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Article
Bat-borne virus diversity, spillover and emergence
Most viral pathogens in humans have animal origins and arose through cross-species transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus, Nipah virus, Hendra virus, severe...
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Article
Open AccessProtective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with a case fatality rate close to 40%, but for which no vaccines are availabl...
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Article
SARS and MERS: recent insights into emerging coronaviruses
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that can cause seve...
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Article
Open AccessReplication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses. Investigations into the origin of MERS-CoV have focused on two potential reservoirs...
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Article
Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate t...
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Article
Open AccessInhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
The identification of a novel β coronavirus, nCoV, as the causative agent of severe respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised concerns about the possibility of a co...
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Article
Open AccessRapid Nipah virus entry into the central nervous system of hamsters via the olfactory route
Encephalitis is a hallmark of Nipah virus (NiV) infection in humans. The exact route of entry of NiV into the central nervous system (CNS) is unknown. Here, we performed a spatio-temporal analysis of NiV entry...
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Article
The immune response to Nipah virus infection
Nipah virus has recently emerged as a zoonotic agent that is highly pathogenic in humans. Outbreaks have occurred regularly over the last two decades in South and Southeast Asia, where mortality rates reach as...
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Article
Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies
Since its discovery in 1976, Ebolavirus has caused periodic outbreaks of viral hemorrhagic fever associated with severe and often fatal disease. Ebolavirus is endemic in Central Africa and the Philippines. Alt...
