315 Result(s)

Article

Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

Mitochondria have been identified to be involved in oxidative phosphorylation, lipid metabolism, cell death, and cell proliferation. Previous studies have demonstrated that mitoguardin (Miga), a mitochondrial ...

Ming-Qi Yan, Bing-Hong Zhu, **ao-Hong Liu, Yu-Meng Yang… in Cell Death & Disease (2023)

Article

Single-cell and spatial architecture of primary liver cancer

Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity and heterogeneity among PLCs remains challenging. Here, usi...

Pei-Yun Zhou, Cheng Zhou, Wei Gan, Zheng Tang, Bao-Ye Sun… in Communications Biology (2023)

Article

LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX

LASS2 functions as a tumor suppressor in hepatocellular carcinoma (HCC), the most common type of primary liver cancer, but the underlying mechanism of its action remains largely unknown. Moreover, details on i...

Qingqing Zhao, Wei He, Zhouheng Liu, Liangliang Huang, **aoli Yang… in Cell Death Discovery (2023)

Article

VH-CH1 switch region-inserting multispecific antibody designs and their efficacy against SARS-CoV-2 in vitro and in vivo

Lili Wu, Yue Gao, Dandan Yu, Sheng Liu, Runchu Zhao, Dezhi Liu, Ling Xu… in Cell Discovery (2023)

Article

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible given that this transcription factor plays important roles ...

Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang… in Cell Death Discovery (2023)

Article

Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung

Group 2 innate lymphoid cells (ILC2s) are critical sources of type 2 cytokines and represent one of the major tissue-resident lymphoid cells in the mouse lung. However, the molecular mechanisms underlying ILC2...

Shasha Xu, Yu Zhang, **ngjie Liu, Huisheng Liu, **nya Zou, Linlin Zhang… in BMC Biology (2023)

Article

USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation

Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promo...

Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma… in Cell Death & Disease (2023)

Article

Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma

Obstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling, which could be modulated by autophagy, plays a key role in sev...

Jian ** Zhou, Yi Wang, Shi Qi Li, Jia Qi Zhang, Ying Ni Lin… in Cell Death Discovery (2023)

Article

The complete and fully-phased diploid genome of a male Han Chinese

Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid hu...

Chentao Yang, Yang Zhou, Yanni Song, Dongya Wu, Yan Zeng, Lei Nie… in Cell Research (2023)

Article

Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats

Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by...

**aoming Liu, Mengya Liu, Huan Liu, Hui Yuan, Yong Wang… in BMC Molecular and Cell Biology (2023)

Article

Ancient mitogenomes reveal a high maternal genetic diversity of Pleistocene woolly rhinoceros in Northern China

Woolly rhinoceros (Coelodonta antiquitatis) is a typical indicator of cold-stage climate that was widely distributed in Northern Hemisphere during the Middle-Late Pleistocene. Although a plethora of fossils have ...

Junxia Yuan, Guojiang Sun, Bo **ao, Jiaming Hu, Linying Wang… in BMC Ecology and Evolution (2023)

Article

Capturing the microbial dark matter in desert soils using culturomics-based metagenomics and high-resolution analysis

Deserts occupy one-third of the Earth’s terrestrial surface and represent a potentially significant reservoir of microbial biodiversity, yet the majority of desert microorganisms remain uncharacterized and are...

Shuai Li, Wen-Hui Lian, Jia-Rui Han, Mukhtiar Ali… in npj Biofilms and Microbiomes (2023)

Article

The fungal quorum-sensing molecule, farnesol, regulates the immune response of vaginal epithelial cells against Candida albicans

Farnesol is a Candida-secreted quorum-sensing molecule of great interest as a potential antifungal agent for serious and hardly curable infections—candidiasis, especially vulvovaginal candidiasis (VVC).

Ting Li, Zhao-Hui Liu, Lin-Yuan Fan, Zhan Zhang, Hui-Hui Bai… in BMC Microbiology (2023)

Article

Leading basic modes of spontaneous activity drive individual functional connectivity organization in the resting human brain

Spontaneous activity of the human brain provides a window to explore intrinsic principles of functional organization. However, most studies have focused on interregional functional connectivity. The principles...

** Chen, Haoda Ren, Zhonghua Tang, Ke Zhou, Liqin Zhou… in Communications Biology (2023)

Article

NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2

Liver fibrosis is caused by a variety of chronic liver injuries and has caused significant morbidity and mortality in the world with increasing tendency. Elucidation of the molecular mechanism of liver fibrosi...

Xue Ding, **n-Le Zhu, Dong-Hui Xu, Shuang Li, Qiong Yang, **an Feng… in Cell Death & Disease (2023)

Article

LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation

The N6-methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging player in RNA modification landscape and responsible for the deposition of m6A in a few transcripts. AURKA (aurora kinase A) has been c...

Yingchao Wang, Yue Zhong, **aoyuan Zheng, Niangmei Cheng, Yong Yang… in Cell Death Discovery (2023)

Article

LSM14B controls oocyte mRNA storage and stability to ensure female fertility

Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and stability in mammalian oogenesis remains elusive. Here we showed...

Li-Ying Shan, Yu Tian, Wen-**ang Liu, Hai-Tao Fan… in Cellular and Molecular Life Sciences (2023)

Article

Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration. Therefore,...

**aoling Zhang, **anling Cong, **angting **, Yu’e Liu, Tong Zhang… in Cell Death & Disease (2023)

Article

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...

He-Wei Jiang, Hong Chen, Yun-**ao Zheng, Xue-Ning Wang… in Science China Life Sciences (2023)

Article

GDCL-NcDA: identifying non-coding RNA-disease associations via contrastive learning between deep graph learning and deep matrix factorization

Non-coding RNAs (ncRNAs) draw much attention from studies widely in recent years because they play vital roles in life activities. As a good complement to wet experiment methods, computational prediction metho...

Ning Ai, Yong Liang, Haoliang Yuan, Dong Ouyang, Shengli **e, **aoying Liu in BMC Genomics (2023)