56 Result(s)
within
Hepatology
Yoshiyuki Ueno
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Article
Open AccessTransition in the etiology of liver cirrhosis in Japan: a nationwide survey
To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH).
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Article
Steeper steps and pledge for inevitable responsibilities
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Article
A novel pathogenic variant of ATP-binding cassette subfamily B member 4 causing gallstones in a young adult
The low phospholipid-associated cholelithiasis (LPAC) syndrome was reported in European adults with cholelithiasis and a mutation of the ATP-binding cassette subfamily B member 4 (ABCB4). The ABCB4 encodes multid...
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Article
Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium
One-third of the global hepatitis C virus (HCV) burden is found in Asia. Real-world data from diverse East Asian cohorts remain limited. This study addressed the real-world status of direct-acting antiviral (D...
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Article
Esophageal intramural pseudodiverticulosis complicated with severe stricture requiring surgical resection
Esophageal intramural pseudodiverticulosis (EIPD) is an uncommon benign disorder leading to esophageal strictures. The etiology remains unknown; however, anti-fungal treatments or endoscopic balloon dilation c...
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Article
New treatment-induced adverse effects we need to learn as modern hepatologists
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Article
Safety and efficacy of glecaprevir and pibrentasvir in Japanese hemodialysis patients with genotype 2 hepatitis C virus infection
Until recently, interferon-free anti-hepatitis C virus (HCV) therapy for genotype 2 (GT2) HCV-infected hemodialysis patients was an unfulfilled medical need. Recent clinical trials of glecaprevir and pibrentas...
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Chapter
Prevention of Hepatocarcinogenesis in Liver Cirrhosis
Hepatocellular carcinoma (HCC) is still the second leading cause of cancer-related deaths in men worldwide. Most cases of HCC arise in the cirrhotic liver by various causes of hepatitis. In this chapter, we de...
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Article
New generation cancer therapy: right direction for sure with some uncertainty
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Article
Safety and efficacy of elbasvir and grazoprevir in Japanese hemodialysis patients with genotype 1b hepatitis C virus infection
The prevalence of hepatitis C virus (HCV) infection in hemodialysis patients is high and results in a poor prognosis. Thus, safer and more effective treatment regimens are required. In this prospective multice...
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Article
Open AccessEfficacy and safety of sofosbuvir–velpatasvir with or without ribavirin in HCV-infected Japanese patients with decompensated cirrhosis: an open-label phase 3 trial
In Japan, hepatitis C virus (HCV)-infected patients with decompensated cirrhosis currently have no treatment options. In this Phase 3 study, we evaluated sofosbuvir–velpatasvir with or without ribavirin for 12...
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Article
Open AccessSofosbuvir–velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 hepatitis C who failed direct-acting antivirals
In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir–velpa...
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Article
Daclatasvir and asunaprevir in hemodialysis patients with hepatitis C virus infection: a nationwide retrospective study in Japan
Hepatitis C virus (HCV) infection is common in hemodialysis patients and worsens their prognosis, while antiviral therapy options are limited. Recently, clinical trial and real-world, small-scale studies have ...
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Article
Diagnosis and treatment of eosinophilic esophagitis in clinical practice
Eosinophilic esophagitis (EoE) is a chronic and abnormal Th2 type immunological response characterized by intense eosinophilic inflammation localized within the esophagus. This leads to esophageal dysfunction ...
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Article
The prognosis of hepatitis B inactive carriers in Japan: a multicenter prospective study
Hepatitis B e antigen (HBeAg)-negative inactive carriers, the majority of hepatitis B virus (HBV) carriers, are considered to have a good prognosis. The definition of the inactive HBV carrier state has been ba...
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Article
Evidence-based clinical practice guidelines for liver cirrhosis 2015
The Japanese Society of Gastroenterology revised the evidence-based clinical practice guidelines for liver cirrhosis in 2015. Eighty-three clinical questions were selected, and a literature search was performe...
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Article
Erratum to: A thymine–adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus
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Article
A thymine–adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus
Genome-wide association studies have revealed several single-nucleotide polymorphisms around interleukin 28B (IL28B) that are strongly associated with hepatitis C virus (HCV) clearance. However, their predicti...
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Article
Possible autoimmune hepatitis induced after chronic active Epstein−Barr virus infection
Chronic active Epstein−Barr virus infection (CAEBV) can be manifested in a variety of systemic conditions, including interstitial pneumonia, malignant lymphoma, and coronary aneurysm. Sometimes it may be assoc...
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Chapter
Animal Models for Primary Biliary Cirrhosis
Recent PBC mouse models underwent extensive gene modifications and immunomodulations to elucidate functions of their products and signaling pathway in autoimmune cholangitis. Expanded hepatic memory CD8+ T cells ...
