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Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
Although the increased prevalence of Parkinson’s disease (PD) with aging suggests that aging processes predispose dopamine neurons to degeneration, the mechanism involved remains unknown. Dopamine neurons cont...
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Melatonin protects mice with intermittent hypoxia from oxidative stress-induced pancreatic injury
One of the most important mechanisms linking obstructive sleep apnea (OSA) to insulin resistance and type 2 diabetes involves oxidative stress. We examined whether oxidative stress-induced pancreatic injury co...
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Structures and connections of enkephalin- and γ-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study
GABA and enkephalin (ENK) are principle inhibitory transmitters in the rostral portion of the nucleus tractus solitarius (rNTS) for regulating the gustatory information. Although the existence of GABA- and ENK...
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Article
Spinocerebellar ataxia type 11 in the Chinese Han population
The spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative diseases. Researchers have recently found that SCA type 11 (SCA11) is associated with mutations in the
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Poster abstracts
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Article
Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture
Formation of neurofibrillary tangle from hyperphosphorylated tau is one of the hallmark lesions seen in Alzheimer’s disease (AD) brain, and neuronal deregulation of glycogen synthase kinase-3 (GSK-3) activity ...