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Open AccessAstragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy
Aberrant endoplasmic reticulum (ER) stress and autophagy are associated with diabetic nephropathy. Here we investigated the effect of astragaloside IV (AS-IV) on the progression of diabetic nephropathy (DN) an...
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Article
Open AccessA clinical investigation treating different types of fibroids identified by MRI-T2WI imaging with ultrasound guided high intensity focused ultrasound
Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This ...
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Article
Open AccessInfluences of anthropogenic land use on microbial community structure and functional potentials of stream benthic biofilms
Stream ecosystems are the primary receivers of nutrient and organic carbon exported from terrestrial ecosystems and are profoundly influenced by the land use of the surrounding landscape. The aquatic impacts o...
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Article
Open AccessArchitecture of the native major royal jelly protein 1 oligomer
Honeybee caste development is nutritionally regulated by royal jelly (RJ). Major royal jelly protein 1 (MRJP1), the most abundant glycoprotein among soluble royal jelly proteins, plays pivotal roles in honeybe...
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Article
Open AccessDigital coding of mechanical stress in a dynamic covalent shape memory polymer network
Controlling stresses in materials presents many unusual opportunities for their engineering applications. The potential for current approaches is severely limited by the intrinsic tie between the stress and th...
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Article
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that activates innate i...
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Article
Open AccessNLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ
NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling...
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Article
Open AccessMethylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
Epstein-Barr virus (EBV) is associated with a number of diseases, including malignancies. Currently, it is not known whether patients with different EBV-associated diseases have different methylation profiles ...
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Article
Open AccessThe allotetraploid origin and asymmetrical genome evolution of the common carp Cyprinus carpio
Common carp (Cyprinus carpio) is an allotetraploid species derived from recent whole genome duplication and provides a model to study polyploid genome evolution in vertebrates. Here, we generate three chromosome-...
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Open AccessIntegrated Transcriptomics, Proteomics, and Glycomics Reveals the Association between Up-regulation of Sialylated N-glycans/Integrin and Breast Cancer Brain Metastasis
Breast cancer brain metastasis has been recognized as one of the central issues in breast cancer research. The elucidation of the processes and pathways that mediate this step will provide important clues for ...
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Open AccessIntroducing national osteopathy practice-based research networks in Australia and New Zealand: an overview to inform future osteopathic research
Both the Osteopathic Research Innovation Network (ORION) and the Osteopathy Research Connect-New Zealand (ORC-NZ) are practice-based research networks (PBRNs) recently established in Australia and New Zealand....
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Open AccessParabolic dependence of the drag coefficient on wind speed from aircraft eddy-covariance measurements over the tropical Eastern Pacific
In this study, we examine and present the relationship between drag coefficient and wind speed. We used an observational dataset that consists of 806 estimates of the mean flow and fluxes from aircraft eddy-co...
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Open AccessMicrobial community structure and functional properties in permanently and seasonally flooded areas in Poyang Lake
Water level fluctuations are an inherent feature regulating the ecological structures and functions of lakes. It is vital to understand the effects of water level fluctuations on bacterial communities and meta...
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Article
Open Access2D MXene-Based Materials for Electrocatalysis
MXenes, as an emerging 2D material, are expected to exert a great influence on future energy storage and conversion technologies. In this review, we systematically summarize recent advances in MXene-based mate...
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Article
Open AccessThe study of automatic machine learning base on radiomics of non-focus area in the first chest CT of different clinical types of COVID-19 pneumonia
To explore the possibility of predicting the clinical types of Corona-Virus-Disease-2019 (COVID-19) pneumonia by analyzing the non-focus area of the lung in the first chest CT image of patients with COVID-19 b...
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Article
Open AccessUpcycling of dynamic thiourea thermoset polymers by intrinsic chemical strengthening
Thermoset polymers are indispensable but their environmental impact has been an ever-increasing concern given their typical intractability. Although concepts enabling their reprocessing have been demonstrated,...
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Article
Open AccessClinical and genomic features of Chinese lung cancer patients with germline mutations
The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 11...
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Article
Open AccessLearning aerodynamics with neural network
We propose a neural network (NN) architecture, the Element Spatial Convolution Neural Network (ESCNN), towards the airfoil lift coefficient prediction task. The ESCNN outperforms existing state-of-the-art NNs ...
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Article
Open AccessA natural uORF variant confers phosphorus acquisition diversity in soybean
Phosphorus (P) is an essential element for all organisms. Because P fertilizers are a non-renewable resource and high fixation in soils, sustainable agriculture requires researchers to improve crop P acquisiti...
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Article
Open AccessNeuromorphic device based on silicon nanosheets
Silicon is vital for its high abundance, vast production, and perfect compatibility with the well-established CMOS processing industry. Recently, artificially stacked layered 2D structures have gained tremendo...