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Article
Spatial Variation of Aquifer Permeability in the North China Plain from Large Magnitude Earthquake Signals
Permeability changes induced by earthquakes have been studied widely. However, basic questions still remain: what are the spatial differences in permeability changes induced by far-field earthquakes? Is there ...
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Article
Enhanced Corrosion Resistance in High-Strength Biodegradable Mg-Zn-Ca-Si Glassy Alloy Composite via Preparation of a Self-Sealing Plasma Electrolytic Oxidation Layer
In this study, a dendrites reinforced Mg85.9Zn12Ca2Si0.1 glassy alloy composite was fabricated through rapid solidification. After self-sealing plasma electrolytic oxidation (PEO) treatment, the glassy alloy comp...
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Article
Open AccessA new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension
Inflammation and dysregulated immunity play vital roles in idiopathic pulmonary arterial hypertension (IPAH), while the mechanisms that initiate and promote these processes are unclear.
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Article
Open AccessIGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway
Circular RNAs (circRNAs) represent a class of covalently closed, single-stranded RNAs and have been linked to cancer progression. N6-methyladenosine (m6A) methylation is a ubiquitous RNA modification in cancer ce...
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Article
Quantification of testicular fat content: the value of evaluating testicular function after cryptorchidism surgery
To investigate the correlation between testicular fat content (TFC) and sex hormone levels in patients with cryptorchidism and its value in assessing postsurgical testicular function.
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Article
Open AccessExonuclease editor promotes precision of gene editing in mammalian cells
Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging.
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Article
Open AccessA real-world pharmacovigilance study of FDA adverse event reporting system events for Capmatinib
Capmatinib is a potent selective mesenchymal-epithelial transition inhibitor approved in 2020 for the treatment of metastatic non-small cell lung cancer. As real-world evidence is very limited, this study eval...
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Article
Open AccessIL-1β promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K/AKT pathway
Esophageal cancer is a common type of cancer that poses a significant threat to human health. While the pro-inflammatory cytokine IL-1β has been known to contribute to the development of various types of tumor...
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Article
A novel target to turn cold tumors into hot tumors: lysosomal 25-hydroxycholesterol activates AMPKα and immunosuppressive tumor-associated macrophages
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Article
Open AccessPhenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK
The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor act...
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Article
Interannual variability of diurnal temperature range in CMIP6 projections and the connection with large-scale circulation
Diurnal temperature range (DTR), as a core indicator of the Earth system, exhibits obvious temporal and spatial variations, which is not entirely consistent over global. The historical simulation capabilities ...
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Article
Open AccessGenomic landscape and distinct molecular subtypes of primary testicular lymphoma
Primary testicular lymphoma (PTL) is a rare lymphoma predominantly occurring in the elderly male population. It is characterized by a limited response to treatment and a heightened tendency towards relapse. Hi...
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Article
Structure feature and compressive crushing behavior of lightweight clay aggregate particle: experiments and numerical simulations
Lightweight expanded clay aggregate (LECA) is a lightweight granular material, which can be used as an ideal backfilling geomaterial attributed to its porous particles. Through X-ray tomography images, it is f...
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Article
Open AccessApplication of micro-substance tracer test in fractured horizontal wells
This paper delves into a novel micro-substance tracer test in fractured horizontal well C-15. The experimental results are highly encouraging as they demonstrate that the trace material tracer is capable of sa...
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Article
A Phase I Clinical Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of GB221 Injection and Trastuzumab (Herceptin®) in Healthy Chinese Adults
GB221 is a recombinant humanized anti-HER2 monoclonal antibody. The purpose of this study was to evaluate the pharmacokinetic, safety, and immunogenicity of GB221 in healthy Chinese adults in comparison to tra...
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Article
Preparation of zirconia/zinc oxide nanocomposites by sol-gel method for highly sensitive determination of dopamine
A novel electrochemical sensor utilizing ZrO2 and ZnO hybrid nanocomposites was developed for the specific detection of dopamine (DA) with ultra-high sensitivity and selectivity. The structure and electrochemical...
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Article
Highly efficient fog harvesting system achieved on slippery micro-grooved cones
The directional transport of liquid droplets on asymmetrical one-dimensional surfaces has broad applicability, from fog harvesting and oil/water separation to desalination, sensing, and beyond. The balance bet...
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Article
Correction: An Emotional Skills Intervention for Elementary Children with Autism in China: A Pilot Study
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Article
Open AccessSmall animal PET imaging with the 68Ga-labeled pH (low) insertion peptide-like peptide YJL-4 in a triple-negative breast cancer mouse model
The aim of this study was to prepare a novel 68Ga-labeled pH (low) insertion peptide (pHLIP)-like peptide, YJL-4, and determine its value for the early diagnosis of triple-negative breast cancer (TNBC) via in viv...
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Article
Open AccessEnhancing prime editor flexibility with coiled-coil heterodimers
Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the large size of pr...
