-
Article
Open AccessProspective changes in global DNA methylation and cancer incidence and mortality
Methylation of repetitive elements Alu and LINE-1 in humans is considered a surrogate for global DNA methylation. Previous studies of blood-measured Alu/LINE-1 and cancer risk are inconsistent.
-
Article
Open AccessPre-existing diabetes and lung cancer prognosis
The aims of this study are to investigate the impact of pre-existing diabetes and diabetes treatments on lung cancer prognosis.
-
Article
Open AccessHigh level of interleukin-10 in serum predicts poor prognosis in multiple myeloma
Interleukin-10 (IL-10) is a inhibiting inflammatory cytokine that plays an important role in immune suppressive microenvironment in multiple myeloma (MM). Whether the level of serum IL-10 could predict treatme...
-
Article
Open AccessWild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer
APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear.
-
Article
Open AccessCirculating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer
To verify whether the concentrations and integrity index of circulating cell-free DNA (ccf-DNA) in serum may be clinically useful for the diagnosis and progression monitoring of colorectal cancer (CRC) patients.
-
Article
Open Accessβ-Arrestin1 promotes the progression of chronic myeloid leukaemia by regulating BCR/ABL H4 acetylation
β-Arrestins are scaffold proteins that interact with various cellular signals. Although β-arrestin2 mediates the initiation and progression of myeloid leukaemia, the critical role of β-arrestin1 in the chronic my...
-
Article
Open AccessA network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes
The rapid collection of diverse genome-scale data raises the urgent need to integrate and utilise these resources for biological discovery or biomedical applications. For example, diverse transcriptomic and ge...
-
Article
Open AccessAbrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis
Oesophageal squamous cell carcinoma (SCC) causes the highest number of cancer deaths in some regions of Northern China. Previously, we narrowed down a critical region at 9q33-34, identified to be associated wi...
-
Article
Open AccessActivity of the multikinase inhibitor dasatinib against ovarian cancer cells
Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and f...
-
Article
Open AccessIdentification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer
Proteomic methods have the potential to meet the urgent need for better cancer biomarkers. We have used a range of proteomic analyses of serum and tissue from gastric cancer patients and relevant controls to d...
-
Article
Open AccessDetection of MAGE-A3 in breast cancer patients’ sentinel lymph nodes
The detection of occult metastatic breast cancer cells by RT-PCR is limited by the poor specificity of most tumour mRNA markers. MAGE-A3 is a highly specific tumour mRNA marker that is not expressed in non-can...
-
Article
Open AccessRegulation of differentiation- and proliferation-inducers on Lewis antigens, α-fucosyltransferase and metastatic potential in hepatocarcinoma cells
The expressions of Lewis (Le) antigens, α-1,3/1,4 fucosyltransferases (α-1,3/1,4 FuTs), and metastatic potential after the treatment of 2 differentiation inducers, all-trans retinoic acid (ATRA), 8-bromo-cyclic 3...
-
Article
Open AccessExpression of midkine in the early stage of carcinogenesis in human colorectal cancer
It has been suggested that a heparin-binding growth factor, midkine (MK), plays an important role in carcinogenesis because of its frequent overexpression in various malignant tumours. To clarify whether or no...
-
Article
Expression of transforming growth factor α, amphiregulin and cripto-1 in human breast carcinomas
The expression of three epidermal growth factor (EGF)-related peptides, transforming growth factor alpha (TGF-alpha), amphiregulin (AR) and cripto-1 (CR-1), was examined by immunocytochemistry (ICC) in 68 prim...