228 Result(s)

Article

A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity

Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. We evaluated the efficacy and safety of 24-week treatment of mazdutide up to 6 mg in Chinese overweight adults or ...

Linong Ji, Hongwei Jiang, Zhifeng Cheng, Wei Qiu, Lin Liao… in Nature Communications (2023)

Article

A non-invasive mouse model that recapitulates disuse-induced muscle atrophy in immobilized patients

Disuse muscle atrophy occurs consequent to prolonged limb immobility or bed rest, which represents an unmet medical need. As existing animal models of limb immobilization often cause skin erosion, edema, and o...

Kun-Chang Wu, Hsiang-Wen Lin, Po-Chen Chu, Chia-Ing Li… in Scientific Reports (2023)

Article

YFDM: YOLO for detecting Morse code

With the increasing complexity of the shortwave communication environment, the efficiency and accuracy of the manual detection of Morse code no longer meet actual needs. Therefore, this paper proposes a Morse ...

Zhenhua Wei, Zijun Li, Siming Han in Scientific Reports (2023)

Article

Wide-temperature-range thermoelectric n-type Mg₃(Sb,Bi)₂ with high average and peak zT values

Mg₃(Sb,Bi)₂ is a promising thermoelectric material suited for electronic cooling, but there is still room to optimize its low-temperature performance. This work realizes >200% enhancement in room-temperature zT b...

**g-Wei Li, Zhijia Han, **cheng Yu, Hua-Lu Zhuang, Haihua Hu… in Nature Communications (2023)

Article

Pre-earthquake anomaly extraction from borehole strain data based on machine learning

Borehole strain monitoring plays a critical role in earthquake precursor research. With the accumulation of observation data, traditional data processing methods struggle to handle the challenges of big data. ...

Chengquan Chi, Chenyang Li, Ying Han, Zining Yu, **ang Li… in Scientific Reports (2023)

Article

Efficacy and safety of eltrombopag in Chinese patients with refractory or relapsed severe aplastic anemia

For patients with severe aplastic anemia (SAA) in China who have had an insufficient response to the first-line treatment with hematopoietic stem cell transplantation or immunosuppressive therapy, there is no ...

Hong Chang, Guangsheng He, Rong Fu, Fei Li, Bing Han, Tao Li, Lei Liu… in Scientific Reports (2023)

Article

A carbon-nitrogen negative feedback loop underlies the repeated evolution of cnidarian–Symbiodiniaceae symbioses

Symbiotic associations with Symbiodiniaceae have evolved independently across a diverse range of cnidarian taxa including reef-building corals, sea anemones, and jellyfish, yet the molecular mechanisms underly...

Guoxin Cui, Jianing Mi, Alessandro Moret, Jessica Menzies… in Nature Communications (2023)

Article

Photocatalytic CO₂ reduction to syngas using metallosalen covalent organic frameworks

Metallosalen-covalent organic frameworks have recently gained attention in photocatalysis. However, their use in CO₂ photoreduction is yet to be reported. Moreover, facile preparation of metallosalen-covalent org...

Wei Zhou, **ao Wang, Wenling Zhao, Naijia Lu, Die Cong, Zhen Li… in Nature Communications (2023)

Article

Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep

Copy number variation (CNV) is a genetic structural polymorphism important for phenotypic diversity and important economic traits of livestock breeds, and it plays an important role in the desired genetic vari...

Dehong Tian, De Sun, Qianben Ren, Pei Zhang, Zian Zhang, Wenkui Zhang… in Scientific Reports (2023)

Article

Dual hypoxia-responsive supramolecular complex for cancer target therapy

The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable therapeutic option. However, ...

Jian-Shuang Guo, Juan-Juan Li, Ze-Han Wang, Yang Liu, Yu-**n Yue… in Nature Communications (2023)

Article

Simulating Chern insulators on a superconducting quantum processor

The quantum Hall effect, fundamental in modern condensed matter physics, continuously inspires new theories and predicts emergent phases of matter. Here we experimentally demonstrate three types of Chern insul...

Zhong-Cheng **ang, Kaixuan Huang, Yu-Ran Zhang, Tao Liu… in Nature Communications (2023)

Article

Author Correction: A photochemical-responsive nanoparticle boosts doxorubicin uptake to suppress breast cancer cell proliferation by apoptosis

Ying Zhang, Kaiting Li, **aoyu Han, Qing Chen, Lan Shao, Dingqun Bai in Scientific Reports (2023)

Article

Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning

The patterns of communication among different chondrocyte subtypes in human cartilage degeneration and regeneration help us understand the microenvironment of osteoarthritis and optimize cell-targeted therapie...

Jiajian Wang, Caihong Liu, Litao Yang, Huixiong Chen, Mingqi Zheng… in Scientific Reports (2023)

Article

QTG-Miner aids rapid dissection of the genetic base of tassel branch number in maize

Genetic dissection of agronomic traits is important for crop improvement and global food security. Phenotypic variation of tassel branch number (TBN), a major breeding target, is controlled by many quantitativ...

** Wang, Juan Li, Linqian Han, Chengyong Liang, Jiaxin Li… in Nature Communications (2023)

Article

Biology-guided deep learning predicts prognosis and cancer immunotherapy response

Substantial progress has been made in using deep learning for cancer detection and diagnosis in medical images. Yet, there is limited success on prediction of treatment response and outcomes, which has importa...

Yuming Jiang, Zhicheng Zhang, Wei Wang, Weicai Huang, Chuanli Chen… in Nature Communications (2023)

Article

A transfer learning-based multimodal neural network combining metadata and multiple medical images for glaucoma type diagnosis

Glaucoma is an acquired optic neuropathy, which can lead to irreversible vision loss. Deep learning(DL), especially convolutional neural networks(CNN), has achieved considerable success in the field of medical...

Yi Li, Yujie Han, Zihan Li, Yi Zhong, Zhifen Guo in Scientific Reports (2023)

Article

A novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytes

Choroidal neovascularization (CNV) occurs in neovascular age-related macular degeneration (AMD) and often leads to permanent visual impairment. Intravitreal injection of anti-vascular endothelial growth factor...

Yaming Shen, Miao Xu, Ling Ren, **umiao Li, **aoyan Han, **n Cao… in Scientific Reports (2023)

Article

A chemiresistive-potentiometric multivariate sensor for discriminative gas detection

Highly efficient gas sensors able to detect and identify hazardous gases are crucial for numerous applications. Array of conventional single-output sensors is currently limited by problems including drift, lar...

Hong Zhang, Zuobin Zhang, Zhou Li, Hongjie Han, Weiguo Song… in Nature Communications (2023)

Article

Machine learning-assisted crystal engineering of a zeolite

It is shown that Machine Learning (ML) algorithms can usefully capture the effect of crystallization composition and conditions (inputs) on key microstructural characteristics (outputs) of faujasite type zeoli...

**nyu Li, He Han, Nikolaos Evangelou, Noah J. Wichrowski, Peng Lu… in Nature Communications (2023)

Article

Field-free spin-orbit torque switching via out-of-plane spin-polarization induced by an antiferromagnetic insulator/heavy metal interface

Manipulating spin polarization orientation is challenging but crucial for field-free spintronic devices. Although such manipulation has been demonstrated in a limited number of antiferromagnetic metal-based sy...

Mengxi Wang, Jun Zhou, **aoguang Xu, Tanzhao Zhang, Zhiqiang Zhu… in Nature Communications (2023)