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Article
Open AccessSelective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats
Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes du...
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Article
Open AccessGrape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression
Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU)...
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Article
Open AccessBlockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord
Tolerance induced by morphine remains a major unresolved problem and significantly limits its clinical use. Recent evidences have indicated that dopamine D2 receptor (D2DR) is likely to be involved in morphine...
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Article
Open AccessProcyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
The development of antinociceptive tolerance following repetitive administration of opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spi...
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Article
Electrospun PET/PEG Fibrous Membrane with Enhanced Mechanical Properties and Hydrophilicity for Filtration Applications
In this study, polyethylene glycol (PEG)-reinforced polyethylene terephthalate (PET) fibrous membranes were fabricated by electrospinning technique. The PEG was incorporated into the PET matrix at fixed ratios...
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Article
Open AccessAn in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor
Long-term potentiation (LTP), a much studied cellular model of synaptic plasticity, has not been demonstrated at synapses between primary afferent C-fibers and spinal dorsal horn (DH) neurons in mice in vivo. Eph...
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Article
Open AccessTargeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice
EphB receptor tyrosine kinases, which play important roles in synaptic connection and plasticity during development and in matured nervous system, have recently been implicated in processing of pain after nerv...
