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Article
The Largest Plastid Genome of Monocots: a Novel Genome Type Containing AT Residue Repeats in the Slipper Orchid Cypripedium japonicum
Plastid genome studies on Orchidaceae, one of the largest families of flowering plants, have been limited to the subfamily Epidendroideae. To increase understanding of the plastid genome evolution in Orchidace...
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Article
The complete chloroplast genome of colchicine plants (Colchicum autumnale L. and Gloriosa superba L.) and its application for identifying the genus
The complete chloroplast genome of two colchicine medicinal plants is reported for the first time. Deletion of ycf 15 gene occurred only in ...
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Article
Fabrication of poly(L-lactide) porous beads coated with hydroxyapatite using a simple fluidic device for tissue engineering
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Article
Fabrication of poly(d,l-lactide-co-glycolide) nanoparticles using a simple fluidic device with a tapered glass capillary and the effect of thermodynamic parameters
Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles were prepared by nanoprecipitation method using a simple fluidic device with pristine and tapered glass capillaries. An organic PLGA solution and an aqueous pol...
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Article
Extract of Litsea japonica ameliorates blood–retinal barrier breakdown in db/db mice
Loss of blood–retinal barrier (BRB) properties is an important feature in the pathology of diabetic retinopathy. Endothelium integrity is important for the normal vascular function. Litsea japonica (Thunb.) Jussi...
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Article
Open AccessInhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-κB activation in cultured astrocytes and microglial BV-2 cells
ent-Sauchinone is a polyphenolic compound found in plants belonging to the lignan family. ent-Sauchinone has been shown to modulate the expression of inflammatory factors through the nuclear factor-kappa B (NF-κ...
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Article
(E)-2,4-Bis(p-hydroxyphenyl)-2-butenal enhanced TRAIL-induced apoptosis in ovarian cancer cells through downregulation of NF-κB/STAT3 pathway
Ovarian cancer is a cancerous growth arising from the ovary and with poor prognosis that usually have resistant to all currently available treatments. Whether (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (butenal) synt...
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Article
Myriocin induces apoptotic lung cancer cell death via activation of DR4 pathway
It has been known that myriocin inhibits melanoma growth. However, the effects and action mechanisms of myriocin on lung cancer cell growth have not been reported. In this study, we examined whether myriocin i...
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Article
Complete Chloroplast Genome of Chionographis japonica (Willd.) Maxim. (Melanthiaceae): Comparative Genomics and Evaluation of Universal Primers for Liliales
The complete chloroplast genome of Chionographis japonica (Willd.) Maxim. (Melanthiaceae, Liliales) was mapped using polymerase chain reaction and the Sanger method. The circular double-stranded DNA was a typical...
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Article
Open AccessPolygonum cuspidatum inhibits pancreatic lipase activity and adipogenesis via attenuation of lipid accumulation
Obesity causes metabolic disease and is a serious health problem around the world. Polygonum cuspidatum (POCU1b) has been used clinically for the treatment of constipation, gallstones, hepatitis, and inflammation...
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Article
Open AccessDistinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis
A rapid and sensitive method to determine the characteristics of carcinogens is needed. In this study, we used a microarray-based genomics approach, with a short-term in vivo model, in combination with insights f...
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Article
The phylogenetic relationships of Asparagales in Korea based on five plastid DNA regions
We performed a phylogenetic analysis of 13 families of Asparagales sensu APG III, including 59 Korean taxa representing 10 families based on five plastid regions sequences (matK, rbcL, rpoC1, rps3, and atpF-H int...
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Article
Molecular identification of Schisandra chinensis and its allied species using multiplex PCR based on SNPs
Schisandra chinensis (Turcz.) Baill. is a climbing woody vine found over a wide geographical range in northeast Asia. Its red five-flavored fruits have been used as drugs and food. In China and K...
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Article
Molecular phylogeny of tribe Forsythieae (Oleaceae) based on nuclear ribosomal DNA internal transcribed spacers and plastid DNA trnL-F and matK gene sequences
The tribe Forsythieae comprises 2 genera (Forsythia and Abeliophyllum) and 14 species distributed mostly in the Far East. Although Forsythieae is considered monophyletic, with many symplesiomorphic characters, th...
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Article
Anthraquinones from the Roots of Knoxia valerianoides inhibit the formation of advanced glycation end products and rat lens aldose reductase in vitro
Eight known compounds, lucidin (1), lucidin-ω-methyl ether (2), rubiadin (3), damnacanthol (4), 1,3,6-trihydroxy-2-methoxymethylanthraquinone (5), 3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (6), 1,3,6-trihy...
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Article
Open AccessGenotoxicity Studies on Carrageenan: Short-term In Vitro Assays
Carrageenan is a naturally-occurring sulfated polygalactan which has been widely used in the dairy industry and a gelling agent in non-dairy products. In this study, four short-term in vitro genotoxicity assays w...
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Article
Molecular evidence for the hybridity ofIlex × wandoensis and the phylogenetic study of KoreanIlex based on ITS sequence data
In this study, internal transcribed spacer (ITS) regions within the nuclear ribosomal DNA of KoreanIlex were analyzed in order to investigate any molecular evidence thatI. × wandoensis could serve as a putative h...
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Article
Open AccessIn Vitro Studies on the Genotoxic Effects of Wood Smoke Flavors
Smoke flavors based on the thermal decomposition of wood have been applied to a variety of food products as an alternative for traditional smoking. Despite its increasing use, the available genotoxicity data o...
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Article
Characterization of resistance mechanism in transgenic Nicotiana benthamiana containing Turnip crinkle virus coat protein
Two transgenic lines, of Nicotiana benthamiana expressing Turnip crinkle virus (TCV)-coat protein (CP) gene with contrasting phenotype, the highest (#3) and the lowest (#18) CP expressers, were selected and chall...
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Article
Establishment of an In Vitro Test System to Evaluate the Down-Regulatory Activities of Natural Products on IL-4
Interleukin-4 (IL-4), a representative TH2 cytokine, plays a pathologic role in the onset of various allergic diseases including atopic dermatitis, atopic rhinitis, and asthma. Several drug candidates that down-r...
