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Article
Investigations of Water Flow Behaviors Induced by Local Temperature Variations through a Single Rough Fracture for the Enhanced Geothermal Systems
In recent years, Enhanced Geothermal System (EGS) technologies have been applied to the geothermal resources production in the Hot Dry Rock (HDR). The core of EGS technologies is to adopt hydraulic fracturing ...
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Article
UCTT: universal and low-cost adversarial example generation for tendency classification
The adversary makes malicious samples capable of triggering erroneous judgments in deep learning models by introducing imperceptible perturbations to the original benign texts. These malicious samples are refe...
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Article
Open AccessTranscriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintain...
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Article
Open AccessProteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngiomas (ACPs) are rare benign epithelial tumours with high recurrence and poor prognosis. Biological differences between recurrent and primary ACPs that may be associated with dise...
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Article
Open AccessThiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore, the effects and mechanisms of microgravity on cardiac morpholo...
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Article
Open AccessCold-induced FOXO1 nuclear transport aids cold survival and tissue storage
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation. Here, by surveying cold-altered chromatin a...
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Article
Toxic Effects of Atrazine on Liver and Underlying Mechanism: A Review
Atrazine (ATR) is one kind of herbicide, which is widely used for weeding of dry crops such as corn, sorghum, and fruit trees. Due to its long half-life in soil and refractory degradation in water, it is easy ...
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Article
Hop** frustration-induced flat band and strange metallicity in a kagome metal
The introduction of localized electronic states into a metal can alter its physical properties, for example enabling exotic metal physics including heavy fermion and strange metal behaviour. A common source of...
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Article
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells
Dysregulation of deubiquitination contributes to various diseases, including cancer, and aberrant expression of deubiquitinating enzymes is involved in carcinoma progression. As a member of the ovarian tumor (...
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Article
The Associations of Urinary DEHP Metabolites in Pregnant Women with Serum Thyroid Hormone and Thyroid-Related Genes in Neonatal Umbilical Cord Blood in Jilin, China
Di-(2-ethylhexyl) phthalate (DEHP) is a widespread environmental endocrine disruptor, while maternal DEHP exposure may affect the thyroid function of newborns. The purpose of this study was to assess influenti...
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Article
Open AccessSNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese
Drug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese.
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Article
Application of superconducting cavity tuner in dark photon dark matter search
In order to precisely control the resonant frequency of RF superconducting cavity to detect dark photon dark matter, and to be able to tune within a certain frequency range, it is necessary to design a low-tem...
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Article
Open AccessSwimming exercise reverses transcriptomic changes in aging mouse lens
The benefits of physical activity for the overall well-being of elderly individuals are well-established, the precise mechanisms through which exercise improves pathological changes in the aging lens have yet ...
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Article
Direct oral anticoagulants (DOACs) versus low-molecular-weight heparin (LMWH) for extended thromboprophylaxis following major abdominal/pelvic cancer-related surgery: a systematic review and meta-analysis
The use of direct oral anticoagulants (DOACs) as an alternative to low-molecular-weight heparin (LMWH) for extended thromboprophylaxis of abdominal/pelvic cancer-related postoperative thromboembolism (VTE) is ...
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Article
Novel Techniques and Models for Studying the Role of the Gut Microbiota in Drug Metabolism
The gut microbiota, known as the second human genome, plays a vital role in modulating drug metabolism, significantly impacting therapeutic outcomes and adverse effects. Emerging research has elucidated that t...
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Article
Stock portfolio optimization based on factor analysis and second-order memetic differential evolution algorithm
Portfolio optimization will apply the concept of diversification across asset classes, which means investing in a wide variety of asset types and classes for a risk-mitigation strategy. Portfolio optimization ...
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Article
Open AccessExpert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However...
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Article
A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation
Human induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in ...
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Article
Open AccessDisrupted Tuzzerella abundance and impaired l-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis
The microbial community plays a crucial role in the pathological microenvironment. However, the structure of the microbial community within endometriotic lesions and its impact on the microenvironment is still...
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Article
Open AccessEfficacy and safety of direct oral anticoagulants versus low-molecular-weight heparin for thromboprophylaxis after cancer surgery: a systematic review and meta-analysis
Direct oral anticoagulants (DOACs) used as an alternative to low-molecular-weight heparin (LMWH) for thromboprophylaxis after cancer surgery for venous thromboembolic events (VTE) remains unclear. This study a...
