236 Result(s)

Article

Integration of transcriptomics and metabolomics reveals a novel gene signature guided by FN1 associated with immune response in oral squamous cell carcinoma tumorigenesis

Oral squamous cell carcinomas (OSCCs) are primary head and neck malignant tumours with a high incidence and mortality. However, the molecular mechanisms involved in OSCC tumorigenesis are not fully understood.

Yongchun Peng, Danhui Yin, **aoxuan Li… in Journal of Cancer Research and Clinical On… (2023)

Article

Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial–mesenchymal transition through the Wnt/β-catenin signaling pathway

Colorectal cancer (CRC) is the leading cause of cancer deaths worldwide, wherein distant metastasis is the main reason for death. The non-psychoactive phytocannabinoid cannabidiol (CBD) effectively induces the...

PanFeng Feng, LongXun Zhu, **g Jie… in Journal of Cancer Research and Clinical On… (2023)

Article

Histomorphological and molecular genetic characterization of different intratumoral regions and matched metastatic lymph nodes of colorectal cancer with heterogenous mismatch repair protein expression

To better understand the clinicopathological characteristics and molecular alterations in different intratumoral components of colorectal cancer (CRC) with heterogeneity of mismatch repair (MMR) protein expres...

**g Zhang, **n Zhang, Qian Wang, Yu-yin Xu… in Journal of Cancer Research and Clinical On… (2023)

Article

m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma

N6 methyladenosine (m6A) RNA methylation regulators play a key role in the occurrence and development of many tumors. However, the function of N6 methyladenosine (m6A) RNA methylation regulators in pancreatic ...

Tao Zhang, ** Sheng, Yuting Jiang in Journal of Cancer Research and Clinical Oncology (2023)

Article

Vessels that encapsulate tumor clusters (VETC) pattern predicts the efficacy of adjuvant TACE in hepatocellular carcinoma

Postoperative adjuvant trans-catheter arterial chemoembolization (TACE) is regarded as a common strategy for hepatocellular carcinoma (HCC) patients at a high risk of recurrence. However, there are currently n...

Jia-hong Wang, **ao-shan Li, Hong-sheng Tang… in Journal of Cancer Research and Clinical On… (2023)

Article

Hydrogen sulfide suppresses H₂O₂-induced proliferation and migration of HepG2 cells through Wnt/β-catenin signaling pathway

Both H₂S and H₂O₂ affect many cellular events, such as cell differentiation, cell proliferation and cell death. However, there is some controversy about the roles of H₂S and H₂O_2, since the detailed mechanisms th...

Hongzhi Zhao, Liang Zhao, Lin Wu, Sheng Hu, Yangmei Huang, Wei Zhao in Medical Oncology (2023)

Article

HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m⁶A-dependent stabilization of KDM4B mRNA

Hypoxia inducible factor 1α (HIF1α) is abnormally overexpressed in t(8;21) acute myeloid leukemia (AML) and functions as an oncogene through transactivating DNA methyltransferase 3 alpha leading to DNA hyperme...

Yang-Liu Shao, Yu-Qing Li, Meng-Yue Li, Li-Li Wang, Hui-Sheng Zhou… in Leukemia (2023)

Article

Is adjacent lobe invasion an T category upgrade factor for resected non-small cell lung cancer ≤ 5 cm?

Controversy exists with regard to the T category of non-small cell lung cancer (NSCLC) with adjacent lobe invasion (ALI), and dispute arises on assigning this subset into T2 or T3 category. We evaluated the ef...

**g-Sheng Cai, Qian-Yi Lin, **ao-Meng Dou in Journal of Cancer Research and Clinical On… (2023)

Article

Upregulation of TUBG1 expression promotes hepatocellular carcinoma development

Tubulin γ-1 (TUBG1) is a highly conserved component of the centrosome and its deregulation is involved in the development of several types of cancer. However, the role of TUBG1 in hepatocellular carcinoma (HCC) r...

Zi-jian Wang, Zhi-zheng Dai, Mei-zhen Hu, Jun-nan Liu, Hang Liang… in Medical Oncology (2023)

Article

FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes

In cancer cells, multiple oncogenes and tumor suppressors control glycolysis to sustain rapid proliferation. The ETS-related transcription factor Fli1 plays a critical role in the induction and progression of ...

Danmei Sheng, Beiling Chen, Chunlin Wang, **ao **ao, Anling Hu… in Medical Oncology (2022)

Article

A prognostic survival nomogram for persons with extra-nodal natural killer-/T-cell lymphoma

Hua Wang, Bi-bo Fu, Zhi-jun Wuxiao, Ya-jun Li, Li Huang, Jie Ma, Zhi-min Zhai… in Leukemia (2022)

Article

Hepatitis B surface antigen positivity is associated with progression of disease within 24 months in follicular lymphoma

Studies have reported a positive association between hepatitis B surface antigen (HBsAg)-positive hepatitis B virus (HBV) infection and follicular lymphoma (FL). Nevertheless, clinical information concerning c...

Chieh-Lung Cheng, Wei-Quan Fang, Yu-Jen Lin… in Journal of Cancer Research and Clinical On… (2022)

Article

ERBB2 S310F mutation independently activates PI3K/AKT and MAPK pathways through homodimers to contribute gallbladder carcinoma growth

Genomic instability and mutability are a prominent character of tumor. The whole-exosome sequence reveals that ERBB2 mutations are the representative mutations of gallbladder carcinoma, which takes potential t...

Kun Fan, Jiwen Wang, Sheng Shen, **aojian Ni, Zijun Gong, Bohao Zheng… in Medical Oncology (2022)

Article

Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism

Inflammatory microenvironment is known to accelerate the progression of malignant tumors. We investigated the possible anti-inflammatory effect of nicaraven on slowing tumor growth. Tumor-bearing mice randomly...

Lina Abdelghany, Xu Zhang, Tsuyoshi Kawabata, Shinji Goto… in Medical Oncology (2021)

Article

Expression profile of PU.1 in CD4⁺T cells from patients with systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complex genetic predisposing factors involved. PU.1 is an important member of the ETS transcription factors family which has diverse ...

Nan **ang, Xuan Fang, **ao-Ge Sun, Ying-Bo Zhou… in Clinical and Experimental Medicine (2021)

Article

Real-world analysis of clinicopathological characteristics, survival rates, and prognostic factors in patients with melanoma brain metastases in China

We aimed to establish the clinicopathological characteristics and prognostic factors of patients with melanoma brain metastases (MBM) in the East Asian population.

Yang Wang, Bin Lian, Lu Si, ZhiHong Chi… in Journal of Cancer Research and Clinical On… (2021)