32 Result(s)

Article

Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes

We evaluated the prognostic relevance of several clinical and laboratory parameters in 226 Mayo Clinic patients with chronic myelomonocytic leukemia (CMML): 152 (67%) males and median age 71 years. At a median...

M M Patnaik, E Padron, R R LaBorde, T L Lasho, C M Finke, C A Hanson… in Leukemia (2013)

Article

Impact of lymphocyte and monocyte recovery on the outcomes of allogeneic hematopoietic SCT with fludarabine and melphalan conditioning

We have recently shown that lymphocyte and monocyte recovery by day +100 are associated with survival post myeloablative allogeneic hematopoietic transplant for acute leukemia. We hypothesized that lymphocyte ...

L J DeCook, M Thoma, T Huneke, N D Johnson, R A Wiegand… in Bone Marrow Transplantation (2013)

Article

Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic Study of 277 patients

Unlike the case with acute myeloid leukemia, there is limited information on the prognostic impact of isocitrate dehydrogenase (IDH) mutations in myelodysplastic syndromes (MDS). In the current study of 277 patie...

M M Patnaik, C A Hanson, J M Hodnefield, T L Lasho, C M Finke, R A Knudson… in Leukemia (2012)

Article

Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5, is prognostically worse than an otherwise complex karyotype

Monosomal karyotype (MK) refers to the presence of two or more distinct autosomal monosomies or a single monosomy associated with a structural abnormality. In acute myeloid leukemia, MK has been shown to be pr...

M M Patnaik, C A Hanson, J M Hodnefield, R Knudson, D L Van Dyke, A Tefferi in Leukemia (2011)

Article

Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q)

A Pardanani, M M Patnaik, T L Lasho, M Mai, R A Knudson, C Finke… in Leukemia (2010)

Article

MPL mutation effect on JAK2 46/1 haplotype frequency in JAK2V617F-negative myeloproliferative neoplasms

M M Patnaik, T L Lasho, C M Finke, N Gangat, D Caramazza, S Siragusa… in Leukemia (2010)

Article

JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival

A common JAK2 germline haplotype (46/1) has been associated with JAK2V617F (VF)-positive myeloproliferative neoplasms. The rs12343867 SNP (C/T) tags this haplotype. A total of 130 patients (77 VF-positive) with p...

A Tefferi, T L Lasho, M M Patnaik, C M Finke, K Hussein, W J Hogan, M A Elliott… in Leukemia (2010)

Article

Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML

A Tefferi, K-H Lim, O Abdel-Wahab, T L Lasho, J Patel, M M Patnaik, C A Hanson… in Leukemia (2009)

Article

The complete evaluation of erythrocytosis: congenital and acquired

The approach to a patient with erythrocytosis is greatly simplified by assessing the clonality of the process upfront. In this regard, there has been a dramatic shift toward genetic testing and away from tradi...

M M Patnaik, A Tefferi in Leukemia (2009)

Article

Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction

Veno-occlusive disease is among the most serious complications following hematopoietic stem cell transplantation. While hepatic veno-occlusive disease occurs more commonly, the pulmonary variant remains quite ...

M C Bunte, M M Patnaik, M R Pritzker, L J Burns in Bone Marrow Transplantation (2008)