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Open AccessRetinal determination gene networks: from biological functions to therapeutic strategies
The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an important regulatory network in tumorigenesis and progression, as well ...
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Article
Open AccessChromosome-level genome of black cutworm provides novel insights into polyphagy and seasonal migration in insects
The black cutworm, Agrotis ipsilon, is a serious global underground pest. Its distinct phenotypic traits, especially its polyphagy and ability to migrate long distances, contribute to its widening distribution an...
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Open AccessIncreased expression of ECT2 predicts the poor prognosis of breast cancer patients
Breast cancer is the most common malignancy and the second leading cause of cancer-related death in women. Recent studies have indicated that aberrant activation of Rho GTPases relates to the malignant propert...
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Open AccessNote on graph-based BCJ relation for Berends-Giele currents
Graph-based Bern-Carasso-Johansson (BCJ) relation for Berends-Giele currents in bi-adjoint scalar (BS) theory, which is characterized by connected tree graphs, was proposed in an earlier work. In this note, we...
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Open AccessCorrection: DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
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The evolution of China’s regulation of agricultural biotechnology
To ensure safe use of genetically modified organisms (GMOs), since 1993, China has made great efforts to establish and improve the safety regulatory system for GMOs. Here, we summarize and analyze the regulato...
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Open AccessA comparative study of interfacial thermal conductance between metal and semiconductor
To understand and control thermal conductance of interface between metal and semiconductor has now become a crucial task for the thermal design and management of nano-electronic and micro-electronic devices. T...
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Article
Quantum computation using action variables
In 2014, Lloyd and Montangero have made a brief research proposal on universal quantum computation in integrable systems. The main idea is to encode qubits into quantum action variables and build up quantum ga...
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Open AccessCombination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors
Non-inflamed tumors, including immune-excluded and immune-desert tumors, are commonly resistant to anti-PD-1/PD-L1 (α-PD-1/PD-L1) therapy. Our previous study reported the potent antitumor activity of anti-TGF-...
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Open AccessMyeloid-derived suppressor cells: an emerging target for anticancer immunotherapy
The clinical responses observed following treatment with immune checkpoint inhibitors (ICIs) support immunotherapy as a potential anticancer treatment. However, a large proportion of patients cannot benefit fr...
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Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens
(±)-Decumicorine A (1) and (±)-epi-decumicorine A (2), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated protoberberine skeleton, were isolated and purified from the rh...
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Open AccessMetabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity
Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the pathogenesis of aut...
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Biomimetic copper single-atom nanozyme system for self-enhanced nanocatalytic tumor therapy
Single-atom nanozymes (SAZs) with peroxidase (POD)-like activity have good nanocatalytic tumor therapy (NCT) capabilities. However, insufficient hydrogen peroxide (H2O2) and hydrogen ions in the cells limit their...
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Open AccessGenome of the hoverfly Eupeodes corollae provides insights into the evolution of predation and pollination in insects
Hoverflies (Diptera: Syrphidae) including Eupeodes corollae are important insects worldwide that provide dual ecosystem services including pest control and pollination. The larvae are dominant predators of aphids...
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YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer
Y-box binding protein 1 (YB-1) is a well-known oncogene highly expressed in various cancers, including basal-like breast cancer (BLBC). Beyond its role as a transcription factor, YB-1 is newly defined as an ep...
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Development and validation of a CT-based nomogram to predict spread through air space (STAS) in peripheral stage IA lung adenocarcinoma
To develop and validate a simple-to-use nomogram based on preoperative CT to predict spread through air space (STAS) status of stage IA lung adenocarcinoma (ADC).
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Open AccessTumor organoids: applications in cancer modeling and potentials in precision medicine
Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors contribute to treatment failure ...
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Biomass-assisted approach for large-scale construction of multi-functional isolated single-atom site catalysts
In recent years, the isolated single-atom site (ISAS) catalysts have attracted much attention as they are cost-effective, can achieve 100% atom-utilization efficiency, and often display superior catalytic perf...
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Atomically dispersed Ni anchored on polymer-derived mesh-like N-doped carbon nanofibers as an efficient CO2 electrocatalytic reduction catalyst
Efficient electroreduction of CO2 into CO and other chemicals turns greenhouse gases into fuels and value-added chemicals, holding great promise for a closed carbon cycle and the alleviation of climate changes. H...
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Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
The mouse visual system serves as an accessible model to understand mammalian circuit wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from distinct retinal ganglion cell (RG...
