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Article
Thermal environment shapes cuticle melanism and melanin-based immunity in the ground cricket Allonemobius socius
The thermal melanin hypothesis posits that ectothermic individuals of larger size or from colder environments exhibit darker cuticles due to melanin’s efficacy in absorbing solar radiation. However, melanin is...
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Chapter and Conference Paper
Applying Semantic Technologies to Public Sector: A Case Study in Fraud Detection
Fraudulent claims cost both the public and private sectors an enormous amount of money each year. The existence of data silos is considered one of the main barriers to cross-region, cross-department, and cross...
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Article
Open AccessThe BioLexicon: a large-scale terminological resource for biomedical text mining
Due to the rapidly expanding body of biomedical literature, biologists require increasingly sophisticated and efficient systems to help them to search for relevant information. Such systems should account for ...
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Article
IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo
Interleukin-17E (IL-17E) belongs to a novel family of cytokines that possess significant homology to IL-17. IL-17E has potent inflammatory effects in vitro and in vivo. Overexpression of IL-17E in mice results...
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Article
Open AccessRisk factors for human infection with West Nile Virus in Connecticut: a multi-year analysis
The optimal method for early prediction of human West Nile virus (WNV) infection risk remains controversial. We analyzed the predictive utility of risk factor data for human WNV over a six-year period in Conne...
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Article
Virulizin® induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors
Virulizin® has demonstrated strong antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. Our previous studies ha...
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Article
Open AccessAssessment of disease named entity recognition on a corpus of annotated sentences
In recent years, the recognition of semantic types from the biomedical scientific literature has been focused on named entities like protein and gene names (PGNs) and gene ontology terms (GO terms). Other sema...
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Article
Reproductible production of a PEGylated dual-acting peptide for diabetes
A pEGylated glucagon-like peptide-1 (GLP-1) agonist and glucagon antagonist hybrid peptide was engineered as a potential treatment for type 2 diabetes. To support preclinical development of this PEGylated dual...
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Article
Open AccessGOAnnotator: linking protein GO annotations to evidence text
Annotation of proteins with gene ontology (GO) terms is ongoing work and a complex task. Manual GO annotation is precise and precious, but it is time-consuming. Therefore, instead of curated annotations most o...
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Article
Virulizin, a novel immunotherapy agent, activates NK cells through induction of IL-12 expression in macrophages
Virulizin, a novel biological response modifier, has demonstrated significant antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cance...
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Article
Open AccessAn evaluation of GO annotation retrieval for BioCreAtIvE and GOA
The Gene Ontology Annotation (GOA) database http://www.ebi.ac.uk/GOA aims to provide high-quality supplementary GO annotation to proteins in the UniProt Know...
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Article
NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin
Previous studies have demonstrated antitumor efficacy of Virulizin in several human tumor xenograft models and a critical role for macrophages in the antitumor mechanism of Virulizin. Although there is growing...
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Article
Creating New Enzymes With Chemistry
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Article
French Science Salutes Biotechnology
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Article
New Trends in Financing Biotechnology
Patterns of biotechnology financing have undergone subtle shifts in recent months, and the shifts are an indication that the industry is moving from childhood into adolescence. Once the central source of suppo...
