34 Result(s)
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Article
Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study
Glatiramer acetate (GA) is an approved therapy for relapsing–remitting multiple sclerosis, but its efficacy for the prevention of attacks in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. We d...
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Open AccessVery late-onset neuromyelitis optica spectrum disorder beyond the age of 75
Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three...
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Open AccessPneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany
Long-term complications and a case mortality rate of 7.5% make meningitis caused by Streptococcus pneumoniae a serious clinical threat. In 2006, a general pneumococcal conjugate vaccination (PCV) recommendation w...
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Open AccessInterferon-β-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumab
Neuromyelitis optica (NMO) is a severely disabling inflammatory disorder of the central nervous system and is often misdiagnosed as multiple sclerosis (MS). There is increasing evidence that treatment options ...
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Open AccessProtein oxidative damage in the hippocampus in a mouse model of acute hyperammonemia
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Article
Assessment of microRNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis
Recent large-scale association studies have identified over 100 MS risk loci. One of these MS risk variants is single-nucleotide polymorphism (SNP) rs17066096, located ~14 kb downstream of IL22RA2. IL22RA2 repres...
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Open AccessUpdate on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)
Neuromyelitis optica (NMO, Devic’s syndrome), long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity. Major progress has been made in the diagnosis and treatmen...
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Characteristics of Susac syndrome: a review of all reported cases
Susac syndrome is an important differential diagnosis in many neurological disorders, but our understanding of this rare disease has largely been limited to reports of single cases and small case series. In th...
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Article
Open AccessAn emboligenic pulmonary abscess leading to ischemic stroke and secondary brain abscess
Ischemic stroke by septic embolism occurs primarily in the context of infective endocarditis or in patients with a right-to-left shunt and formation of a secondary cerebral abscess is a rare event. Erosion of ...
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Article
Independent replication of STAT3 association with multiple sclerosis risk in a large German case–control sample
Recent genome-wide association studies have implicated the “signal transducer and activator of transcription 3” gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent va...
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Fingolimod is a potential novel therapy for multiple sclerosis
Only moderately effective therapies are currently available for the treatment of multiple sclerosis (MS). New treatments for MS that have neuroprotective properties as well as anti-inflammatory effects are nee...
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Article
Development of oral cladribine for the treatment of multiple sclerosis
Multiple sclerosis (MS) is a chronic immune-mediated disorder of the CNS in which autoreactive CD4+ and CD8+ T lymphocytes, B lymphocytes, antibodies, macrophages and cytokines synergize to attack myelin sheat...
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Neuromyelitis and more: the unfolding spectrum of aquaporin 4-related neurological diseases
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Article
Revised diagnostic criteria for neuromyelitis optica—incorporation of NMO-IgG status
