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  1. No Access

    Article

    Mesenchymal Stem Cells Cultured in 3D System Inhibit Non-Small Cell Lung Cancer Cells through p38 MAPK and CXCR4/AKT Pathways by IL-24 Regulating

    Non-small cell lung cancer (NSCLC) is prevalent worldwide and has a high mortality rate. Even if mesenchymal stem cells (MSCs) are suggested as cancer treatment, the studies of their effects on NSCLC cells con...

    F. Suo, M. Pan, Y. Li, Q. Yan, H. Hu, L. Hou in Molecular Biology (2021)

  2. No Access

    Article

    shRNA-Mediated Suppression of γ-Synuclein Leading to Downregulation of p38/ERK/JNK Phosphorylation and Cell Cycle Arrest in Endometrial Cancer Cells

    In this study, we explored the effects of treating human endometrial cancer cells with γ-synuclein-specific short hairpin RNA (shRNA) and elucidated the associated mechanisms in vitro and in vivo through the p...

    D. Sun, W.-Y. Li, S.-H. Chen, Z.-F. Zhi, H.-S. Lin, J.-T. Fan… in Molecular Biology (2020)

  3. No Access

    Article

    Effects of SGI-1027 on Formation and Elimination of PrPSc in Prion-Infected Cells

    Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrPSc in prion-infected cells. Herein, we confirm the elimination of PrPSc

    J. J. Li, C. S. Ryou, D.-H. Kim in Molecular Biology (2020)

  4. No Access

    Article

    The pH-Sensitive Potassium Channel TASK-1 Is a Chemosensor for Central Respiratory Regulation in Rats

    TWIK-related acid-sensitive potassium channel-1 (TASK-1) is a “leak” potassium channel sensitive to extracellular protons. It contributes to setting the resting potential in mammalian neurons. TASK-1 channels ...

    Q. Q. Li, K. X. Wan, M. S. Xu, L. M. Wang, Y. Y. Zhang, C. T. Wang… in Molecular Biology (2020)

  5. No Access

    Article

    PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study

    PARP10 is an intracellular mono-ADP ribosyltransferase and recent reports suggest that it regulates proliferation of some cell types. However, its effect on the proliferation of colorectal carcinoma cells has ...

    C. F. Wu, M. **ao, Y. L. Wang, M. D. Threadgill, M. Li, Y. Tang… in Molecular Biology (2020)

  6. No Access

    Article

    Regulation of m6A RNA Methylation and Its Effect on Myogenic Differentiation in Murine Myoblasts

    N6-methyladenosine (m6A) has been identified as a conserved epitranscriptomic modification of eukaryotic mRNAs, and plays important biological roles in the regulation of cellular metabolic processes. However, its...

    J. N. Chen, Y. Chen, Y. Y. Wei, M. A. Raza, Q. Zou, X. Y. **, L. Zhu… in Molecular Biology (2019)

  7. No Access

    Article

    Teleost Type 2 Interleukin-1 Receptor (IL-1R2) from the Spotted Halibut (Verasper variegatus): 3D Structure and a Role in Immune Response

    The type 2 interleukin-1 receptor (IL-1R2) is one of natural IL-1β singling inhibitors in mammals. We cloned and sequenced the IL-1R2 gene in V. variegatus (VvIL-1R2). The phylogenetic analysis showed that the mo...

    Z. Li, X. M. Liu, A. Y. Li, X. X. Du, X. B. Wang, J. X. Liu… in Molecular Biology (2019)

  8. No Access

    Article

    MiR-222-3p Regulates the Proliferation and Differentiation of C2C12 Myoblasts by Targeting BTG2

    MiR-222-3p has been implicated in tumor cell proliferation and has an important role in the differentiation and maturation of myogenic cells. However, its role in skeletal myoblast proliferation is still uncle...

    D. L. Yang, M. L. Gan, Y. Tan, G. H. Ge, Q. Li, Y. Z. Jiang… in Molecular Biology (2019)

  9. No Access

    Article

    An RNA Scoring Function for Tertiary Structure Prediction Based on Multi-Layer Neural Networks

    A good scoring function is necessary for ab inito prediction of RNA tertiary structures. In this study, we explored the power of a machine learning based approach as a scoring function. Compared with the tradi...

    Y. Z. Wang, J. Li, S. Zhang, B. Huang, G. Yao, J. Zhang in Molecular Biology (2019)

  10. No Access

    Article

    Identification of Two GLOBOSA-Like MADS-Box Genes in Tea Plant (Camellia sinensis [L.] O. Kuntze)

    Tea plant (Camellia sinensis [L.] O. Kuntze) is a woody crop of high economic importance worldwide; however, information on the molecular mechanisms underlying the regulation of flower development in this species...

