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Article
Immunosuppressive MFAP2+ cancer associated fibroblasts conferred unfavorable prognosis and therapeutic resistance in gastric cancer
To explore the predictive merit of MFAP2+ cancer associated fibroblasts (CAFs) infiltration for clinical outcomes and adjuvant chemotherapy or immunotherapy responsiveness in gastric cancer (GC).
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Article
Open AccessOutcome of chairside CAD/CAM ceramic restorations on endodontically treated posterior teeth: a prospective study
The aim of this study was to evaluate the outcome and risk factors for chairside CAD/CAM full cusp coverage restorations on endodontically treated posterior teeth after 3 years of follow-up.
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Article
Hepatoprotective Phenylpropanoid Glycosides from Highland Barley Monascus purpureus
A new phenylpropanoid glycoside, named 4-O-β-D-glucopyranosyl-7-phenyl-9-propenyl ketone-9-O-β-Dglucopyranosyl-(6′′→1′′′)-6′′-O-α-L-rhamnopyranose (1), and four known phenylpropanoid glycosides 2–5 were isolated ...
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Chapter and Conference Paper
Research on Electromagnetic Force Characteristics Based on Asymmetric 120° Pitch Figure-8 Coils in EDS System for Maglev Train
Insufficient suspension force of superconducting electrodynamic suspension (EDS) system at low speed is an important problem in the construction of maglev trains. The structure of the figure-8 ground coil play...
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Article
Open AccessUmbrella strategy with systemic and intraperitoneal chemotherapy versus systemic chemotherapy in patients with advanced gastric cancer: a multicenter, randomized Phase III clinical trial
We have developed a tridirectional regimen combining intraperitoneal, intravenous, and oral chemotherapy as a treatment for patients with advanced gastric cancer and individualized these chemotherapeutics acco...
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Article
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ
Cytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 consists of five isoforms (IL-37a-...
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Article
A prognostic nomogram and risk classification system of elderly patients with extraosseous plasmacytoma: a SEER database analysis
The survival trends and prognostic factors of patients with extraosseous plasmacytoma (EOP) or extramedullary plasmacytoma (EMP) have not been reported in recent years. The objective of this study was to devel...
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Article
Open AccessSingle-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism
Energy homeostasis is essential for the adaptation of animals to their environment and some wild animals keep low metabolism adaptive to their low-nutrient dietary supply. Giant panda is such a typical low-met...
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Article
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis
The gut microbiome is recognized as a key modulator of sepsis development. However, the contribution of the gut mycobiome to sepsis development is still not fully understood. Here, we demonstrated that the lev...
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Article
Adjuvant immune checkpoint inhibitors associated with higher recurrence-free survival in postoperative hepatocellular carcinoma (PREVENT): a prospective, multicentric cohort study
Adjuvant therapy may improve survival of patients with hepatocellular carcinoma (HCC) after curative resection. This study compared safety and efficacy outcomes between patients at high risk of recurrence who ...
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Article
Open AccessApplication of non-invasive prenatal testing to 91,280 spontaneous pregnancies and 3477 pregnancies conceived by in vitro fertilization
Many clinical studies based on spontaneous pregnancies (SPs) have demonstrated the superiority of non-invasive prenatal testing (NIPT), and the question of whether this technology is suitable for offspring con...
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Article
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy
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Article
Open AccessUltrasound-guided scalp nerve block in anesthesia of children receiving cranial suture reconstruction
Analgesia is very important for children with craniosynostosis who are undergoing cranial suture reconstruction. This study investigated the effectiveness and safety of an analgesic technique based on scalp ne...
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Article
Machinability study of cryogenic-ultrasonic vibration-assisted milling Inconel 718 alloy
A new machining method, cryogenic-ultrasonic vibration-assisted milling (CUVAM), is proposed to improve the workability of Inconel 718. This study examined the machining mechanism of CUVAM technology at differ...
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Article
Multifunctional sulfur-immobilizing GO/MXene aerogels for highly-stable and long-cycle-life lithium–sulfur batteries
Lithium-sulfur batteries are a promising candidate for next-generation energy storage due to their high theoretical energy density. However, S insulation and the lithium polysulfide intermediate's shuttle effe...
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Article
Open AccessImmune regulation and prognosis indicating ability of a newly constructed multi-genes containing signature in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy, although newly develo** targeted therapy and immunotherapy have been showing promising effects in clinical treatment, the effectiv...
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Article
Regenerative-Cooling Heat-Transfer Performance of Mg/CO2 Powder Rocket Engines for Mars Missions
Aimed at the problem of thermal protection due to the long-time operation of Mg/CO2 rocket engines under high pressure and heat flux, a regenerative-cooling heat-transfer model is established that considers liqui...
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Article
Open AccessA live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems
The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides a promising solution to support drug discovery, disease modeling, and regenerative medicine. However, functional...
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Article
Establishment of Agrobacterium-mediated transformation system to Juglans sigillata Dode ‘Qianhe-7’
An efficient genetic transformation system is of great significance for verifying gene function and improving plant breeding efficiency by gene engineering. In this study, a stable Agrobacterium mediated genetic ...
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Article
Study of chip adhesion behavior in titanium alloy dry milling process based on image extraction technology
This paper studied the chip adhesion behavior of titanium alloy Ti–6Al–4 V under different cutting parameters, and the image extraction technology was used to quantify the surface chip adhesion rate. The corre...
