12,474 Result(s)
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Zhou **u
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessProteomics shows that brain metastases of lung adenocarcinoma overexpress ribosomal proteins in response to gamma knife radiosurgery
Gamma knife radiosurgery (GKRS) is recommended as the first-line treatment for brain metastases of lung adenocarcinoma (LUAD) in many guidelines, but its specific mechanism is unclear. We aimed to study the ch...
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Open AccessDasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory
5-Fluorouracil (5-Fu) is a basic drug that is used to treat colorectal cancer. Patients who receive 5-Fu chemotherapy often experience side effects that affect the digestive system, such as intestinal injury a...
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Open AccessA rhinopithecus swarm optimization algorithm for complex optimization problem
This paper introduces a novel meta-heuristic algorithm named Rhinopithecus Swarm Optimization (RSO) to address optimization problems, particularly those involving high dimensions. The proposed algorithm is ins...
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Open AccessHumid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice
Climate and environmental changes threaten human mental health, but the impacts of specific environmental conditions on neuropsychiatric disorders remain largely unclear. Here, we show the impact of a humid he...
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Open AccessEngineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces
Base editing (BE) faces protospacer adjacent motif (PAM) constraints and off-target effects in both eukaryotes and prokaryotes. For Streptomyces, renowned as one of the most prolific bacterial producers of antibi...
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Open AccessHydraulic system fault diagnosis decoupling method based on 2D time-series modeling and self-attention fusion
Hydraulic systems play a pivotal and extensive role in mechanics and energy. However, the performance of intelligent fault diagnosis models for multiple components is often hindered by the complexity, variabil...
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Open AccessDataset of soil hydraulic parameters in the Yellow River Basin based on in situ deep sampling
Soil hydraulic parameters are vital for precisely characterizing soil hydrological processes, which are critical indicators for regulating climate change effects on terrestrial ecosystems and governing feedbac...
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Open AccessMulti-omics and single cell characterization of cancer immunosenescence landscape
Cellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored the relationship between cancer senescence signature and telomere le...
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Open AccessTelomere-to-telomere genome assembly of the goose Anser cygnoides
Our study presents the assembly of a high-quality Taihu goose genome at the Telomere-to-Telomere (T2T) level. By employing advanced sequencing technologies, including Pacific Biosciences HiFi reads, Oxford Nan...
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Open AccessChromosome-level genome assembly of an oligophagous leaf beetle Ophraella communa (Coleoptera: Chrysomelidae)
The leaf beetle Ophraella communa LeSage (Coleoptera: Chrysomelidae) is an effective biological control agent of the common ragweed. Here, we assembled a chromosome-level genome of the O. communa by combining Ill...
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Open AccessChildren and adults produce distinct technology- and human-directed speech
This study compares how English-speaking adults and children from the United States adapt their speech when talking to a real person and a smart speaker (Amazon Alexa) in a psycholinguistic experiment. Overall...
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Open AccessMethanogenesis in the presence of oxygenic photosynthetic bacteria may contribute to global methane cycle
Accumulating evidences are challenging the paradigm that methane in surface water primarily stems from the anaerobic transformation of organic matters. Yet, the contribution of oxygenic photosynthetic bacteria...
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Open AccessAggregation promotes charge separation in fullerene-indacenodithiophene dyad
Fast photoinduced charge separation (CS) and long-lived charge-separated state (CSS) in small-molecules facilitate light-energy conversion, while simultaneous attainment of both remains challenging. Here we ac...
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Open AccessPre-trained multimodal large language model enhances dermatological diagnosis using SkinGPT-4
Large language models (LLMs) are seen to have tremendous potential in advancing medical diagnosis recently, particularly in dermatological diagnosis, which is a very important task as skin and subcutaneous dis...
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Open AccessExploring the ecological security evaluation of water resources in the Yangtze River Basin under the background of ecological sustainable development
The Yangtze River (hereafter referred to as the YZR), the largest river in China, is of paramount importance for ensuring water resource security. The Yangtze River Basin (hereafter referred to as the YRB) is ...
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Open AccessSurface photogalvanic effect in Ag2Te
The bulk photovoltaic effect (BPVE) in non-centrosymmetric materials has attracted significant attention in recent years due to its potential to surpass the Shockley-Queisser limit. Although these materials ar...
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Open AccessEffect of temperature and pre-stretch on the dynamic performance of dielectric elastomer minimum energy structure
Dielectric Elastomer Minimum Energy Structures (DEMES) have the ability of actively adjusting their shape to accommodate complex scenarios, understanding the actuation mechanism of DEMES is essential for their...
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Open AccessA novel technique for the single-port laparoscopic percutaneous extraperitoneal closure (SLPEC) of paediatric isolated giant inguinal hernias using double-modified hernia needles
The objective was to explore the efficacy of single-port laparoscopic percutaneous extraperitoneal closure using double-modified hernia needles with hydrodissection (SLPEC group) and two-port laparoscopic perc...
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Open AccessUnraveling the energy storage mechanism in graphene-based nonaqueous electrochemical capacitors by gap-enhanced Raman spectroscopy
Graphene has been extensively utilized as an electrode material for nonaqueous electrochemical capacitors. However, a comprehensive understanding of the charging mechanism and ion arrangement at the graphene/e...
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Open AccessEnantiopure trigonal bipyramidal coordination cages templated by in situ self-organized D2h-symmetric anions
The control of a molecule’s geometry, chirality, and physical properties has long been a challenging pursuit. Our study introduces a dependable method for assembling D3-symmetric trigonal bipyramidal coordination...
