose. We performed “slow-mark...
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Chapter and Conference Paper
Effects of Acarbose on Glycemic Control in IDDM under Feedback Control with Artificial Endocrine Pancreas
The aim of the present study was to assess the effects of acarbose on the glycemic control in insulin-dependent diabetes mellitus (IDDM). Five IDDM patients received 100 mg acarbose or placebo with each meal i...
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Chapter and Conference Paper
Acarbose Treatment in Insulin-Dependent Diabetics
In a double-blind, randomized, placebo-controlled, crossover trial 30 insulin-dependent diabetic patients were treated with acarbose, an inhibitor of intestinal α- glucosidases, at the dose of 100 mg T. I. D. ...
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Chapter and Conference Paper
Effect of Acarbose on Colonic Nitrogen Metabolism in Man
The influence of acarbose (BAY g 5421) on colonic nitrogen metabolism was assessed in 12 healthy volunteers. Approximately 25% of urea synthesized in the liver reaches the gut lumen by diffusion and is subsequ...
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Chapter and Conference Paper
Effects of Acarbose on Insulin Sensitivity and Liver Uptake in Patients with Type I Diabetes
Evidence has accumulated that in patients with insulin-dependent (type I) diabetes the addition of acarbose to therapy may reduce insulin requirement and ameliorate metabolic control. The aim of this study is ...
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Chapter and Conference Paper
The Development of a Method for Measuring Starch Absorption and Its Alteration by α-Glucosidase Inhibitors
The kinetics of α-glucosidase-mediated inhibition of sucrose absorption has been studied in man extensively and quantitatively. Although many studies suggest a direct effect also on starch absorption, the quan...
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Chapter and Conference Paper
Acarbose Monotherapy in the Treatment of Non-insulin-Dependent Diabetes Mellitus — a Review
The main aim of treatment of diabetes mellitus is to lower high blood glucose concentrations to the normal level and to improve metabolic abnormalities that are found in diabetic patients. The initial defects ...
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Chapter and Conference Paper
Acarbose in Non-insulin-dependent Diabetes — Long-term Studies in Combination with Oral Agents
Secondary failure of sulphonylurea treatment is often a problem in older diabetics. Maintaining a strict diet may be problematical and switching to insulin — even if it is only one injection — as often happens...
