38 Result(s)
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Open AccessInvolvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats
The present study was performed to explore the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central nucleus of amygdala (CeA) in normal rats and rats with neuropathy, and th...
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Open AccessStructure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site
We have synthesized a series of new β-lactam-azide derivatives as orally active anti-tumor agents by targeting tubulin colchicine binding site and examined their structure activity relationship (SAR). Among them,...
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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.
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Open AccessCallistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis
A new acylphloroglucinol with a novel architecture including an unprecedented dearomatic dibenzofuran core, named callistemenonone A (1), was isolated from the leaves of Callistemon viminalis (Myrtaceae). The str...
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Open AccessDeep brain stimulation for myoclonus-dystonia syndrome with double mutations in DYT1 and DYT11
Myoclonus-dystonia syndrome (MDS) is a rare autosomal dominant inherited disorder characterized by the presentation of both myoclonic jerks and dystonia. Evidence is emerging that deep brain stimulation (DBS) ...
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Open AccessDevelopment and evaluation of near-isogenic lines for brown planthopper resistance in rice cv. 9311
Brown planthopper (BPH) is the most destructive pest of rice in Asia. To date 29 BPH resistance genes have been identified, but only a few genes are being used in breeding due to inefficient markers for marker...
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Open AccessSleep duration, daytime nap**, markers of obstructive sleep apnea and stroke in a population of southern China
Sleep habits are associated with stroke in western populations, but this relation has been rarely investigated in China. Moreover, the differences among stroke subtypes remain unclear. This study aimed to expl...
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Open AccessIdentification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis
KIF11 gene mutations cause a rare autosomal dominant inheritable disease called microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR). Recently, such mutations were also found ...
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Open AccessSpatial and seasonal variations of isoprene secondary organic aerosol in China: Significant impact of biomass burning during winter
Isoprene is a substantial contributor to global secondary organic aerosol (SOA). The formation of isoprene SOA (SOAI) is highly influenced by anthropogenic emissions. Currently, there is rare information regardin...
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Open AccessFlame treatment of graphene oxides: cost-effective production of nanoporous graphene electrode for Lithium-ion batteries
A facile production of highly porous graphene foam by using flame treatment of graphene oxide (GO) is proposed. Highly porous architectures with randomly distributed micro-crack and micro-slit were produced du...
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Erratum: Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress
Epigenetic regulations including DNA methylation and demethylation play critical roles in neural development. However, whether DNA methylation and demethylation may play a role in neuronal cell death remains l...
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Open AccessTet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress
Epigenetic regulations including DNA methylation and demethylation play critical roles in neural development. However, whether DNA methylation and demethylation may play a role in neuronal cell death remains l...
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Open AccessProcessing and characterisation of a novel electropolymerized silk fibroin hydrogel membrane
Silk fibroin can be made into various forms of biocompatible medical materials, including hydrogel due to its excellent properties. Here, we report a novel method for the preparation of electropolymerized silk...
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Open AccessBulk induced phase transition in driven diffusive systems
This paper studies a weakly and asymmetrically coupled three-lane driven diffusive system. A non-monotonically changing density profile in the middle lane has been observed. When the extreme value of the densi...
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Open AccessA novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material
A novel sodium N-fatty acyl amino acid (SFAAA) surfactant was synthesized using pupa oil and pupa protein hydrolysates (PPH) from a waste product of the silk industry. The aliphatic acids from pupa oil were mo...
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Open AccessChromatin remodelling complex dosage modulates transcription factor function in heart development
Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not understood. Interactions between transcription factors and ...
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Primary afferent tachykinins are required to experience moderate to intense pain
The excitatory neurotransmitter glutamate coexists with the peptide known as substance P in primary afferents that respond to painful stimulation1. Because blockers of glutamate receptors reliably reduce pain beh...
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Origin of the magnetic spiral arms in the galaxy NGC6946
THE recent discovery1 of coherent, large-scale magnetic spiral arms located between the optical spiral arms of the nearby galaxy NGC6946 is difficult to reconcile with current galactic dynamo theory2. The formati...
