858 Result(s)
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Open AccessGuiding antibiotics towards their target using bacteriophage proteins
Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster and cheaper way to get them might be by repurposing existing antibiotics. Nanodelivery system...
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Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Open AccessEngineering ZrO2–Ru interface to boost Fischer-Tropsch synthesis to olefins
Understanding the structures and reaction mechanisms of interfacial active sites in the Fisher-Tropsch synthesis reaction is highly desirable but challenging. Herein, we show that the ZrO2-Ru interface could be e...
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Open AccessREEP3 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in pancreatic cancer
Receptor Expression-Enhancing Protein 3 (REEP3) serves as a pivotal enzyme crucial for endoplasmic reticulum (ER) clearance during mitosis and is implicated in the advancement of diverse malignancies. Nonethel...
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Open AccessHydrogen peroxide is required for light-induced stomatal opening across different plant species
Stomatal movement is vital for plants to exchange gases and adaption to terrestrial habitats, which is regulated by environmental and phytohormonal signals. Here, we demonstrate that hydrogen peroxide (H2O2) is r...
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Open AccessProgrammable melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies
Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to enhance antitumor effects and offers emerging opportunities for treating invasive tumor indications such as melanoma. H...
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Open AccessLigand-mediate exciton allocation enables efficient cluster-based white light-emitting diodes via single and heavy do**
Despite potential in high-resolution and low-cost displays and lighting, multi-do** structures and low concentrations (<1%) limit repeatability and stability of single-emissive-layer white light-emitting dev...
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Open AccessCosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as t...
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Open AccessGenerative learning facilitated discovery of high-entropy ceramic dielectrics for capacitive energy storage
Dielectric capacitors offer great potential for advanced electronics due to their high power densities, but their energy density still needs to be further improved. High-entropy strategy has emerged as an effe...
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Open AccessAn empirical analysis of the coupling and coordinated development of new urbanization and ecological welfare performance in China’s Chengdu–Chongqing economic circle
New urbanization (NU) and ecological welfare performance (EWP) play pivotal roles in achieving sustainable urban development, with both emphasizing social equity and environmental management. Exploring the coo...
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Open AccessRule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates
Antimicrobial resistance remains a significant global threat, driving up mortality rates worldwide. Ribosomally synthesized and post-translationally modified peptides have emerged as a promising source of nove...
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Open AccessThe thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity
Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown promising results in preclinical studies but have d...
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Open AccessChromosome-level genome assembly and annotation of the cold-water species Ophiura sarsii
The cold-water species Ophiura sarsii, a brittle star, is a key echinoderm in the Arctic continental shelf region, highly sensitive to climate change. However, the absence of a high-quality genome has hindered a ...
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Open AccessAn accurate semantic segmentation model for bean seedlings and weeds identification based on improved ERFnet
In agricultural production activities, the growth of crops always accompanies the competition of weeds for nutrients and sunlight. In order to mitigate the adverse effects of weeds on yield, we apply semantic ...
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Open AccessMicrotopography effects on pedogenesis in the mudstone-derived soils of the hilly mountainous regions
Topography is a critical factor that determines the characteristics of regional soil formation. Small-scale topographic changes are referred to microtopographies. In hilly mountainous regions, the redistributi...
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Open AccessNylons with Highly-Bright and Ultralong Organic Room-Temperature Phosphorescence
Endowing the widely-used synthetic polymer nylon with high-performance organic room-temperature phosphorescence would produce advanced materials with a great potential for applications in daily life and indust...
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Open AccessUncovering the characteristics of the gut microbiota in patients with ischemic stroke and hemorrhagic stroke
This study aimed to explore the gut microbiota characteristics of ischemic and hemorrhagic stroke patients. A case–control study was conducted, and high-throughput sequencing of the V4–V5 region of 16S rRNA wa...
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Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Open AccessHigh-performance flexible p-type Ce-filled Fe3CoSb12 skutterudite thin film for medium-to-high-temperature applications
P-type Fe3CoSb12-based skutterudite thin films are successfully fabricated, exhibiting high thermoelectric performance, stability, and flexibility at medium-to-high temperatures, based on preparing custom target ...
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Open AccessPhotoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain
Cross-modal analysis of the same whole brain is an ideal strategy to uncover brain function and dysfunction. However, it remains challenging due to the slow speed and destructiveness of traditional whole-brain...
