2,902 Result(s)
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Jun-**a Wei
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Article
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance
Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive (ER+) breast cancer. However, the efficacy of agents such as tamoxifen (Tam) is often ...
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Open AccessSimultaneous integrated boost intensity-modulated radiotherapy post breast-conserving surgery: clinical efficacy, adverse effects, and cosmetic outcomes in breast cancer patients
Simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) is an innovative technique delivering a higher dose to the tumor bed while irradiating the entire breast. This study aims to assess the...
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Open AccessNotoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...
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Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury
Activation of endogenous neural stem cells (NSC) is one of the most potential measures for neural repair after spinal cord injury. However, methods for regulating neural stem cell behavior are still limited. H...
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Open AccessExploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Existing studies have found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cel...
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Open AccessSearch for long-lived heavy neutrinos in the decays of B mesons produced in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search for long-lived heavy neutrinos (N) in the decays of B mesons produced in proton-proton collisions at ...
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Genotypic richness affects inorganic N uptake and N form preference of a clonal plant via altering soil N pools
Similar to species richness, genotypic richness of plants plays a pivotal role in the structure and function of ecosystems. While the contribution of intraspecific variability to ecosystem function has been we...
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Open AccessPJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance in nasopharyngeal carcinoma remains to be elucida...
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Article
Association Between a Failed Prominence Eruption and the Drainage of Mass from Another Prominence
Sympathetic eruptions of solar prominences have been studied for decades, however, it is usually difficult to identify their causal links. Here, we present two failed prominence eruptions on 26 October 2022 an...
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Open AccessGWAS combined with QTL map** reveals the genetic loci of leaf morphological characters in Nicotiana tabacum
Leaf morphology plays a crucial role in photosynthetic efficiency and yield potential in crops. Cigar tobacco plants, which are derived from common tobacco (Nicotiana tabacum L.), possess special leaf characteris...
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Open AccessSearch for heavy neutral leptons in final states with electrons, muons, and hadronically decaying tau leptons in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search for heavy neutral leptons (HNLs) of Majorana or Dirac type using proton-proton collision data at ...
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Parameter Optimization of Plow Mixer Structure Based on EDEM
Due to the dynamic complexity and diversity of structural parameters, the mixing efficiency improving of plow mixer is a challenge. In this study, the mixing behavior of particles simulated by the discrete ele...
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Analysis of CCND3 mutations in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), accounts for 30–40% of newly diagnosed lymphomas, has an overall cure rate of approximately 60%. Despite previous reports suggesting a negative prognostic association bet...
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Unveiling the Re, Cr, and I diffusion in saturated compacted bentonite using machine-learning methods
The safety assessment of high-level radioactive waste repositories requires a high predictive accuracy for radionuclide diffusion and a comprehensive understanding of the diffusion mechanism. In this study, a ...
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Preparation of bifunctional electrocatalyst by recycling heavy metal ions from wastewater using EDTAD-functionalized MOF as highly efficient adsorbent
The recovery and subsequent reuse of heavy metal ions from industrial wastewater are crucial for promoting sustainable development, but they also present significant challenges. In this article, ethylenediamin...
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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High-precision Q modeling and Q migration technology and its applications in loess plateau regions
The propagation of seismic waves in viscous media, such as the loess plateau and shallow gas regions, alters their amplitude, frequency, and phase due to absorption attenuation, resulting in reductions in the ...
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Open AccessSearch for the decay of the Higgs boson to a pair of light pseudoscalar bosons in the final state with four bottom quarks in proton-proton collisions at \( \sqrt{\textrm{s}} \) = 13 TeV
A search is presented for the decay of the 125 GeV Higgs boson (H) to a pair of new light pseudoscalar bosons (a), followed by the prompt decay of each a boson to a bottom quark-antiquark pair,
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Open AccessPrognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy
The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...
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Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase
Fluoroacetate dehalogenases (FAcD), a homodimeric enzyme, catalyzes the conversion of fluoroacetic acid to glycolic acid (GoA). It has been proved that the enzyme has a half-of-the-site reactivity. Namely, its...
