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Article
Failure of radioiodine treatment in Graves’ disease intentionally caused by a patient: Suspected Munchausen syndrome
We experienced a case with Graves’ disease in which radioiodine treatment failed probably because of intentional spitting out of capsules of radioactive iodide. Chemical analysis of the substances collected fr...
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Article
Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy
We attempted to determine whether the combined regimen of radioimmunotherapy (RIT) and antiangiogenic therapy would favorably affect the survival of animals bearing liver metastases of colon cancer cells. Dail...
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Article
Multifactorial analysis on the short-term side effects occurring within 96 hour after radioiodine-131 therapy for differentiated thyroid carcinoma
This study was performed to clarify factors that might influence short-term side effects occurring within 96 hours after administration of131I for patients with thyroid carcinoma.Methods: In 71 patients with diff...
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Article
Single dose planning for radioiodine-131 therapy of Graves’ disease
Patients with Graves’ disease were studied one year after radioiodine-131 therapy to assess the relationship between the effectiveness of the therapy and the radioiodine doses used.Methods: Patients were classifi...
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Article
Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function
Hypoxia reduces the uptake of technetium-99m sestamibi (MIBI) in human cancer cell lines. In the current investigation, we attempted to identify the relationship between hypoxia-induced alteration of 99mTc-MIBI a...
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Article
Preliminary evaluation of image reconstruction by ordered-subset expectation maximization in thallium-201 lung scintigraphy
Objectives: We observed whether clearer tumor delineation and greater tumor to non-tumor (T/N) count ratios could be obtained using an iterative ordered-subsets expectation maximization (OSEM) al...
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Article
Local delivery of 131I-MIBG to treat peritoneal neuroblastoma
Internal radiotherapy involving systemic administration of iodine-131 metaiodobenzylguanidine (131I-MIBG) in neural crest tumours such as neuroblastoma has shown considerable success. Although peritoneal seeding ...
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Article
Feasibility of 186Re-radioimmunotherapy for treatment in an adjuvant setting of colon cancer
186Re displays abundant intermediate energy β emission, and possesses an appropriate physical half-life of 3.7 days. We compared the efficacy of radioimmunotherapy (RIT) with an anti-colorectal cancer monoclonal...
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Article
Benefits of combined radioimmunotherapy and anti-angiogenic therapy in a liver metastasis model of human colon cancer cells
The combined use of anti-angiogenic therapy (AT) and radioimmunotherapy (RIT) may improve the therapeutic outcome in patients with cancer lesions. This hypothesis is based on the ability of AT to suppress tum...
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Article
Hypoxia-induced alteration of tracer accumulation in cultured cancer cells and xenografts in mice: implications for pre-therapeutic prediction of treatment outcomes with 99mTc-sestamibi, 201Tl chloride and 99mTc-HL91
Weak visualization of tumours in pre-therapeutic scintigrams with technetium-99m sestamibi (MIBI) is likely a predictive sign of unfavourable tumour response to radiotherapy and chemotherapy. However, factors...
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Article
Radionuclide cisternography in intracranial hypotension syndrome
A 44-year-old male patient complaining of severe headache right after twisting his body during aerobic exercises in a swimming pool underwent In-111 DTPA radionuclide cisternography. Leakage of cerebrospinal f...
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Article
Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts
Angiogenesis is critical to the growth and metastatic process of malignant tumors. An endogenous estrogen metabolite, 2-methoxyestradiol (2-ME), displays anti-angiogenic and anti-tumorigenic effects. The purp...
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Article
A case of double cancers with myocardial metastasis mimicking acute myocardial infarction both on an electrocardiogram and on Tc-99m-MIBI myocardial SPECT
We report a rare case of double cancers with myocardial metastasis presenting acute myocardial infarction (AMI)-like findings both on an electrocardiogram (ECG) and on Tc-99m-MIBI myocardial SPECT. The ECG sho...
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Article
Experimental radioimmunotherapy with186Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with131I-counterpart
A murine IgG1 against aMr 45 kD tumor-associated glycoprotein in human colorectal cancer, A7, was radiolabeled with186Re by a chelating method with a mercaptoacetyltriglycine (MAG3). Its specific activity was 119...
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Article
Improved response of colon cancer xenografts to radioimmunotherapy with pentoxifylline treatment
A methylxanthine, pentoxifylline (PTX), has the potential to improve tumour microcirculation and oxygenation in vivo. We aimed to determine whether this agent would enhance the response of tumours to experime...
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Article
Sentinel lymph node biopsy in breast cancer using blue dye with or without isotope localization
The purpose of this study was to determine the feasibility of sentinel lymph node (SLN) biopsy using blue dye with or without isotope localization to predict the presence of axillary and internal mammary lymph...
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Article
Increased uptake of99mTc-HL91 in tumor cells exposed to X-ray radiation
99mTc-HL91, a hypoxic marker, may be a predictor of tumor response to radiotherapy and an indicator of tumor oxygenation in the course of treatment. In this study, serial changes in99mTc-HL91 upt...
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Article
Dye- and gamma probe-guided sentinel lymph node biopsy in breast cancer patients: using patent blue dye and technetium-99m-labeled human serum albumin
Sentinel lymph node (SLN) biopsy is a promising method for the diagnosis of the axillary nodal status. We examined the availability of the SLN biopsy using two map** procedures: the dye- and gamma probe-guid...
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Article
Efficacy, toxicity and mode of interaction of combination radioimmunotherapy with 5-fluorouracil in colon cancer xenografts
Purpose:The feasibility of radioimmunotherapy (RAIT) combined with 5-fluorouracil (5-FU) was examined in colon cancer xenografts. The mode of interaction of the two treatments was also investigated. Methods : Mi...
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Article
Staging efficacy of breast cancer with sentinel lymphadenectomy
Seventy‐two patients underwent dye‐guided or dye‐ and gamma probe‐guided sentinel lymphadenectomy (SLND) followed by complete axillary lymph node dissection (ALND). The results of imprint cytology, frozen sect...
