307 Result(s)
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Open AccessSystematic identification and evolutionary features of rhesus monkey small nucleolar RNAs
Recent studies have demonstrated that non-protein-coding RNAs (npcRNAs/ncRNAs) play important roles during eukaryotic development, species evolution, and in the etiology of disease. Rhesus macaques are the mos...
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Open AccessSPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C
Salmonella paratyphi C is one of the few human-adapted pathogens along with S. typhi, S. paratyphi A and S. paratyphi B that cause typhoid, but it is not clear whether these bacteria cause the disease by the same...
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Open AccessInland post-glacial dispersal in East Asia revealed by mitochondrial haplogroup M9a'b
Archaeological studies have revealed a series of cultural changes around the Last Glacial Maximum in East Asia; whether these changes left any signatures in the gene pool of East Asians remains poorly indicate...
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Open AccessIdentification of two linear B-cell epitopes from West Nile virus NS1 by screening a phage-displayed random peptide library
The West Nile virus (WNV) nonstructural protein 1 (NS1) is an important antigenic protein that elicits protective antibody responses in animals and can be used for the serological diagnosis of WNV infection. A...
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Open AccessHypoxia-mimetic agents inhibit proliferation and alter the morphology of human umbilical cord-derived mesenchymal stem cells
The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therape...
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Open AccessA complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system
Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing r...
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Open AccessCharacterization of transcriptome dynamics during watermelon fruit development: sequencing, assembly, annotation and gene expression profiles
Cultivated watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai var. lanatus] is an important agriculture crop world-wide. The fruit of watermelon undergoes distinct stages of development with dramatic changes ...
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The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation
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Open AccessGeSICA: Genome segmentation from intra-chromosomal associations
Various aspects of genome organization have been explored based on data from distinct technologies, including histone modification ChIP-Seq, 3C, and its derivatives. Recently developed Hi-C techniques enable t...
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Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
Toll-like receptor 9 (TLR9) senses microbial DNA in the endosomes of plasmacytoid dendritic cells (pDCs) and triggers MyD88-dependent type I interferon (IFN) responses. To better understand TLR9 biology in pDC...
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Open AccessImmunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis
This study investigated the therapeutic effects of interleukin (IL)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF) co-administrated with antibacterial agents isoniazid (INH) and rifampin (RIF)...
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Open AccessSustained local delivery of insulin for potential improvement of peri-implant bone formation in diabetes
Dental implantation is an effective standard treatment modality to restore missing teeth and maxillofacial defects. However, in diabetics there is an increased risk for implant failure due to impaired peri-imp...
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Piglets cloned from induced pluripotent stem cells
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Open AccessIdentification of medium-sized genomic deletions with low coverage, mate-paired restricted tags
Genomic deletions are known to be widespread in many species. Variant sequencing-based approaches for identifying deletions have been developed, but their powers to detect those deletions that affect medium-si...
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Open AccessFolate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas
Invasive nonfunctional pituitary adenomas (NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control ...
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Open AccessSequencing and automated whole-genome optical map** of the genome of a domestic goat (Capra hircus)
An instrument for whole-genome optical map** is used to assemble the genome of the domestic goat into super-long scaffolds.
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Open AccessCrystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14
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Open AccessCharacterization of human plasma-derived exosomal RNAs by deep sequencing
Exosomes, endosome-derived membrane microvesicles, contain specific RNA transcripts that are thought to be involved in cell-cell communication. These RNA transcripts have great potential as disease biomarkers....
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Open AccessAn ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants
Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly to the PYR/PYL family of ABA receptors, resulting in inhibition of type 2C phosphat...
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Open AccessMolecular footprints of domestication and improvement in soybean revealed by whole genome re-sequencing
Artificial selection played an important role in the origin of modern Glycine max cultivars from the wild soybean Glycine soja. To elucidate the consequences of artificial selection accompanying the domestication...
