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Article
Open AccessOverexpression of M3 Muscarinic Receptor Is a Novel Strategy for Preventing Sudden Cardiac Death in Transgenic Mice
The present study was designed to investigate the cardiac benefits of M3 muscarinic receptor (M3-mAChR) overexpression and whether these effects are related to the regulation of the inward rectifying K+ channel b...
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Article
Microstructural features and properties of high-hardness and heat-resistant dispersion strengthened copper by reaction milling
The oxide dispersion strengthened copper alloys are attractive due to their excellent combination of thermal and electrical conductivities, high-temperature strength and microstructure stability. To date, the ...
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Article
Open AccessmiRNAs at the heart of the matter
Cardiovascular disease is among the main causes of morbidity and mortality in developed countries. The pathological process of the heart is associated with altered expression profile of genes that are importan...
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Article
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3′-untranslated regio...
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Article
Regulation of N-myristoyltransferase by novel inhibitor proteins
N-myristoylation ensures the proper function and intracellular trafficking of proteins. Many proteins involved in a wide variety of signaling, including cellular transformation and oncoge...
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Article
Expression of N-myristoyltransferase in Human Brain Tumors
N-myristoylation is a process of covalent irreversible protein modification that promotes association of proteins with membranes. Based on our previous findings of elevated N-myristoyltransferase (NMT) activit...
