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Article
Allogeneic mRNA-based electrotransfection of autologous dendritic cells and specific antitumor effects against osteosarcoma in rats
Vaccination with dendritic cells (DCs) transfected with tumor-derived mRNA antigen has emerged as a promising strategy for generating protective immunity in mammals. However, the integration of allogeneic oste...
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Article
Cancer Microenvironment and Cancer Vaccine
The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal an...
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Article
Open AccessEvaluation of inter-fraction and intra-fraction errors during volumetric modulated arc therapy in nasopharyngeal carcinoma patients
This prospective study was conducted to evaluate inter- and intra-fraction errors in nasopharyngeal carcinoma (NPC) patients undergoing volumetric modulated arc therapy (VMAT) using cone-beam computed tomograp...
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Article
Open AccessUsing the lymph nodal ratio to predict the risk of locoregional recurrence in lymph node-positive breast cancer patients treated with mastectomy without radiation therapy
To evaluate the prognostic value of axillary lymph node ratio (LNR) as compared to the number of involved nodes (pN stage) in patients with axillary lymph node-positive breast cancer treated with mastectomy wi...
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Article
The flavonoid casticin enhances TRAIL-induced apoptosis of colon cancer cells through endoplasmic reticulum stress-mediated up-regulation of DR5
The aim of this study was to explore the mechanisms by which the flavonoid casticin enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in colon cancer cells.
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Article
Open AccessInduction of autophagy by cystatin C: a potential mechanism for prevention of cerebral vasospasm after experimental subarachnoid hemorrhage
Studies have demonstrated that autophagy pathways are activated in the brain after experimental subarachnoid hemorrhage (SAH) and this may play a protective role in early brain injury. However, the contributio...
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Article
Open AccessRadiation-induced temporal lobe injury after intensity modulated radiotherapy in nasopharyngeal carcinoma patients: a dose-volume-outcome analysis
To identify the radiation volume effect and significant dosimetric parameters for temporal lobe injury (TLI) and determine the radiation dose tolerance of the temporal lobe (TL) in nasopharyngeal carcinoma (NP...
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Article
Open AccessLivin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy
This study was aimed to investigate the expression significance of Livin in relation to radiotherapy (RT), clinicopathological and biological factors of rectal cancer patients.
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Article
Macro-Aspartate Aminotransferase: Two-Year Follow-Up of Three Patients in China
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Article
Suppressive Effects of Subchronic Aluminum Overload on the Splenic Immune Function May Be Related to Oxidative Stress in Mice
Aluminum (Al) is widely used in daily life and was recently recognized as a possible source of human intoxication because of its ability to accumulate in organs. The objective of the present study was to inves...
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Article
miR-145 functions as tumor suppressor and targets two oncogenes, ANGPT2 and NEDD9, in renal cell carcinoma
Abnormal expression of miRNAs is closely related to a variety of human cancers. The purpose of this study is to identify new tumor suppressor miRNA and elucidate its physiological function and mechanism in ren...
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Article
Mannan-modified adenovirus encoding VEGFR-2 as a vaccine to induce anti-tumor immunity
Dendritic cell (DC) vaccines are a promising immunotherapeutic approach for treatment and prevention of cancer. While this methodology is widely accepted, it also has some limitations. Antigen-presenting cells...
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Article
Beclin-1-mediated autophagy protects spinal cord neurons against mechanical injury-induced apoptosis
Apoptosis has been widely reported to be involved in the pathogenesis associated with spinal cord injury (SCI). Recently, autophagy has also been implicated in various neuronal damage models. However, the role...
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Article
A novel mitovirus from Buergenerula spartinae infecting the invasive species Spartina alterniflora
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Article
A novel mitovirus from Buergenerula spartinae infecting the invasive species Spartina alterniflora
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Article
Open AccessGamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
Gamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, the underlying mechanism of CS-6 involved in a...
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Article
Open AccessMeta-analysis shows that circulating tumor cells including circulating microRNAs are useful to predict the survival of patients with gastric cancer
Circulating tumor cells (CTCs) are metastatic cells disseminated into the bloodstreams. They have been proposed to monitor disease progression for decades. However, the prognostic value of CTCs in gastric canc...
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Article
Open AccessDosimetric analysis of the brachial plexus among patients with breast cancer treated with post-mastectomy radiotherapy to the ipsilateral supraclavicular area: report of 3 cases of radiation-induced brachial plexus neuropathy
The purpose of this study was to evaluate the brachial plexus (BP) dose of postmastectomy radiotherapy (PMRT) to the ipsilateral supraclavicular (ISCL) area, and report the characteristics of radiation-induced...
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Article
Open AccessNumber of negative lymph nodes can predict survival of breast cancer patients with four or more positive lymph nodes after postmastectomy radiotherapy
This study was conducted to assess the prognostic value of the number of negative lymph nodes (NLNs) in breast cancer patients with four or more positive lymph nodes after postmastectomy radiotherapy (PMRT).
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Immunopathology of Hepatobiliary Tumors and Immunotherapy of Liver Cancers
Hepatobiliary tumors are a diverse group of tumors that arise from the hepatobiliary tract including the liver, gallbladder, and bile tract. Hepatocellular cancer is the most common type of liver cancer and is...
