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Article
MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding
The dynamic interaction between tumor cells and their microenvironment induces a proinflammatory milieu that drives cancer development and progression. The S100A8/A9 complex has been implicated in chronic infl...
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Article
Open AccessDramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene
For expression of genes in mammalian cells, various vectors have been developed using promoters including CMV, EF-1α, and CAG promoters and have been widely used. However, such expression vectors sometimes fai...
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Article
Retroperitoneal bronchogenic cyst: a rare incidentaloma discovered in a juvenile hypertensive patient
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Article
Could salvage surgery after chemotherapy have clinical impact on cancer survival of patients with metastatic urothelial carcinoma?
The clinical impact of salvage surgery after chemotherapy on cancer survival of patients with metastatic urothelial carcinoma is controversial. We aimed to verify the clinical role of salvage surgery by analyz...
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Article
Laparoscopic management of complicated urachal remnants in adults
The traditional surgical approach for removing a urachal remnant is via a large transverse or midline infraumbilical incision. We review our experience with laparoscopic urachal cyst excision and report the ef...
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Article
The clinical impact of pathological review on selection the treatment modality for localized prostate cancer in candidates for brachytherapy monotherapy
To evaluate the impact of pathological review by pathologist with genitourinary expertise (PGU) on treatment modality of localized prostate cancer, we analyzed Gleason grade (GG) migration and the final treatm...
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Article
Implications of transcriptional factor, OCT-4, in human bladder malignancy and tumor recurrence
OCT-4, which is also known as POU5f1, is a key regulator of self-renewal in embryonic stem cells. The new cancer stem cell concept proposes that the expression of such genes is potentially correlated with tumo...
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Article
Open AccessDNA methylation status of REIC/Dkk-3 gene in human malignancies
The REIC (reduced expression in immortalized cells)/Dkk-3 is down-regulated in various cancers and considered to be a tumor suppressor gene. REIC/Dkk-3 mRNA has two isoforms (type-a,b). REIC type-a mRNA has shown...
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Article
Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma
To determine the independent risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC).
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Article
Unexpected occurrence of adrenal Cushing’s syndrome in a patient with systemic lupus erythematosus
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Article
Two instillations of epirubicin as prophylaxis for recurrence after transurethral resection of Ta and T1 transitional cell bladder cancer: a prospective, randomized controlled study
Although transurethral resection (TUR) is the standard treatment for non-muscle-invasive bladder tumors, 40–80% of tumors recur in spite of complete resection.
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Article
A randomized phase II trial of personalized peptide vaccine plus low dose estramustine phosphate (EMP) versus standard dose EMP in patients with castration resistant prostate cancer
Personalized peptide vaccination (PPV) combined with chemotherapy could be a novel approach for many cancer patients. In this randomized study, we evaluated the anti-tumor effect and safety of PPV plus low-dos...
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Article
Primary Aldosteronism Caused by a Unilateral Adrenal Adenoma Accompanied by Autonomous Cortisol Secretion
A 35-year-old Japanese woman was referred for further examination of persistent hypertension with hypokalemia. Her serum aldosterone levels were high and her plasma renin activity markedly suppressed. Radiolog...
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Chapter
Targeting Energy-Assisted Gene Delivery in Urooncology
Applications of energy sources which were applied for endourology is discussed with special reference to efficient targeting gene delivery for the treatment of urological cancer. Gene therapy has attracted att...
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Chapter
Therapeutic Potential of Adenovirus Mediated Interleukin-12 Gene Therapy for Prostate Cancer
Prostate cancer is characterized by extreme heterogeneity and multifocality of the primary tumour. The available clinical, pathological and molecular data suggest a lack of substantial clonal expansion at the ...
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Chapter and Conference Paper
Common and Uncommon Complications Related to ESWL
Extracorporeal shock wave lithotripsy (ESWL) is one of the most common urologic procedures performed today. Although it is a minimally invasive procedure, there has been a wide spectrum of injuries to the kidn...
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Article
Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer
Adenovirus-mediated transduction of the herpes simplex thymidine kinase gene (HSV-tk) in conjunction with ganciclovir (GCV) has been shown to result in significant growth suppression and to enhance survival in a ...
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Article
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells
Although prostate cancer cells are often initially sensitive to androgen ablation, they eventually lose this response and continue to survive, grow and spread in the absence of androgenic steroid...
