141 Result(s)

Article

Piperlongumine induces autophagy by targeting p38 signaling

Piperlongumine (PL), a natural product isolated from the plant species Piper longum L., can selectively induce apoptotic cell death in cancer cells by targeting the stress response to reactive oxygen species (...

Y Wang, J-W Wang, X **ao, Y Shan, B Xue, G Jiang, Q He, J Chen… in Cell Death & Disease (2013)

Article

Liver kinase B1 regulates the centrosome via PLK1

Liver kinase B1 (LKB1) is a tumor suppressor mutationally inactivated in Peutz–Jeghers syndrome (PJS) and various sporadic cancers. Although LKB1 encodes a kinase that possesses multiple functions, no individu...

K Werle, J Chen, H-G Xu, R-X Zhao, Q He, C Lu, R Cui, J Liang… in Cell Death & Disease (2014)

Article

LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis

LncRNAs have critical roles in various biological processes ranging from embryonic development to human diseases, including cancer progression, although their detailed mechanistic functions remain illusive. Th...

P Hou, Y Zhao, Z Li, R Yao, M Ma, Y Gao, L Zhao, Y Zhang, B Huang… in Cell Death & Disease (2014)

Article

Multi-locus phylogeny of lethal amanitas: Implications for species diversity and historical biogeography

Lethal amanitas (Amanita section Phalloideae) are a group of wild, fatal mushrooms causing many poisoning cases worldwide. However, the diversity and evolutionary history of these lethal mushrooms remain poorly k...

Qing Cai, Rodham E Tulloss, Li P Tang, Bau Tolgor, ** Zhang… in BMC Evolutionary Biology (2014)

Article

Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo

Cell-based therapies are increasingly recognized as a potential strategy to treat retinal neurodegenerative disease. Their administration, however, is normally indirect and complex, often with an inability to ...

L Guo, B Davis, S Nizari, E M Normando, H Shi, J Galvao, L Turner… in Cell Death & Disease (2014)

Article

Bridger: a new framework for de novo transcriptome assembly using RNA-seq data

We present a new de novo transcriptome assembler, Bridger, which takes advantage of techniques employed in Cufflinks to overcome limitations of the existing de novo assemblers. When tested on dog, human, and mous...

Zheng Chang, Guojun Li, Juntao Liu, Yu Zhang, Cody Ashby, Deli Liu… in Genome Biology (2015)

Article

Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression

The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast ca...

Z B Song, J-S Ni, P Wu, Y L Bao, T Liu, M Li, C Fan, W J Zhang… in Cell Death & Disease (2015)

Article

Heterologous expression and transcript analysis of gibberellin biosynthetic genes of grasses reveals novel functionality in the GA3ox family

The gibberellin (GA) pathway plays a central role in the regulation of plant development, with the 2-oxoglutarate-dependent dioxygenases (2-ODDs: GA20ox, GA3ox, GA2ox) that catalyse the later steps in the bios...

Stephen Pearce, Alison K Huttly, Ian M Prosser, Yi-dan Li… in BMC Plant Biology (2015)

Article

The potential of mesenchymal stem cells in the management of radiation enteropathy

Although radiotherapy is effective in managing abdominal and pelvic malignant tumors, radiation enteropathy is still unavoidable. This disease severely affects the quality of life of cancer patients due to som...

P-Y Chang, Y-Q Qu, J Wang, L-H Dong in Cell Death & Disease (2015)

Article

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein

Primary human fibroblasts undergoing oncogene-induced or replicative senescence are known to form senescence-associated heterochromatin foci (SAHF), which can stabilize the state of senescence. The retinoblast...

L Zhao, Y Zhang, Y Gao, P Geng, Y Lu, X Liu, R Yao, P Hou… in Cell Death & Differentiation (2015)

Article

Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells

Autophagy has been linked to the regulation of both the prevention and progression of cancer. IFN-γ has been shown to induce autophagy in multiple cell lines in vitro. However, whether IFN-γ can induce autophagy ...

X-j **a, Y-y Gao, J Zhang, L Wang, S Zhao, Y-y Che, C-j Ao… in Cell Death Discovery (2016)

Article

Diet-driven interferon-γ enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy

X-j **a, Y-y Che, J Zhang, Y-y Gao, C-j Ao, H-j Yang, J-x Liu… in Cell Death & Disease (2016)