48 Result(s)
within
English
Science, multidisciplinary
**-peng Pei
Article
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Article
Open AccessEngineering antiviral immune-like systems for autonomous virus detection and inhibition in mice
The ongoing COVID-19 pandemic has demonstrated that viral diseases represent an enormous public health and economic threat to mankind and that individuals with compromised immune systems are at greater risk of...
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Article
Open AccessDiverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S
Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation1–4. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation on lysine 36 (H3K36me3) and deacety...
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Article
Open AccessSite-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-bas...
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Article
Open AccessPrussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments
Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in can...
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Article
Open AccessIRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice
Cardiac fibrosis is a common feature of chronic heart failure. Iroquois homeobox (IRX) family of transcription factors plays important roles in heart development; however, the role of IRX2 in cardiac fibrosis ...
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Article
Subsecond periodic radio oscillations in a microquasar
Powerful relativistic jets are one of the ubiquitous features of accreting black holes in all scales1–3. GRS 1915 + 105 is a well-known fast-spinning black-hole X-ray binary4 with a relativistic jet, termed a ‘mi...
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Article
Open AccessTopological electronic structure and spin texture of quasi-one-dimensional higher-order topological insulator Bi4Br4
The notion of topological insulators (TIs), characterized by an insulating bulk and conducting topological surface states, can be extended to higher-order topological insulators (HOTIs) hosting gapless modes l...
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Article
Open AccessAn atlas of epithelial cell states and plasticity in lung adenocarcinoma
Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1. Here we studied 246,102 single epithelial cells from 16 early-stage LU...
