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Article
Cell lineage dynamics in the process leading to intestinal metaplasia
Gene expression in the early stage of the transition to intestinal metaplasia in human gastric mucosa has not been determined. In this study, we investigated the temporal relationship between cell lineage chan...
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Article
Diagnosis of gastric antral vascular ectasia by transnasal flexible spectral imaging color enhancement
The endoscopic appearance of gastric antral vascular ectasia (GAVE) can be easily misinterpreted as inflammatory changes of gastric mucosa. We report on a case of GAVE that had been missed by conventional tran...
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Article
Endoscopic submucosal dissection of esophageal lymphangioma: a case report with a review of the literature
Esophageal lymphangioma is a very rare disease. We report a case of esophageal lymphangioma successfully treated with endoscopic submucosal dissection (ESD), which yielded definitive histological diagnosis and...
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Article
The revised Japanese clinical diagnostic criteria for chronic pancreatitis
In Japan, we are now using the clinical diagnostic criteria for chronic pancreatitis (CP) that were revised in 2001 to add the findings of magnetic resonance cholangiopancreatography to the criteria compiled b...
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Article
Diagnosis of small flat early gastric cancer by flexible spectral imaging color enhancement
Current conventional endoscopy often misses flat early gastric cancers (0–IIb) because they are sometimes invisible. We experienced a case of small flat early gastric cancer that had been missed by normal-cali...
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Article
A case of acute hepatitis C caused by interspousal transmission after 30 years of marriage
We describe a case of interspousal transmission of hepatitis C virus (HCV) infection after 30 years of marriage which was confirmed by gene analysis. A 60-year-old man was referred to our hospital because of s...
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Article
Diagnosis of endoscopic Barrett’s esophagus by transnasal flexible spectral imaging color enhancement
The diagnosis of endoscopic Barrett’s esophagus (BE) has been under discussion for the past decade because palisade vessels may be obscured by inflammation or the location of upper end of gastric fold may be d...
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Article
Autoimmune pancreatitis associated with a large pancreatic pseudocyst that disappeared after corticosteroid therapy: a case report and literature review
A 51-year-old woman was admitted to our department because of upper abdominal pain. The serum IgG4 concentration was elevated, and abdominal computed tomography revealed diffuse enlargement of the pancreas ass...
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Article
Nonsteroidal anti-inflammatory drug-induced small-bowel lesions identified by double-balloon endoscopy: endoscopic features of the lesions and endoscopic treatments for diaphragm disease
Nonsteroidal anti-inflammatory drugs (NSAIDs) occasionally induce small-bowel injury. However, the clinical features have only been partially clarified. The aim of this study was to clarify the clinical featur...
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Article
Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-κB
While cyclooxygenase-2 (COX-2) is not normally expressed by epithelial cells lining the human colon, COX-2 protein is aberrantly overexpressed in premalignant adenomatous polyps and carcinomas of the human col...
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Article
Prevention of gastric cancer: urgent need to implement Helicobacter pylori eradication therapy as a primary preventive measure in Japan
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Article
Differential gene expression between flat adenoma and normal mucosa in the colon in a microarray analysis
Flat adenomas in the colon are associated with a relatively higher potential for malignancy. Distinct genes may be involved in the development of flat adenoma. The aim of this study was to profile gene express...
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Article
Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure
Ghrelin is a body weight-regulating peptide produced and secreted primarily by the gastric mucosa. Helicobacter pylori infection impairs gastric ghrelin production, leading to a lower plasma ghrelin concentration...
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Article
A case report of chronic enterocolic phlebosclerosis; a possible consequence of chronic manifestation of enterocolic phlebitis
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Article
Gastrointestinal stromal tumor in the jejunum: diagnosis and control of bleeding with electrocoagulation by using double-balloon enteroscopy
A 43-year-old man presented with gastrointestinal bleeding. A tumor with central ulceration was observed in the jejunum, with the use of a new enteroscopy system called “double-balloon enteroscopy”. Bleeding a...
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Article
Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa
There have been no detailed reports directly comparing the expression of CDX1 with that of CDX2 in the inflammatory esophageal mucosa and Barrett's epithelium. The present study was designed to examine the ex...
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Article
Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia
The CDX1 and CDX2 genes are intestinal transcription factors that may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. There have been no detailed reports direct...
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Article
Cholangiographic findings of early-stage extrahepatic bile duct carcinoma
To clarify the cholangiographic findings of early-stage (T1, tumor confined to the mucosal or fibromuscular layer) extrahepatic bile duct carcinoma. Methods. Cholangiographic images were retrospectively analyzed...
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Article
Loo** technique for transpapillary selective biopsy of the left hepatic duct
Because biopsy forceps tend to turn towards the right hepatic duct during endoscopic retrograde cholangiopancreatography (ERCP), selective access to the left hepatic duct is difficult. Methods. In this study, we...
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Article
Microwave coagulation therapy for liver cancer: laparoscopic microwave coagulation