27 Result(s)

Article

Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and ⁴⁵Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation

The effects of adrenaline (2.2×10⁻⁶ M) and cyclic N⁶-2′-O-dibutyryl-adenosine-3′,5′-monophosphate (DB-c-AMP; 10⁻³ M) on mechanical performance, ⁴⁵Ca uptake and total tissue calcium concentration were investigated...

T. Meinertz, H. Nawrath, H. Scholz in Naunyn-Schmiedeberg's Archives of Pharmacology (1973)

Article

Adrenaline, DB-c-AMP and myocardial ⁴⁵Ca exchange. Comparative studies in rat and guinea-pig auricles

The positive inotropic effect of adrenaline has been assumed to result from an increase in the intracellular level of c-AMP which, in turn, might enhance the permeability of the cardiac cell membrane to Ca²⁺. In ...

T. Meinertz, H. Nawrath, H. Scholz in Naunyn-Schmiedeberg's Archives of Pharmacology (1973)

Article

Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides

This study was designed to further elucidate relevance and mechanism of the positive inotropic action of cyclic N⁶-2′-O-dibutyryl-AMP (DB-c-AMP). For this purpose the effects of cyclic N⁶-monobutyryl-AMP (N⁶-MB-c...

T. Meinertz, H. Nawrath, H. Scholz in Naunyn-Schmiedeberg's Archives of Pharmacology (1973)

Article

Dibutyryl cyclic AMP and adrenaline increase contractile force and ⁴⁵Ca uptake in mammalian cardiac muscle

The effects of dibutyryl cyclic AMP (DB-AMP; 10⁻³M) and adrenaline (2.2×10⁻⁶ M) on contractile force, ⁴⁵Ca uptake, and total myocardial Ca concentration were investigated in electrically driven left auricles isol...

T. Meinertz, H. Nawrath, H. Scholz in Naunyn-Schmiedeberg's Archives of Pharmacology (1973)

Article

Über den Einfluß von Mn⁺⁺-Ionen auf die positiv inotrope Wirkung einiger Pharmaka an isolierten Meerschweinchenvorhöfen

T. Meinertz, H. Scholz in Naunyn-Schmiedebergs Archiv für Pharmakologie (1969)

Article

Über den Einfluß von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorhöfen

The influence of bivalent manganese ions (Mn⁺⁺) on the positive inotropic effect of adrenaline, theophylline, and digitoxigenin was studied in isolated, electrically driven left guinea-pig auricles in phosphate-f...

T. Meinertz, H. Scholz in Naunyn-Schmiedebergs Archiv für Pharmakologie (1969)

Chapter

Über den Einfluß von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorhöfen

The influence of bivalent manganese ions (Mn⁺⁺ ) on the positive inotropic effect of adrenaline, theophylline, and digitoxigenin was studied in isolated, electrically driven left guinea-pig auricles in phosphate-...

T. Meinertz, H. Scholz in Naunyn Schmiedebergs Archiv für Pharmakologie (1969)