180 Result(s)

Article

Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial

This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in ...

Shun Lu, Hongming Pan, Lin Wu, Yu Yao… in Signal Transduction and Targeted Therapy (2023)

Article

Analysis of mRNA-miRNA interaction network reveals the role of CAFs-derived exosomes in the immune regulation of oral squamous cell carcinoma

Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcino...

Wei-Zhou Wang, Xue Cao, Li Bian, Yue Gao, Ming Yu, Yi-Ting Li, Jian-Guo Xu… in BMC Cancer (2023)

Article

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127⁺ and KLRG1⁺ CD8 T cells

The combination of PD-1 blockade with neoadjuvant chemotherapy (NAC) has achieved unprecedented clinical success in non-small cell lung cancer (NSCLC) compared to NAC alone, but the underlying mechanisms by wh...

Zhenzhen Hui, Yulin Ren, Dong Zhang, Yulong Chen, Wenwen Yu… in npj Precision Oncology (2023)

Article

Apatinib plus etoposide in pretreated patients with advanced triple-negative breast cancer: a phase II trial

Treatment options for pretreated triple-negative breast cancer (TNBC) are limited. This study aimed to evaluate the efficacy and safety of apatinib, an antiangiogenic agent, in combination of etoposide for pre...

Mengru Cao, Hailing Lu, Shi Yan, Hui Pang, Lichun Sun, Chunhong Li… in BMC Cancer (2023)

Article

Single-cell transcriptome analysis reveals stem cell-like subsets in the progression of Waldenström’s macroglobulinemia

Waldenström’s macroglobulinemia (WM) is an uncommon lymphoproliferative disorder, and the precise cellular landscape and the mechanisms of progression from IgM monoclonal gammopathy of undetermined significanc...

Yu Qiu, **ao-shuang Wang, Yuan Yao, Yan-min Si… in Experimental Hematology & Oncology (2023)

Article

Surufatinib plus toripalimab in patients with advanced solid tumors: a single-arm, open-label, phase 1 trial

This phase 1 trial evaluated the safety, preliminary efficacy, and pharmacokinetics of surufatinib, a small molecular tyrosine kinase inhibitor, combined with toripalimab, a programmed cell death protein-1 ant...

Yanshuo Cao, Ming Lu, Yu Sun, Jifang Gong… in Journal of Cancer Research and Clinical On… (2023)

Article

Tumor buster - where will the CAR-T cell therapy ‘missile’ go?

Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic mod...

Chunrun Qu, Hao Zhang, Hui Cao, Lanhua Tang, Haoyang Mo, Fangkun Liu… in Molecular Cancer (2022)

Article

Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal tract. Previous reports have revealed that primary...

Shan-Shan Li, **ao-Hui Zhai, Hai-Ling Liu… in Experimental Hematology & Oncology (2022)

Article

Correction: Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma

**n Zhu, Jia-jie Xu, Si-si Hu, Jian-guo Feng… in Journal of Experimental & Clinical Cancer … (2022)

Article

Reference genome assemblies reveal the origin and evolution of allohexaploid oat

Common oat (Avena sativa) is an important cereal crop serving as a valuable source of forage and human food. Although reference genomes of many important crops have been generated, such work in oat has lagged beh...

Yuanying Peng, Honghai Yan, Laichun Guo, Cao Deng, Chunlong Wang… in Nature Genetics (2022)

Article

Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2)

LCAR-B38M is a chimeric antigen receptor T cell product with two binding domains targeting B cell maturation antigen. Our previous reports showed a remarkable efficacy of LCAR-B38M in patients with relapsed/re...

Wan-Hong Zhao, Bai-Yan Wang, Li-Juan Chen, Wei-Jun Fu… in Journal of Hematology & Oncology (2022)

Article

Novel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia

Chimeric antigen receptor-engineered T (CAR-T) cells have shown promising efficacy in patients with relapsed/refractory B cell acute lymphoblastic leukemia (R/R B-ALL). However, challenges remain including lon...

Cheng Zhang, Jia** He, Li Liu, Jishi Wang, Sanbin Wang, Ligen Liu… in Blood Cancer Journal (2022)

Article

A promising Prognostic risk model for advanced renal cell carcinoma (RCC) with immune-related genes

Renal cell carcinoma (RCC) is a third most common tumor of the urinary system. Nowadays, Immunotherapy is a hot topic in the treatment of solid tumors, especially for those tumors with pre-activated immune state.

Peng Cao, Ji-Yue Wu, Jian-Dong Zhang, Ze-Jia Sun, **ang Zheng, Bao-Zhong Yu… in BMC Cancer (2022)

Article

Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis

Esophageal squamous cell carcinoma (ESCC) is a common invasive malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been reported to be involved in cancer ...

Song-tao Xue, Bin Zheng, Shi-qiang Cao, Jian-cheng Ding, Guo-sheng Hu… in Molecular Cancer (2022)

Article

tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner

tRNA-derived fragments (tRFs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of tRFs to colorectal cancer (CRC) remain largely unknown.

Ying Han, Yinghui Peng, Shanshan Liu… in Journal of Experimental & Clinical Cancer … (2022)

Article

On-treatment blood TMB as predictors for camrelizumab plus chemotherapy in advanced lung squamous cell carcinoma: biomarker analysis of a phase III trial

Camrelizumab plus chemotherapy significantly prolonged progression-free survival (PFS) and overall survival (OS) compared to chemotherapy alone as first-line treatment in advanced lung squamous cell carcinoma ...

Tao Jiang, Jianhua Chen, **ngxiang Xu, Ying Cheng, Gongyan Chen… in Molecular Cancer (2022)