-
Article
Open AccessPower and optimal study design in iPSC-based brain disease modelling
Studies using induced pluripotent stem cells (iPSCs) are gaining momentum in brain disorder modelling, but optimal study designs are poorly defined. Here, we compare commonly used designs and statistical analy...
-
Article
Open AccessBurden of gastroesophageal reflux disease in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of disease study 2019
For effective preventive strategies against GORD (gastro-esophageal reflux disease), we assessed the GORD burden from 1990 to 2019.
-
Article
Open AccessLow awareness of venous thromboembolism among neurosurgical hospitalized patients: a cross-sectional study
Venous thromboembolism (VTE) including Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE), is a serious cause of patient morbidity and mortality in hospitals. Neurosurgical hospitalized patients have hig...
-
Article
Open AccessBMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma
Fine particulate matter (PM2.5) is associated with increased incidence and severity of asthma. PM2.5 exposure disrupts airway epithelial cells, which elicits and sustains PM2.5-induced airway inflammation and ...
-
Article
Open AccessProjected transverse momentum resummation in top-antitop pair production at LHC
The transverse momentum distribution of the t t ¯ ...
-
Article
Author Correction: Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle
-
Article
Open AccessSpatio-temporal evolution characteristics and mitigation path of carbon dioxide emission from China’s wood and bamboo processing industry
Quantifying carbon dioxide (CO2) emissions from China’s wood and bamboo processing industry is associated with China’s emissions reduction targets, as well as mitigating global climate change. This study employed...
-
Article
Open AccessProteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 pro...
-
Article
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
-
Article
Open AccessCDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis
Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is sti...
-
Article
Open AccessCorrection: 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase
-
Article
Correction to: FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis
-
Article
Open AccessHuman adenovirus (HAdV) infection in children with acute respiratory tract infections in Guangzhou, China, 2010–2021: a molecular epidemiology study
Human adenovirus (HAdV) infection can cause a variety of diseases. It is a major pathogen of pediatric acute respiratory tract infections (ARIs) and can be life-threatening in younger children. We described th...
-
Article
The impacts of climate change on bank performance: What’s the mediating role of natural disasters?
This research estimates the effect of climate change on bank performance by considering the mediating role of natural disasters via unbalanced panel data from 2005 to 2018 in 127 countries. Moreover, this pape...
-
Article
Open AccessCorrection: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway
-
Article
Open AccessDistinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia
Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. ...
-
Article
Open AccessExcess ribosomal protein production unbalances translation in a model of Fragile X Syndrome
Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX). The mGluR Theory of FX predicts that pathological synaptic changes arise from the excessive translation of mRNAs downst...
-
Article
Open AccessShear behavior of sliding zone soil of loess landslides via ring shear tests in the South **gyang Plateau
Since the 1970s, a large number of loess collapses and landslides have occurred in the Loess Plateau of China due to water diversion and irrigation projects. A large amount of ancient landslide deposits are ac...
-
Article
Open AccessImpact of fertility on the longevity of older rural Chinese women: an analysis of a longitudinal survey
This study evaluates the impact of fertility during the childbearing period on the longevity of older rural Chinese women and verifies whether any trade-off exists between women’s longevity and their number of...
-
Article
Open AccessClinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)
Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Tran...
