45 Result(s)
within
Matthew R. Cooperberg
English
-
Article
Open AccessDecipher identifies men with otherwise clinically favorable-intermediate risk disease who may not be good candidates for active surveillance
We aimed to validate Decipher to predict adverse pathology (AP) at radical prostatectomy (RP) in men with National Comprehensive Cancer Network (NCCN) favorable-intermediate risk (F-IR) prostate cancer (PCa), ...
-
Article
Validity of the National Death Index to ascertain the date and cause of death in men having undergone prostatectomy for prostate cancer
The National Death Index (NDI) is a centralized database containing information from death certificates that are frequently referenced by health and medical investigators to ascertain vital statistics. Yet, it...
-
Article
Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS)
For men on active surveillance for prostate cancer, biomarkers may improve prediction of reclassification to higher grade or volume cancer. This study examined the association of urinary PCA3 and TMPRSS2:ERG (...
-
Article
Impact of age, comorbidity, and PSA doubling time on long-term competing risks for mortality among men with non-metastatic castration-resistant prostate cancer
Understanding competing risks for mortality is critical in determining prognosis among men with non-metastatic castration-resistant prostate cancer (nmCRPC), a disease state that often affects older men and ha...
-
Article
Practice patterns of primary EBRT with and without ADT in prostate cancer treatment
Androgen deprivation therapy (ADT) has been shown to improve survival for men with intermediate and high-risk prostate cancer undergoing external-beam radiation therapy (EBRT). Using data from a community-base...
-
Article
First-year weight loss with androgen-deprivation therapy increases risks of prostate cancer progression and prostate cancer-specific mortality: results from SEARCH
We aimed to study the associations between androgen-deprivation therapy (ADT)-induced weight changes and prostate cancer (PC) progression and mortality in men who had undergone radical prostatectomy (RP).
-
Article
Open AccessHigh-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing
MicroRNAs hold great promise as biomarkers of disease. However, there are few efficient and robust methods for measuring microRNAs from low input samples. Here, we develop a high-throughput sequencing protocol...
-
Article
Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database
Systemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are cor...
-
Article
The use of PET/CT in prostate cancer
Positron emission tomography/computed tomography (PET/CT) has recently emerged as a promising diagnostic imaging platform for prostate cancer. Several radiolabelled tracers have demonstrated efficacy for cance...
-
Chapter
Prostate Cancer Markers
Diagnostic biomarkers derived from blood, urine, or prostate tissue provide additional information beyond clinical calculators to determine the risk of detecting high-grade prostate cancer. Once diagnosed, m...
-
Article
Epidemiology of prostate cancer
-
Article
Why the prostate arm of the PLCO trial failed and what it has taught us
Given a recent update from the PLCO trial reporting that over 90% of men in the 'usual care' arm underwent some degree of PSA testing, the PLCO can no longer accurately be called a trial of screening versus no...
-
Article
Clinical Utility of Biomarkers in Localized Prostate Cancer
A new generation of prostate cancer (PCa) biomarkers has emerged, including diagnostic serum and urine markers aimed at refining the identification high-grade tumors and tissue-based gene expression assays off...
-
Article
Long-term follow-up of International Prostate Symptom Score (IPSS) in men following prostate brachytherapy
To investigate variation in the International Prostate Symptom Score (IPSS) in men following prostate brachytherapy.
-
Article
A new look at prostate cancer treatment complications
A recent population-based analysis from Nam and coauthors found high complication rates occurring within 5 years of prostatectomy or radiation therapy interventions for prostate cancer. These findings emphasiz...
-
Article
Implications of the New AUA Guidelines on Prostate Cancer Detection in the U.S.
In 2012, the U.S. Preventive Services Task Force (USPSTF) issued a blanket “D” recommendation against all prostate-specific antigen (PSA)-based early detection efforts for prostate cancer, reflecting critical ...
-
Article
Risk-Based Prostate Cancer Screening: Who and How?
The purpose of this review is to identify clinical risk factors for prostate cancer and to assess the utility and limitations of our current tools for prostate cancer screening. Prostate-specific antigen is th...
-
Article
New types of radiotherapy improve cancer outcome but at what cost?
New and very expensive forms of radiotherapy, such as intensity-modulated radiation therapy and proton therapy, have taken over the localized prostate cancer market. But is there enough evidence to justify the...
-
Article
For localized prostate cancer, does technology equal progress?
Recent evolution of prostate cancer treatment reflects technological arms races driven by economic incentives rather than high-quality evidence—as exemplified by proton-beam radiation, recently found markedly ...
-
Article
Open AccessThe example of CaPSURE: lessons learned from a national disease registry
Although randomized controlled trials (RCTs) remain the gold standard for determining evidence-based clinical practices, large disease registries that enroll large numbers of patients have become paramount as ...
