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Article
Open AccessRAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair
RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis (TLS) and homologous recombination (HR) repair. However, whether and how the regulatory mechanism of O-linked N-acetylglu...
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Article
Strength Degradation Mechanism of CFRP and Aluminium Alloy Hybrid Bonded-Riveted Joints Under Salt Spray Environment
Hybrid bonded-riveted joint has poor corrosion resistance under salt spray environment, especially for dissimilar materials. The study investigates the strength degradation mechanism of carbon fiber reinforced...
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Article
A guide to cell death pathways
Regulated cell death mediated by dedicated molecular machines, known as programmed cell death, plays important roles in health and disease. Apoptosis, necroptosis and pyroptosis are three such programmed cell ...
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Article
Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy
Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of major genetic variants in the etiology of CP, we conducted exome sequencing on a large-scale cohort with clinical m...
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Article
Study on influence factors and control optimizations of sewage sludge drying and incineration system for energy conservation
Sewage sludge drying and incineration technology has become more and more popular worldwide recent years, while high energy consumption problem is always accused. Taking a large sludge drying and incineration ...
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Article
Open AccessA comparison of clinical features between neurobrucellosis and tuberculous meningitis
This study aims to compare the clinical manifestations, imaging findings, routine tests, biochemistry indicators and cerebrospinal fluid cytology between neurobrucellosis and tuberculous meningitis. The object...
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Article
Open AccessLoss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice
Viral myocarditis, an inflammatory disease of the myocardium, is a significant cause of sudden death in children and young adults. The current coronavirus disease 19 pandemic emphasizes the need to understand ...
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Article
Nitrogen-doped activated carbon derived from biomass waste for effective removal of doxycycline from aqueous solution: characterization and adsorption mechanism
The nitrogen-doped activated carbon (NAC) with high specific area (3140.76 m2·g− 1) derived from pomelo peel was prepared using hydrothermal carbonization, nitrogen do** and KOH activation method for the effect...
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Article
Quick and situ-aware spatiotemporal scheduling for shipbuilding manufacturing
Spatiotemporal scheduling of the block assembly process in shipbuilding is to determine temporal information including a time period when each block is under assembly and spatial information including an assig...
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Article
Open AccessEffect of Infusion Set Replacement Intervals on Central Line-Associated Bloodstream Infection in the Intensive Care Unit: Study Protocol of the INSPIRATION Study
The replacement intervals for infusion sets may differ among healthcare institutions, which may have an impact on the occurrence of central line-associated bloodstream infections (CLABSI). Nevertheless, there ...
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Article
Efficient-Unet: Intelligent identification of abrasive grain on the entire surface of monolayer brazing wheel based on encoder–decoder network
Measuring and extracting abrasive grains on the entire surface of monolayer brazing grinding wheels to analyze the distribution of abrasive grains are of great significance to grinding research and grinding wh...
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Article
The interleukin enhancer binding factor-2 (ILF2) gene in Penaeus japonicus shrimp: cloning, tissue distribution, and antiviral effects
It is reported that ILF2 (interleukin enhancer binding factor 2) is involved in the immune response by regulating the transcription of interleukin 2 (IL2), which may play an important role in host-virus interacti...
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Article
Evaluation of winter-wheat water stress with UAV-based multispectral data and ensemble learning method
Combining multiple features of UAV-based multispectral images with the stacking ensemble model, to improve the feasibility and accuracy of evaluating water stress in winter wheat.
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Article
First-principles study of laser absorption characteristics of five typical explosives
The ultrafast high peak powers of femtosecond laser ablation can be used to safely process explosives by precisely controlling the laser energy and focus. The laser absorption mechanisms and capacities are wav...
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Article
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for a spectrum of progeroid disorders characterized by the accumulation of farnesylated prelam...
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Article
Open AccessMonolithic back-end-of-line integration of phase change materials into foundry-manufactured silicon photonics
Monolithic integration of novel materials without modifying the existing photonic component library is crucial to advancing heterogeneous silicon photonic integrated circuits. Here we show the introduction of ...
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Article
Open AccessCortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex.
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Article
Open AccessDeep learning-based label-free imaging of lymphatics and aqueous veins in the eye using optical coherence tomography
We demonstrate an adaptation of deep learning for label-free imaging of the micro-scale lymphatic vessels and aqueous veins in the eye using optical coherence tomography (OCT). The proposed deep learning-based...
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Article
A non-residue surface modification strategy for active-targeting fluorescent silica nanoparticles to cellular organelles
Silica nanoparticles (SiNPs) with a chemically modified surface typically have a complicated chemical composition, which can significantly differ from their intended design. In this study, we systematically st...
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Article
Open AccessBrain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. However, it is unclear whether the signals of bone cells in response to mechanical stress are...
