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Article
Azocalixarenes: a scaffold of universal excipients with high efficiency
Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, incl...
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Article
The catalytic triad of rice NARROW LEAF1 involves H234
NARROW LEAF1 (NAL1) exerts a multifaceted influence on leaf morphology and crop yield. Recent crystal study proposed that histidine 233 (H233) is part of the catalytic triad. Here we report that unlike suggested ...
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Article
Evaluation of the Efficacy of Stem Cells Therapy in the Periodontal Regeneration: A Meta-Analysis and Mendelian Randomization Study
Stem cell therapy for periodontal defects has shown good promise in preclinical studies. The purpose of this study was to evaluate the impact of stem cell support on the regeneration of both soft and hard tiss...
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Article
A modified drag coefficient model for calculating the terminal settling velocity and horizontal diffusion distance of irregular plume particles in deep-sea mining
Deep-sea mining inevitably produces plumes, which will pose a serious threat to the marine environment with the continuous movement and diffusion of plumes along with ocean currents. The terminal settling velo...
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Article
Open AccessInvestigation of the correlation between platelet antibodies and peripheral blood cytopenia in patients with hepatocellular carcinoma
The primary triggers that stimulate the body to generate platelet antibodies via immune mechanisms encompass events such as pregnancy, transplantation, and blood transfusion. Interestingly, our findings reveal...
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Article
Open AccessCardiovascular mortality risk in patients with ovarian cancer: a population-based study
Ovarian cancer (OC) can occur at different ages and is affected by a variety of factors. In order to evaluate the risk of cardiovascular mortality in patients with ovarian cancer, we included influencing facto...
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Article
Open AccessYoung osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate osteogenesis or excessive adipogenesis as they age due to changes in the bone microenvironment, ultimately resulting in decreased bone density ...
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Article
Determination and Correlation of Phase Equilibria of Quaternary System KCl–KH2PO4–CO(NH2)2–H2O and Its Ternary Subsystems at 323.15 and 333.15 K
Solid-liquid phase equilibrium of the quaternary system KCl–KH2PO4–CO(NH2)2–H2O and its subsystems KH2PO4–CO(NH2)2–H2O and KCl–KH2PO4–H2O at 323.15 and 333.15 K were investigated through the isothermal solution e...
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Article
Open AccessOral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes
The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...
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Article
Pruritic Erythema in a Child with Undifferentiated Connective Tissue Disease
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Article
Geriatric nutrition risk index: a more powerful index identifying muscle mass loss in patients with rheumatoid arthritis
To explore the association of geriatric nutrition risk index (GNRI), a traditional albumin-body weight calculation, with myopenia in patients with rheumatoid arthritis (RA) and compare its ability to identify ...
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Article
The field-scale stabilization remediation and assessment of potential toxic elements based on the multi-source information from a Chinese Pb/Zn smelter contaminated site
Potential toxic elements (PTEs) generally co-existing in soils make a great challenge to the sustainable development and utilization of smelter contaminated sites. This study delved into the pollution characte...
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Article
Characteristic, resource approaches and safety utilization assessment of non-ferrous metal smelting slags: A literature review
As an industrial byproduct of smelter operations, smelting slag has brought certain environmental issues including without taking safety precautions or using appropriate management. Through a thorough analysis...
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Article
The longevity evaluation of multi-metal stabilization by MgO in Pb/Zn smelter–contaminated soils
The re-mobilization risks of potentially toxic elements (PTEs) during stabilization deserve to be considered. In this study, artificial simulation evaluation methods based on the environmental stress of freeze...
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Article
Open AccessEvaluating the Demand for Nucleic Acid Testing in Different Scenarios of COVID-19 Transmission: A Simulation Study
The 2019 novel coronavirus (COVID-19) has been recognized as the most severe human infectious disease pandemic in the past century. To enhance our ability to control potential infectious diseases in the future...
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Article
Open AccessRevolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives
The deployment of imaging examinations has evolved into a robust approach for the diagnosis of lymph node metastasis (LNM). The advancement of technology, coupled with the introduction of innovative imaging dr...
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Article
Open AccessCD4+CD25+ regulatory T cells ex vivo generated from autologous naïve CD4+ T cells suppress EAE progression
CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining immune homeostasis in multiple sclerosis (MS). Hence, we aimed to explore the therapeutic efficacy and safety of adoptive cell therapy (A...
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Article
Ultra-high-rate Bi anode encapsulated in 3D lignin-derived carbon framework for sodium-ion hybrid capacitors
Bismuth (Bi), as an alloy-based anode material, has attracted much attention in the development of sodium-ion hybrid capacitors (SIHCs) due to its high theoretical capacity. However, the volume expansion of th...
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Article
Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial
To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy (DPN).
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Article
Open AccessAn integrated data analysis reveals distribution, hosts, and pathogen diversity of Haemaphysalis concinna
Haemaphysalis concinna, carrying multiple pathogens, has attracted increasing attention because of its expanded geographical range and significant role in disease transmission. This study aimed to identify the po...
