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Open AccessErratum: Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia
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Open AccessEvidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia
A substantial fraction of familial colorectal cancer (CRC) and polyposis heritability remains unexplained. This study aimed to identify predisposing loci in patients with these disorders.
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Open AccessMendelian randomisation analysis strongly implicates adiposity with risk of develo** colorectal cancer
Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a...
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Open AccessRare disruptive mutations and their contribution to the heritable risk of colorectal cancer
Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinical...
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Open AccessGlycosylation of plasma IgG in colorectal cancer prognosis
In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans in 1229 CRC patients and corr...
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Open AccessCorrespondence: SEMA4A variation and risk of colorectal cancer
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Open AccessRecurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
Whilst common genetic variation in many non-coding genomic regulatory regions are known to impart risk of colorectal cancer (CRC), much of the heritability of CRC remains unexplained. To examine the role of re...
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Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer
Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. ...
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Open AccessA new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer
Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. ...
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Köttgen and colleagues report genome-wide association studies for serum urate in over 140,000 individuals from the Global Urate Genetics Consortium (GUGC). They identify 18 loci newly associated with seru...
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Open AccessStatin use and association with colorectal cancer survival and risk: case control study with prescription data linkage
In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is...
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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility ...
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Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Ian Tomlinson, Richard Houlston, Malcolm Dunlop and colleagues report results of a large genome-wide association study of colorectal cancer. They identify four new risk loci and suggest that many more loci of ...
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Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
Stuart Ralston and colleagues report results of a genome-wide association study for Paget's disease of bone. Their work identifies common variants at three loci associated with risk of this disease.
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Polyposis Syndromes and Colorectal Cancer Predisposition
Colorectal polyps are common, affecting 25% of the population by age 75 years. However, the presence of multiple polyps, particularly in association with a personal or family history of colorectal cancer, shou...
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New insights into the aetiology of colorectal cancer from genome-wide association studies
Recent studies have identified common genetic variants that contribute to colorectal cancer aetiology, providing new insight into the genetic architecture of the disease. Associations identified so far suggest...
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A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk...
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we ...
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we geno...
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Open AccessChromatin structure and evolution in the human genome
Evolutionary rates are not constant across the human genome but genes in close proximity have been shown to experience similar levels of divergence and selection. The higher-order organisation of chromosomes h...
