49 Result(s)

Article

Lactoferrin in the Preterm Infants' Diet Attenuates Iron-Induced Oxidation Products

Free radical injury is thought to play a significant role in the pathogenesis of several disease processes in low birth weight premature infants including retinopathy of prematurity and necrotizing enterocolit...

Talkad S Raghuveer, Erin M McGuire, Sean M Martin, Brett A Wagner… in Pediatric Research (2002)

Article

Hematocrit Correlates Well with Circulating Red Blood Cell Volume in Very Low Birth Weight Infants

Although circulating red blood cell (RBC) volume is a better measure of total body oxygen delivering capacity than hematocrit (HCT), circulating RBC volume is more difficult to measure. Thus, the HCT is often ...

Donald M Mock, Edward F Bell, Gary L Lankford, John A Widness in Pediatric Research (2001)

Article

Antioxidant Status and Oxidant Stress in Very Low Birthweight Infants during the First Month of Life

James K Friel, Ekhard E Ziegler, John A Widness, Tianan Jiang… in Pediatric Research (1999)

Article

Multicenter Evaluation of a Novel Low Volume Blood Gas and Chemistry Monitor for Neonates

G Billman, G Dudell, John A Widness, L Adcock, D Hall, J Koska… in Pediatric Research (1999)

Article

Erythropoietin Receptor Gene Expression in Humans Is Greater in the Fetus Compared to the Adult

John A Widness, David J Lambert, Robert L Schmidt, Brian C Schutte in Pediatric Research (1999)

Article

Hematocrit Correlates Well with Red Cell Volume in Preterm Infants 784

Donald M Mock, Gary L Lankford, John A Widness, Edward F Bell in Pediatric Research (1998)

Article

The Life Span of Erythrocytes Transfused to Preterm Infants

This study was made to determine the life span of adult red cells transfused to early preterm infants. Nineteen very preterm infants (birth weight, 878.7 ± 221 g; gestational age, 26.8 ± 1.5 wk at birth) were ...

Harry Bard, John A Widness in Pediatric Research (1997)

Article

Erythrocyte Incorporation and Absorption of ⁵⁸Fe in Premature Infants Treated with Erythropoietin

We hypothesized that treatment of very low birth weight premature infants with r-HuEPO would increase erythrocyte incorporation and gastrointestinal absorption of iron. Infants with birth weights ≤1.25 kg and ...

John A Widness, Kenneth A Lombard, Ekhard E Ziegler, Robert E Serfass… in Pediatric Research (1997)

Article

CHANGING PATTERNS OF RED BLOOD CELL TRANSFUSION IN VERY LOW BIRTHWEIGHT INFANTS. † 1500

John A Widness, Victoria J Seward, Irma J Kromer, Leon F Burmeister… in Pediatric Research (1996)

Article

Circulatory and Metabolic Effects of Hypoxia in the Hyperinsulinemic Ovine Fetus

ABSTRACT: Fetuses of women whose diabetes is poorly controlled often exhibit hypoxemia and elevated catecholamine concentrations at birth. In the ovine fetus, experimental hyperinsulinemia results in hypoxemia...

Barbara S Stonestreet, John A Widness, Dennis J Berard in Pediatric Research (1995)

Article

The Proportions of ^Gγ- and ^Aγ-Globins in the Fetal Hemoglobin Synthesized in Preterm and Term Infants

ABSTRACT: The change in ^Gγ to ^Aγ ratio in relation to the switchover of fetal HB (HbF) to adult Hb (α₂β₂) synthesis has not been well defined. The γ-globins of HbF (α₂γ₂) have either glycine (^Gγ) or alanine (^Aγ) ...

Harry Bard, John A Widness, Ekhard E Ziegler, Carmen Gagnon… in Pediatric Research (1995)

Article

The Reactivation of Fetal Hemoglobin Synthesis during Anemia of Prematurity

ABSTRACT: Increased fetal Hb (HbF) synthesis has been shown to occur during fetal hypoxemia and severe anemia. To determine whether increased HbF synthesis occurs during anemia of prematurity, the levels of Hb...

Harry Bard, Christian Lachance, John A Widness, Carmen Gagnon in Pediatric Research (1994)

Article

143 SERUM IMMUNOREACTIVE ERYTHROPOIETIN (Ep) CORRELATES WITH HEMOGLOBIN (Hb) LEVEL AND RATE OF GROWTH DURING INFANCY

Ep is thought to be the major factor controlling erythropoiesis throughout development. Its production is stimulated by tissue hypoxemia. Because there are no data on the relationship of Ep and Hb in healthy t...

John A Widness, Pamela I Kling, Samuel J Fomon, Robert L Schmidt in Pediatric Research (1990)

Article

42 DEVELOPMENTAL CHANGES IN ERYTHROPOIETIN (Ep) PHARMACOKINETICS IN FETAL AND NEONATAL SHEEP

Ep is the primary hormone responsible for erythrocyte production throughout development. It has been proposed that recombinant human Ep (rhEp) be used for the treatment of anemia in premature human neonates. B...

John A Widness, Peier Veng-Pedersen, Nishit B Modi, Robert L Schmidt… in Pediatric Research (1990)

Article

The Effects of Acute Uterine Ischemia on Fetal Circulation¹

ABSTRACT: The effects of acute maternal hemorrhage on uterine blood flow and fetal circulation were investigated in pregnant sheep. Nine chronically instrumented pregnant sheep (114–128 d gestation), phlebotom...

Sandra A Calvert, John A Widness, Oh William, Barbara S Stonestreet in Pediatric Research (1990)

Article

The Effect of Prolonged Intrauterine Hyperinsulinemia on Iron Utilization in Fetal Sheep

ABSTRACT: Newborn infants of poorly controlled insulin-dependent diabetic mothers demonstrate a redistribution of iron from serum and tissue stores into red blood cells. These changes may be due to increases i...

Michael K Georgieff, John A Widness, Marla M Mills… in Pediatric Research (1989)

Article

Impermeability of the Ovine Placenta to ³⁵S-Recombinant Erythropoietin

ABSTRACT: Controversy exists regarding the placental permeability of erythropoietin (Ep), a glycoprotein hormone that regulates red blood cell production in the fetus, newborn, and adult after tissue hypoxia. ...

John A Widness, Thomas A Malone, R Allan Mufson in Pediatric Research (1989)

Article

84 IMMUNOREACTIVE ERYTHROPOIETIN AND ERYTHROPOIESIS STIMULATING FACTOR(S) IN PLASMA FROM HYPERTRANSFUSED NEONATAL AND ADULT MICE

The objective was to study whether the high erythropoietic stimulatory activity in plasma from neonatal mice is erythropoietin (Ep) alone or Ep in combination with other factors. Plasma from hypertransfused (h...

Truls Sanengen, Gisela K Clemons, Sverre Halvorsen, John A Widness in Pediatric Research (1988)