    K. Zhou, Q.-X. Cao, C.-M. **, Y.-Y. Niu, G.-L. Li, J.-J. Zhang in Molecular Biology (2019)

  11. No Access

    Article

    De novo Assembly and Analysis of Sumac (Toxicodendron vernicifluum (Stokes) F.A. Barkley) Transcriptomes Provides Insights into the Biosynthesis of Urushiol

    Sumac is universally known for its abundance of raw lacquer. Toxicodendron vernicifluum (Stokes) F.A. Barkley is one of the widely distributed native sumac cultivars. To accelerate sumac breeding for more prolifi...

    G.-Q. Bai, Y. Jia, W.-M. Li, H. Chen, B. Li, S.-F. Li in Molecular Biology (2018)

  12. No Access

    Article

    Transgenic Expression of chit42 gene from Metarhiziumanisopliae in Trichoderma harzianum Enhances Antagonistic Activity against Botrytis cinerea

    Сhitinases expressed by some beneficial fungi are crucial for the biocontrol of phytopathogens. The activity of chitinolytic strains of Trichoderma sp. may be enhanced by increasing the expression of chitinases. ...

    H. **a, Y. Y. Li, Z. C. Liu, Y. Q. Li, J. Chen in Molecular Biology (2018)

  13. No Access

    Article

    SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms

    The assembly of LIM-homeodomain (LIM-HD) transcriptional complex plays important roles in early neuronal development. The stability of LIM-HD is controlled by single-strand binding protein 3 (SSBP3) via a casc...

    Z. Yin, K. Zhang, X. Peng, Z. Jiang, W. Yuan, Y. Wang, Y. Li, X. Ye… in Molecular Biology (2018)

  14. No Access

    Article

    Development and Optimization of Therapeutic Analogues of Anti-TNFα Antibody Infliximab

    Previously, we have reported the crystal structures of Fab fragment of Infliximab in complex with TNFα. The structurally identified epitope on TNFα revealed the mechanism of TNFα inhibition by partially overla...

    X.-J. Yu, Y.-F. Shen, J. Dong, T. Li, C. Wang, Y.-J. Zhang, L.-F. Wang… in Molecular Biology (2018)

  15. No Access

    Article

    The Rice OsDUF810 Family: OsDUF810.7 May be Involved in the Tolerance to Salt and Drought

    With the advance of sequencing technology, the number of sequenced plant genomes has been rapidly increasing. However, understanding of the gene function in these sequenced genomes lags far behind; as a result...

    L.-H. Li, M.-M. Lv, X. Li, T.-Z. Ye, X. He, S.-H. Rong, Y.-L. Dong… in Molecular Biology (2018)

  16. Article

    Erratum to: “Amphioxus ortholog of ecsit, an evolutionarily conserved adaptor in the toll and BMP signaling pathways”

    The name of the first author should read Y. S. Lin.

    Y. S. Lin, W. Zhang, J. W. Li, H. W. Zhang, D. Y. Chen in Molecular Biology (2017)

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  17. No Access

    Article

    High-content siRNA screen of the kinome identifies kinases involved in Git2-induced mesenchymal-epithelial transition

    Epithelial-mesenchymal transition (EMT) and its reverse process mesenchymal-epithelial transition (MET) programs are involced in the metastatic process. More and more evidence confirms that EMT is vital for th...

    M. G. Cao, J. Xu, Q. F. Yang, Z. P. Guo, K. B. Zhang, X.-B. Li… in Molecular Biology (2017)

  18. No Access

    Article

    Fibroblast growth factor receptor 1 propagates estrogen and fluid shear stress driven proliferation and differentiation response in MC3T3-E1 cells

    Fluid shear stress (FSS) and estrogen exposure positively regulate bone metabolism. Fibroblast growth factor receptor 1 (FGFR1) plays a vital role in FSS-induced osteogenesis. An in vitro experiment with MC3T3...

    J. Y. Li, S. G. Liu, G. N. **ao, M. Y. Mao, X. W. Zhang, H. Q. Sun in Molecular Biology (2017)

  19. No Access

    Article

    Amphioxus ortholog of ECSIT, an evolutionarily conserved adaptor in the toll and BMP signaling pathways

    In vertebrates, evolutionarily conserved signaling intermediate in the Toll pathway (ECSIT) interacts with the TNF-receptor associated factor 6 (TRAF6) to regulate the processing of MEKK1, activate NF-κB, and ...

    Y. H. Lin, W. Zhang, J. W. Li, H. W. Zhang, D. Y. Chen in Molecular Biology (2017)

  20. Article

    Erratum to: “Overexpression, Homology Modeling and Coenzyme Docking Studies of the Cytochrome P450nor2 from Cylindrocarpon tonkinense” [Molecular Biology 50, 320 (2016)]

    N. Li, Y. Z. Zhang, D. D. Li, Y. H. Niu, J. Liu, S. X. Li, Y. Z. Yuan… in Molecular Biology (2016)

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