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Article
Open AccessPredictive model for the preoperative assessment and prognostic modeling of lymph node metastasis in endometrial cancer
Lymph node metastasis (LNM) is a well-established prognostic factor in endometrial cancer (EC). We aimed to construct a model that predicts LNM and prognosis using preoperative factors such as myometrial invas...
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Article
Open AccessAssociation between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction
We clarified the association between changes in the number of foundational medications for heart failure (FMHF) during hospitalization for worsening heart failure (HF) and post-discharge prognosis. We retrospe...
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Article
Open AccessPhasing analysis of lung cancer genomes using a long read sequencer
Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct the phasing analysis of non-small cell lung cancer specimens of 20 Japanese patients. By the combinatory use of short and l...
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Article
Sleep-disordered breathing is independently associated with elevated natriuretic peptide levels in patients with cardiovascular diseases
Sleep disorders and sleep duration have attracted considerable attention as potential modifiable risk factors for the development and progression of heart failure (HF). However, whether these sleep behaviors c...
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Article
Open AccessPotential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction
Malnutrition is common in patients with heart failure with reduced ejection fraction (HFrEF) and may influence the long-term prognosis and allocation of combination medical therapy. We reviewed 1231 consecutiv...
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Article
Open AccessHigh prevalence of occult left ventricular diastolic dysfunction detected by exercise stress test in systemic sclerosis
Despite the poor prognosis of systemic sclerosis (SSc) due to the co-occurrence of left ventricular diastolic dysfunction (LVDD), presence of occult LVDD has not been sufficiently investigated. This retrospect...
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Article
Open AccessScaling advantage of chaotic amplitude control for high-performance combinatorial optimization
The development of physical simulators, called Ising machines, that sample from low energy states of the Ising Hamiltonian has the potential to transform our ability to understand and control complex systems. ...
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Article
Open AccessTemporal trends in tolvaptan use after revision of national heart failure guidelines in Japan
Within no definite diuretic protocol for acute heart failure (AHF) patients and its variation in regional clinical guidelines, the latest national guidelines in Japan commends use of tolvaptan in diuretic-resi...
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Article
Open AccessTP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer
Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlat...
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Article
Open AccessDistribution of genetic alterations in high-risk early-stage cervical cancer patients treated with postoperative radiation therapy
Somatic genetic alteration analysis was performed for post-hysterectomy high-risk early-stage uterine cervical cancer patients who underwent post-operative radiation therapy. Post-operative radiation therapy w...
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Article
Open AccessClinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)
To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published “Clinical practic...
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Article
Open AccessPatient participation and associated factors in the discussions on do-not-attempt-resuscitation and end-of-life disclosure: a retrospective chart review study
Patient participation is a key foundation of advance care planning (ACP). However, a patient himself/herself may be left out from sensitive conversations such as end-of-life (EOL) care discussions. The objecti...
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Article
Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults
Homologous recombination deficiency (HRD), which influences the efficacy of PARP inhibitor- and platinum agent-based therapies, is a prevalent phenotype of breast cancer in adolescents and young adults (AYAs; ...
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Article
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) wit...
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Article
Precision medicine for ovarian clear cell carcinoma based on gene alterations
Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this diseas...
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Article
Open AccessCharacterization of cancer omics and drug perturbations in panels of lung cancer cells
To better understand the disruptions of transcriptional regulations and gene expression in lung cancers, we constructed a multi-omics catalogue of the responses of lung cancer cells to a series of chemical com...
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Article
Length of hospital stay and its impact on subsequent early readmission in patients with acute heart failure: a report from the WET-HF Registry
Heart failure (HF) is characterized by frequent rehospitalization and prolonged hospital stay. Although length of stay has been used as a surrogate marker for hospital performance, its association with early r...
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Article
Discrepancy between patient-reported quality of life and the prognostic assessment of Japanese patients hospitalized with acute heart failure
Patient-reported quality of life (PRQL) is a primary therapeutic target for patients with chronic heart failure (HF) and is associated with long-term prognosis. However, its utility in hospitalized HF (HHF) pa...
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Article
High-grade glioneuronal tumor with an ARHGEF2–NTRK1 fusion gene
Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected ...
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Article
Increasing mixed venous oxygen saturation is a predictor of improved renal function after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension
Balloon pulmonary angioplasty (BPA) has emerged as an effective treatment for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Renal function has been identified as a prognostic ...
