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Article
Open AccessThe effect of two different GH dosages on final height and bone geometry
Growth hormone (GH) has a strong positive influence on bone, stimulating both bone elongation and increase in size. The aim of the study was to compare the effect of two different GH dosages on final height an...
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Article
Open AccessFive-year response to growth hormone in children with Noonan syndrome and growth hormone deficiency
Noonan syndrome (NS) is an autosomal dominant disorder characterized by specific features including short stature, distinctive facial dysmorphic features, congenital heart defects, hypertrophic cardiomyopathy,...
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Article
Open AccessHereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?
Osteochondroma generally occurs as a single lesion and it is not a heritable disease. When two or more osteochondroma are present, this condition represents a genetic disorder named hereditary multiple exostos...
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Article
Impact of health care providers’ advice on vaccine refusal for children with an acute nervous system infection
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Article
Open AccessAcute cerebellitis in varicella: a ten year case series and systematic review of the literature
Acute cerebellitis (AC) is the most common neurological complication of varicella. Nevertheless, it has been scarcely studied. The objective of this study were to asses the occurrence of AC among children hosp...
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Article
Open AccessSevere growth hormone deficiency and pituitary malformation in a patient with chromosome 2p25 duplication and 2q37 deletion
We report on a male child ascertained at 4.8 years of age with severe growth failure, growth hormone (GH) deficiency, psychomotor delay with prevalent speech impairment, and a distinct phenotype. An evaluation...
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Article
Open AccessMultiple cerebral sinus thromboses complicating meningococcal meningitis: a pediatric case report
Cerebral venous sinus thrombosis (CVT) is a rare and potentially life-threatening condition in the pediatric population. The clinical presentation is frequently nonspecific; thus diagnosis is often delayed or ...
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Article
Open AccessLate diagnosis of celiac disease in an asymptomatic infant with growth failure
The clinical spectrum for celiac disease (CD) is broad and includes cases with either typical (intestinal) or atypical (extraintestinal) features, often making the diagnosis of CD very difficult.
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Article
Open Access3-M syndrome associated with growth hormone deficiency: 18 year follow-up of a patient
3-M syndrome is a rare autosomal recessive disorder that causes short stature, unusual facial features and skeletal abnormalities. Mutations in the CUL7, OBSL1 and CCDC8 genes could be responsible for 3-M syndrom...
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Article
Open AccessMenstrual pattern and menstrual disorders among adolescents: an update of the Italian data
The most striking event in the whole process of female puberty is the onset of menstruation. To our knowledge, no large population-based studies have been performed on the topic of menstrual health among Itali...
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Growth Velocity Curves: What They Are and How to Use Them
Growth velocity charts are important to evaluate the growth of a subject and are available for height and weight, in both boys and girls. Height or weight velocity is a variable derived from the measurement of...
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Article
Efficacy of long-term growth hormone therapy in short children with reduced growth hormone biological activity
Aim: The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. Methods: In 12 GH-deficient (GHD) and 12 bioinac...
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Article
Open AccessTreatment adherence with the easypod™ growth hormone electronic auto-injector and patient acceptance: survey results from 824 children and their parents
Accurately monitoring adherence to treatment with recombinant human growth hormone (r-hGH) enables appropriate intervention in cases of poor adherence. The electronic r-hGH auto-injector, easypod™, automatical...
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Article
Open AccessRole of adiponectin and leptin on body development in infants during the first year of life
The control of growth and nutritional status in the foetus and neonate is a complex mechanism, in which also hormones produced by adipose tissue, such as adiponectin and leptin are involved. The aim of this st...
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Article
Poly-epiphyseal overgrowth: description of a previously unreported skeletal dysplasia
A skeletal dysplasia with previously unreported features is presented. Its evolution was characterized by growth abnormalities of bones without involvement of other organs. Advanced bone age, increased stature...
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Article
Smith-Magenis syndrome and growth hormone deficiency
Smith-Magenis syndrome (SMS) is a multiple congenital anomaly/mental retardation syndrome including physical and neurobehavioural features. The disease is commonly associated with a ca. 3.7 Mb interstitial del...
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Article
Growth Hormone Immunoreactivity Does Not Reflect Bioactivity
In childhood, the largest secretory burst of GH occurs during nighttime, and consists of a complex mixture of molecular forms of GH that are thought to have different biologic activity. Standard GH assays cann...
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Article
Circulating GH Isoforms and GH Bioactivity in Preterm Neonates
Among the molecular variants of human GH, the monomeric 22-kD is the predominant isoform, whereas the 20-kD is the second most abundant isoform. Because little is known on the pattern of human GH isoforms in t...
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Article
Immunization with Haemophilus influenzae Type b Conjugate Vaccine in Children Given Bone Marrow Transplantation: Comparison with Healthy Age-Matched Controls
Forty-seven patients (age range, 7 months–18 years)with malignant (38 cases) and nonmalignant (9 cases)disorders given an allogeneic or an autologous bone marrowtransplantation (BMT) were immunized with Haemophil...
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Article
95 NEONATAL EVOLUTION OF IGFs AND SERUM THYMIDINE ACTIVITY
Serum growth-promoting activity measured as 3H-THY incorporation into lymphocytes (TA) was measured simultaneously with RIA of IGFs I and II in the same samples of cord blood and of capillary blood collected 3...
